Carbon monoxide is not always a poison gas for human organism: Physiological and pharmacological features of CO

Olas, Beata

doi:10.1016/j.cbi.2014.08.005

Cited by 52 publications

(37 citation statements)

References 60 publications

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“…[10,11] In this study, we use a unified first-principles methodology for all environments (gas phase clusters, molecules adsorbed on a rare-gas surface or embedded into a rare-gas matrix) to derive these interaction potentials and afterwards the vibrational and structural effects caused by clustering and embedding. [13] Argon in the form of clusters or matrices, is an ideal solvent model as it interacts with CO mainly through van der Waals (vdW) forces, and the relatively limited size of the system allows us to use elaborate theoretical treatments. As a benchmark system for our approach, we study the carbon monoxide molecule interacting with argon clusters or embedded into a cold Ar matrix.…”

Section: Imentioning

confidence: 99%

Understanding of matrix embedding: a theoretical spectroscopic study of CO interacting with Ar clusters, surfaces and matrices

Mahjoubi

Benoit

Jaı̈dane

et al. 2015

Phys. Chem. Chem. Phys.

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Through benchmark studies, we explore the performance of PBE density functional theory, with and without Grimme's dispersion correction (DFT-D3), in predicting spectroscopic properties for molecules interacting with rare gas matrices. Here, a periodic-dispersion corrected model of matrix embedding is used for the first time. We use PBE-D3 to determine the equilibrium structures and harmonic vibrational frequencies of carbon monoxide in interaction with small Ar clusters (CO-Arn, n = 1, 2, 3), with an Ar surface and embedded in an Ar matrix. Our results show a converging trend for both the vibrational frequencies and binding energies when going from the gas-phase to a fully periodic approach describing CO embedding in Ar. This trend is explained in terms of solvation effects, as CO is expected to alter the structure of the Ar matrix. Due to a competition between CO-Ar interactions and Ar-Ar interactions, perturbations caused by the presence of CO are found to extend over several Å in the matrix. Accordingly, it is mandatory to fully relax rare gas matrices when studying their interaction with embedded molecules. Moreover, we show that the binding energy per Ar is almost constant (∼-130 cm(-1) atom(-1)) regardless of the environment of the CO molecule. Finally, we show that the concentration of the solute into the cold matrix influences the spectroscopic parameters of molecules embedded into cold matrices. We suggest hence that several cautions should be taken before comparing these parameters to gas phase measurements and to theoretical data of isolated species.

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Section: Imentioning

confidence: 99%

Understanding of matrix embedding: a theoretical spectroscopic study of CO interacting with Ar clusters, surfaces and matrices

Mahjoubi

Benoit

Jaı̈dane

et al. 2015

Phys. Chem. Chem. Phys.

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“…Furthermore, the highest activity of the non-inducible HO-2 was detected in the brain. CO produced via HO-2 functions as a signalling molecule in the central nervous system and in the circulatory system (reviewed in Olas, 2014).…”

Section: Introductionmentioning

confidence: 99%

Evidence for a role of heme oxygenase-1 in the control of cardiac function in zebrafish (Danio rerio) larvae exposed to hypoxia

Tzaneva

Perry

2016

Journal of Experimental Biology

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Carbon monoxide (CO) is a gaseous neurotransmitter produced from the breakdown of heme via heme oxygenase-1 (HO-1; hypoxiainducible isoform) and heme oxygenase-2 (HO-2; constitutively expressed isoform). In mammals, CO is involved in modulating cardiac function. The role of the HO-1/CO system in the control of heart function in fish, however, is unknown and investigating its physiological function in lower vertebrates will provide a better understanding of the evolution of this regulatory mechanism. We explored the role of the HO-1/CO system in larval zebrafish (Danio rerio) in vivo by investigating the impact of translational gene knockdown of HO-1 on cardiac function. Immunohistochemistry revealed the presence of HO-1 in the pacemaker cells of the heart at 4 days post-fertilization and thus the potential for CO production at these sites. Sham-treated zebrafish larvae (experiencing normal levels of HO-1) significantly increased heart rate ( f H ) when exposed to hypoxia (Pw O2 =30 mmHg). Zebrafish larvae lacking HO-1 expression after morpholino knockdown (morphants) exhibited significantly higher f H under normoxic (but not hypoxic) conditions when compared with sham-treaded fish. The increased f H in HO-1 morphants was rescued ( f H was restored to control levels) after treatment of larvae with a CO-releasing molecule (40 µmol l −1 CORM). The HO-1-deficient larvae developed significantly larger ventricles and when exposed to hypoxia they displayed higher cardiac output ( _ Q) and stroke volume (SV). These results suggest that under hypoxic conditions, HO-1 regulates _ Q and SV presumably via the production of CO. Overall, this study provides a better understanding of the role of the HO-1/CO system in controlling heart function in lower vertebrates. We demonstrate for the first time the ability for CO to be produced in presumptive pacemaker cells of the heart where it plays an inhibitory role in setting the resting cardiac frequency.

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“…151,155 HO-3 aktivitesi düşüktür ve hem bağlayan protein gibi işlev görmektedir. 154 Sistemik olarak üretilen CO'nun büyük bö-lümü akciğerlerde alveola-kapiller membrandan hızla difüze olarak ekspirasyonla atılmaktadır.…”

Section: Santral Si̇ni̇r Si̇stemi̇ Patoloji̇leri̇nde Hi̇drojen Sülfür İle İlunclassified

“…161 HO-1 enzim eksikliği olan bir grup hastada, erken gelişen aterosklerotik lezyonlar bulunmuştur, yani aterosklerotik süreci önleyici etkilerinin olabileceği düşünülmektedir. 155 Antiinflamatuar etkileri vardır. LPS bağımlı proinflamatuar sitokinlerin ekspresyonunu inhibe etmektedir.…”

Section: Santral Si̇ni̇r Si̇stemi̇ Patoloji̇leri̇nde Hi̇drojen Sülfür İle İlunclassified

Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide

Nomenoğlu¹,

Yılmaz²

2017

Turkiye Klinikleri J Neur

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Carbon monoxide is not always a poison gas for human organism: Physiological and pharmacological features of CO

Cited by 52 publications

References 60 publications

Understanding of matrix embedding: a theoretical spectroscopic study of CO interacting with Ar clusters, surfaces and matrices

Understanding of matrix embedding: a theoretical spectroscopic study of CO interacting with Ar clusters, surfaces and matrices

Evidence for a role of heme oxygenase-1 in the control of cardiac function in zebrafish (Danio rerio) larvae exposed to hypoxia

Gas Mediators in the Nervous System: Nitric Oxide, Hydrogen Sulfide and Carbon Monoxide

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