Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide production

Keijzer, Christiaan; Pérez, Roberto; Lange, J. de

doi:10.1186/1471-2253-5-6

Cited by 21 publications

(14 citation statements)

References 33 publications

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“…Although important with desflurane, this production is insignificant with sevoflurane [15]. Environmental pollution is an essential preoccupation for anaesthesiologists using halogenated anaesthetics, and must be considered despite low sevoflurane toxicity.…”

Section: Physicochemical Propertiesmentioning

confidence: 99%

Sevoflurane inside and outside the operating room

Michel

Constantin

2009

Expert Opinion on Pharmacotherapy

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Background: Sevoflurane is often presented as a near-perfect anaesthetic. After 10 years in the operating room, new uses are emerging outside. Objective: To remind readers of the principal characteristics of sevoflurane, to affirm its usefulness for day-case anaesthesia and to consider the recent new uses. Methods: The discussion of the physical properties, pharmacokinetics, metabolism, mechanisms of action and clinical effects is based on classic, essential papers. Recent literature concerning emerging utilizations of sevoflurane was analysed. Results: Sevoflurane presents many benefits with minimum inconvenience. It allows rapid inhalation induction, maintenance and rapid recovery. It has little toxicity and its haemodynamic and respiratory depressive effects are moderate and well tolerated. It is already widely use for sedation for magnetic resonance imaging in children. Its use in paediatric or adult intensive care could improve the management of pain and sedation.

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Section: Physicochemical Propertiesmentioning

confidence: 99%

Sevoflurane inside and outside the operating room

Michel

Constantin

2009

Expert Opinion on Pharmacotherapy

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“…It has been reported that CO is produced by the interaction of volatile anesthetics, including sevoflurane (12,13). We eliminated the influence of CO production through this interaction in our study, as we used intravenous anesthesia.…”

Section: Discussionmentioning

confidence: 99%

Carboxyhemoglobin changes in relation to inspired oxygen fraction during general anesthesia

Gavrilovska-Brzanov¹,

Slaninka-Miceska²,

Кузмановска³

et al. 2017

Serb J Anes Inten Therap

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“…20 In the absence of adequate water, the carbanion decomposes and subsequently interacts with hydroxide or residual water, generating CO. 20 Sevoflurane and halothane can also generate CO, yet lack a difluoromethyl ether group, suggesting that other, less well defined mechanisms may be involved. 21 Importantly, CO production via degradation by conventional absorbents has been demonstrated with all of the volatile anesthetic agents currently in use today. 13,21,22 …”

Section: Co Exposure During General Endotracheal Anesthesiamentioning

confidence: 99%

Anesthesia-Related Carbon Monoxide Exposure: Toxicity and Potential Therapy

Levy

2016

Anesthesia &Amp; Analgesia

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Exposure to carbon monoxide (CO) during general anesthesia can result from volatile anesthetic degradation by carbon dioxide absorbents as well as re-breathing of endogenously produced CO. Although adherence to the Anesthesia Patient Safety Foundation guidelines reduces the risk of CO poisoning, patients may still experience a sub-toxic CO exposure during low-flow anesthesia. The consequences of such exposures are relatively unknown. In contrast to the widely recognized toxicity of high CO concentrations, the biological activity of low concentration CO has recently been shown be cytoprotective. As such, low dose CO is being explored as a novel treatment for a variety of different diseases. Here we review the concept of anesthesia-related CO exposure, identify the sources of production, detail the mechanisms of overt CO toxicity, highlight the cellular effects of low dose CO, and discuss the potential therapeutic role for CO as a part of routine anesthetic management.

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Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide production

Abstract: Background: Desflurane and enflurane have been reported to produce substantial amounts of carbon monoxide (CO) in desiccated sodalime. Isoflurane is said to produce less CO and sevoflurane and halothane should produce no CO at all.

Cited by 21 publications

References 33 publications

Sevoflurane inside and outside the operating room

Sevoflurane inside and outside the operating room

Carboxyhemoglobin changes in relation to inspired oxygen fraction during general anesthesia

Anesthesia-Related Carbon Monoxide Exposure: Toxicity and Potential Therapy

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