Carbon monoxide intoxication: An updated review

Prockop, Leon D.; Chichkova, Rossitza I.

doi:10.1016/j.jns.2007.06.037

Cited by 640 publications

(429 citation statements)

References 51 publications

Supporting

Mentioning

371

Contrasting

Unclassified

Order By: Relevance

“…On an average, exposure of more than 100 ppm (i.e for every 999,900 molecules of air, 100 molecules of CO) is hazardous to the human health [11]. In a closed space like bathroom, concentration of CO can easily build up to the dangerous level.…”

Section: Discussionmentioning

confidence: 99%

Carbon Monoxide Poisoning due to Gas Water Heater

Bista

Manandhar

Mishra

et al. 2018

Janaki Med. Coll. J. Med. Sci.

View full text Add to dashboard Cite

Background and Objectives: Carbon Monoxide (CO) poisoning is a leading cause of injury and death due to poisoning in many parts of the world. Among numerous sources of CO, the gas water heater can be a potential under looked source causing an accidental Carbon monoxide poisoning. In the perspective of Kathmandu valley, where there are houses with small bathrooms, inadequate ventilation and absent CO detectors, gas water heaters can be extremely dangerous even if it liberates small amount of CO gas. Herein, we present a case of CO poisoning to increase awareness about the gas water heater use and the possible risk of CO poisoning in our community.Presentation of Case: A 34 years old healthy female from Patan, presented with the history of loss of consciousness for 15 minute while taking bath on a gas water heater. There was no spontaneous respiration, no cardiac activity and her body temperature was below normal.Discussion: CO is toxic to all aerobic forms to life. CO binds to hemoglobin 230 times faster than oxygen causing cellular hypoxic damage and death. CO poisoning is not uncommon in our society and many such cases are misdiagnosed for some other illness.Conclusion: Use of the gas water heaters and likelihood of CO poisoning should be notified as a public concern. People need to be aware of these hazards to prevent fatal events and likely death due to exploitation of gas water heaters. Janaki Medical College Journal of Medical Sciences (2017) Vol. 5(2): 56-59

show abstract

Section: Discussionmentioning

confidence: 99%

Carbon Monoxide Poisoning due to Gas Water Heater

Bista

Manandhar

Mishra

et al. 2018

Janaki Med. Coll. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…The liver metabolizes as much as onethird of inhaled methylene chloride to CO. A significant percentage of methylene chloride is stored in the tissues, and continued release results in elevated CO levels for at least twice as long as with direct CO inhalation. The half-time of CO in a healthy adult takes 4 hours breathing on air, 1.5 hours breathing on 100% oxygen, and 20 minutes in hyperbaric oxygen circumstances [2].…”

Section: Toxicokinetics Of Carbon Monoxidementioning

confidence: 99%

Carbon Monoxide Intoxication: Experiences from Hungary

Gara¹

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

View full text Add to dashboard Cite

Carbon monoxide (CO) is odorless, colorless, tasteless, and nonirritating gas. Hence, mild CO poisoning often remains unrecognized and appears lethally. Carbon and gas systems, unfavorable architectural designs and machines may also cause intoxications. The prevalence rates in Hungary ranged from 2.37 to 3.80 cases per 100,000 people per year between 2013 and 2015; fatality rates have been decreased from 5.96 in 2013 to 3.38 in 2015. Given the vagueness and the broad spectrum of complaints, misdiagnosis of CO toxicity is common. The gold standard diagnosis is detecting the level of circulating carboxyhemoglobin (CO-Hgb). The measurement of CO-Hgb can be performed via blood-gas analyses or by spectrophotometry. Treatment protocol should follow the ACBDE rule. Administration of 100% oxygen should be performed as soon as possible. Later in-hospital management includes evaluation, treatment and prevention of further peripheral organ damage and long-term neurological complications. Fetuses and children are prone to suffer more severe intoxication due to higher oxygen demand. Though hyperbaric oxygen is the mainstay therapy, a prompt cesarean section is effective in preventing further intoxication. In conclusion, fatal CO intoxication can occur due to plain early signs and symptoms. Hyperbaric oxygen therapy should be considered in severe intoxication, in fetal and children.

show abstract

“…Myelin damage is constant and ranges from discrete, perivascular foci in the corpus callosum, the internal-external capsule and the optic tracts usually seen in comatose patients who died within 1 week, to extensive periventricular demyelination and axonal destruction observed in comatose subjects with longer survival, sometimes leading to formation of plaques of demyelination [30]. A distinct constellation of brain and MRI abnormalities appears premortem and in those surviving an exposure.…”

Section: Neurologic Effectsmentioning

confidence: 99%

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Bird¹

2017

Toxicol Open Access

View full text Add to dashboard Cite

Carbon monoxide exposure remains a public health concern worldwide. Despite the burden that carbon monoxide exerts, significant controversy exists regarding optimal treatment of exposed persons. Particular controversy exists around neurologic effects of carbon monoxide exposure, how best to evaluate for neurocognitive dysfunction, and effects on the fetus of pregnant women. This review focuses on the mechanism of injury from carbon monoxide, and summarizes the data regarding neurocognitive dysfunction and fetal effects of exposure.

show abstract

Carbon monoxide intoxication: An updated review

Cited by 640 publications

References 51 publications

Carbon Monoxide Poisoning due to Gas Water Heater

Carbon Monoxide Poisoning due to Gas Water Heater

Carbon Monoxide Intoxication: Experiences from Hungary

Neurologic and Pregnancy Effects of Carbon Monoxide Exposure

Contact Info

Product

Resources

About