Carbon Monoxide Generated by Heme Oxygenase-1 Activity Confers Tolerogenic Capacity to Dendritic Cells

The characterization and role of regulatory T cells in immune reactions

“…Tr1 cells can also be induced by co-culturing of T cells with TGFbeta/IL-10-expressing "tolerogenic" DCs (73,76,79) or immature DCs (63). Dendritic cells can influence Tr1 cell function in the IDOor HO-1-dependent pathway which seems to be functionally connected with IL-10 and has a role in regulating Tr1 cell activation (52,80,81). It is possible that IDO+ DCs can induce subsets of Tr1 Treg cells as well as suppress local T responses to antigens which are presented by neighboring IDO-negative DCs in the mechanism of "bystander" suppression (52).…”