Carbon Monoxide Poisoning and Subsequent Cardiovascular Disease Risk

Lee, Feng-You; Chen, Wei-Kung; Lin, Cheng‐Li; Kao, Chia‐Hung

doi:10.1097/md.0000000000000624

Cited by 58 publications

(46 citation statements)

References 27 publications

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“…Arrhythmia was the most common cause of death after the acute phase, with paroxysmal tachycardia as the most frequent (24%), followed by ventricular fibrillation or flutter (15%) and paroxysmal supraventricular tachycardia (7%). (10) HBO is an effective therapy for CO poisoning. (1) However, during HBO, electronic devices, such as monitors, cannot be used because of the risk of fire.…”

Section: Discussionmentioning

confidence: 99%

Late-onset sick sinus syndrome after carbon monoxide poisoning

2018

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Carbon monoxide (CO) is a known, potent poisonous gas that causes hypoxaemia because of its high affinity for haemoglobin. It also induces inflammatory responses that cause tissue injury, particularly to the nervous and cardiovascular systems. Here we present a case of late-onset sick sinus syndrome (SSS) after CO poisoning. Arrhythmia during the acute phase has been recorded in the literature, but to the best of our knowledge, this is the first report of late-onset SSS. Late-onset neuropathy after CO poisoning is well known, and it seems that a similar mechanism develops in cardiac conduction after CO poisoning. This report highlights the importance of followup for arrhythmia after CO poisoning.

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Section: Discussionmentioning

confidence: 99%

Late-onset sick sinus syndrome after carbon monoxide poisoning

2018

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“…A population-based longitudinal cohort study was performed in Taiwan in 2015 to determine whether patients with CO poisoning are associated with higher risk of developing cardiovascular diseases [82] . They studied the incidence of arrhythmias, coronary artery diseases and congestive heart failure in CO-poisoned patients.…”

Section: Carbon Monoxidementioning

confidence: 99%

“…Results of their study showed that CO poisoning was significantly associated with a higher risk of arrhythmias with only a trend for an association between CO exposure and coronary artery disease and congestive heart failure. The incidence of all three cardiovascular diseases was higher in patients with coexisting comorbidity or high poisoning severity [82] .…”

Section: Carbon Monoxidementioning

confidence: 99%

Inhaled matters of the Heart

Zaky¹,

Ahmad

Dell’Italia

et al. 2015

Cardiovasc Regen Med

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Inhalations of atmospheric pollutants, especially particulate matters, are known to cause severe cardiac effects and to exacerbate preexisting heart disease. Heart failure is an important sequellae of gaseous inhalation such as that of carbon monoxide. Similarly, other gases such as sulphur dioxide are known to cause detrimental cardiovascular events. However, mechanisms of these cardiac toxicities are so far unknown. Increased susceptibility of the heart to oxidative stress may play a role. Low levels of antioxidants in the heart as compared to other organs and high levels of reactive oxygen species produced due to the high energetic demand and metabolic rate in cardiac muscle are important in rendering this susceptibility. Acute inhalation of high concentrations of halogen gases is often fatal. Severe respiratory injury and distress occurs upon inhalation of halogens gases, such as chlorine and bromine; however, studies on their cardiac effects are scant. We have demonstrated that inhalation of high concentrations of halogen gases cause significant cardiac injury, dysfunction, and failure that can be critical in causing mortalities following exposures. Our studies also demonstrated that cardiac dysfunction occurs as a result of a direct insult independent of coexisting hypoxia, since it is not fully reversed by oxygen supplementation. Therefore, studies on offsite organ effects of inhaled toxic gases can impact development of treatment strategies upon accidental or deliberate exposures to these agents. Here we summarize the knowledge of cardiovascular effects of common inhaled toxic gases with the intent to highlight the importance of consideration of cardiac symptoms while treating the victims.

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“…[6] Studies have shown correlation between levels of CO in air with mortality rates and hospital admissions for heart failure. [7,8] Thus, exposure to CO at varying levels in the workplace produces a range of different effects from headache and lethargy to coma, seizures, and death that can interfere with an individual's working capacity. [9] Diagnosis of CO toxicity is difficult because of vague presentation of diverse symptoms.…”

Section: Introductionmentioning

confidence: 99%

Analysis of breath carbon monoxide among urban automobile drivers

Chitra¹,

R²,

Meerasa³

2018

Natl J Physiol Pharm Pharmacol

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Background: Air pollution caused by automobiles can pose serious health hazard due to urbanization. Carbon monoxide (CO) is one of the six criteria for air pollution related to urbanization. Urban drivers are occupationally at risk of exposure to CO. Aims and Objectives: This study was undertaken to assess the levels of CO in breath among the exposed group of urban automobile drivers and to compare breath CO levels among various group of drivers based on their years of experience or duration of exposure. Materials and Methods: A cross-sectional analysis of breath sample for the presence of CO was conducted on automobile drivers (n = 101) using different type of motor vehicles in urban Chennai using breath CO analyzer (Vitalograph 29700). Mean CO levels were compared among groups using ANOVA. Proportion in groups was assessed by χ

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Carbon Monoxide Poisoning and Subsequent Cardiovascular Disease Risk

Abstract: Supplemental Digital Content is available in the text

Cited by 58 publications

References 27 publications

Late-onset sick sinus syndrome after carbon monoxide poisoning

Late-onset sick sinus syndrome after carbon monoxide poisoning

Inhaled matters of the Heart

Analysis of breath carbon monoxide among urban automobile drivers

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