Carbon nanodot decorated acellular dermal matrix hydrogel augments chronic wound closure

Bankoti, Kamakshi; Rameshbabu, Arun Prabhu; Datta, Sayanti; Roy, Madhurima; Goswami, Piyali; Roy, Sribash; Das, Amit Kumar; Ghosh, Sudip Kumar; Dhara, Santanu

doi:10.1039/d0tb01574a

Cited by 36 publications

(27 citation statements)

References 42 publications

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“…They retain completely analogous biochemical signaling and physical cues with good biocompatibility and low immunogenicity, which are favorable to create regenerative microenvironment for wound healing. In addition, they can facilitate adhesion, survival, and differentiation of stem cells, as well as promoting host cell infiltration and revascularization ( Nie et al, 2015 ; Bankoti et al, 2020a ). Acellular matrices can be isolated from full skins ( Hsieh et al, 2020 ; Lin et al, 2020 ) and adipose tissues ( Dongen et al, 2019 ; Tan et al, 2019 ; Pu et al, 2020 ).…”

Section: Fabrication Of Hydrogel For Wound Healingmentioning

confidence: 99%

Biomimetic Hydrogels to Promote Wound Healing

Fan

Saha

Hanjaya‐Putra

2021

Front. Bioeng. Biotechnol.

115

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Wound healing is a common physiological process which consists of a sequence of molecular and cellular events that occur following the onset of a tissue lesion in order to reconstitute barrier between body and external environment. The inherent properties of hydrogels allow the damaged tissue to heal by supporting a hydrated environment which has long been explored in wound management to aid in autolytic debridement. However, chronic non-healing wounds require added therapeutic features that can be achieved by incorporation of biomolecules and supporting cells to promote faster and better healing outcomes. In recent decades, numerous hydrogels have been developed and modified to match the time scale for distinct stages of wound healing. This review will discuss the effects of various types of hydrogels on wound pathophysiology, as well as the ideal characteristics of hydrogels for wound healing, crosslinking mechanism, fabrication techniques and design considerations of hydrogel engineering. Finally, several challenges related to adopting hydrogels to promote wound healing and future perspectives are discussed.

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Section: Fabrication Of Hydrogel For Wound Healingmentioning

confidence: 99%

Biomimetic Hydrogels to Promote Wound Healing

Fan

Saha

Hanjaya‐Putra

2021

Front. Bioeng. Biotechnol.

115

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“…The four compartments (epidermis, dermis, hypodermis, and blood vessels) were successfully matured under polycaprolactone (PCL)-based printed platform, indicating that extracellular matrix of skin can promote skin regeneration and wound healing. As the ECM hydrogels derived form porcine skin possesses good plasticity, injectability, biocompatibility and renewability, it can be applied to irregular skin tissue injuries and accelerate tissue healing [ [26] , [27] , [28] , [29] ]. Moreover, ECM is closely related to thrombosis [ 30 ]; under certain physiological conditions, the exposure of subcutaneous ECM and the subsequent platelet accumulation influence the control of hemorrhage [ [31] , [32] , [33] ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, ECM hydrogels is a relative new point to be applied in hemostasis application. These characteristics show that ECM hydrogels can control active bleeding by promoting thrombosis and can be utilized for irregular wounds to effectively control hemorrhage and accelerate healing [ [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] ]. Despite these advantages, ECM hydrogels still lack antimicrobial functionality.…”

Section: Introductionmentioning

confidence: 99%

Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds

Cai

Chen

et al. 2021

Materials Today Bio

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Prevention of bacterial infection and reduction of hemorrhage, the primary challenges posed by trauma before hospitalization, are essential steps in prolonging the patient's life until they have been transported to a trauma center. Extracellular matrix (ECM) hydrogel is a promising biocompatible material for accelerating wound closure. However, due to the lack of antibacterial properties, this hydrogel is difficult to be applied to acute contaminated wounds. This study formulates an injectable dermal extracellular matrix hydrogel (porcine acellular dermal matrix (ADM)) as a scaffold for skin defect repair. The hydrogel combines vancomycin, an antimicrobial agent for inducing hemostasis, expediting antimicrobial activity, and promoting tissue repair. The hydrogel possesses a porous structure beneficial for the adsorption of vancomycin. The antimicrobial agent can be timely released from the hydrogel within an hour, which is less than the time taken by bacteria to infest an injury, with a cumulative release rate of approximately 80%, and thus enables a relatively fast bactericidal effect. The cytotoxicity investigation demonstrates the biocompatibility of the ADM hydrogel. Dynamic coagulation experiments reveal accelerated blood coagulation by the hydrogel. In vivo antibacterial and hemostatic experiments on a rat model indicate the healing of infected tissue and effective control of hemorrhaging by the hydrogel. Therefore, the vancomycin-loaded ADM hydrogel will be a viable biomaterial for controlling hemorrhage and preventing bacterial infections in trauma patients.

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“…Excessive ROS can induce oxidative stress, which can result in a series of unfavorable effects including deferred cellular behaviors, extended inflammation period, reduced re-epithelization, and diminished angiogenesis. Thus, excessive oxidative stress is detrimental to normal wound healing [105,121,122].…”

Section: Loading With Antioxidant Agentsmentioning

confidence: 99%

“…Antioxidant agents, such as ferulic acid, alpha-lipoic acid, and Keap1 siRNA, are capable of eliminating free radicals and have been successfully loaded in different nanoparticulate delivery systems to treat skin wounds [104,105,119]. For example, to strengthen the antioxidant ability of ADM scaffolds, Pesaraklou et al have immersed the ADM scaffolds in a cerium oxide nanoparticle (CeO 2 NP) solution to produce a CeO 2 NP-ADM scaffold (Table 2) [104].…”

Section: Loading With Antioxidant Agentsmentioning

confidence: 99%

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

Huang

Xie

et al. 2021

Pharmaceutics

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Membranous extracellular matrix (ECM)-based scaffolds are one of the most promising biomaterials for skin wound healing, some of which, such as acellular dermal matrix, small intestinal submucosa, and amniotic membrane, have been clinically applied to treat chronic wounds with acceptable outcomes. Nevertheless, the wide clinical applications are always hindered by the poor mechanical properties, the uncontrollable degradation, and other factors after implantation. To highlight the feasible strategies to overcome the limitations, in this review, we first outline the current clinical use of traditional membranous ECM scaffolds for skin wound healing and briefly introduce the possible repair mechanisms; then, we discuss their potential limitations and further summarize recent advances in the scaffold modification and fabrication technologies that have been applied to engineer new ECM-based membranes. With the development of scaffold modification approaches, nanotechnology and material manufacturing techniques, various types of advanced ECM-based membranes have been reported in the literature. Importantly, they possess much better properties for skin wound healing, and would become promising candidates for future clinical translation.

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Carbon nanodot decorated acellular dermal matrix hydrogel augments chronic wound closure

Abstract: Impaired skin regeneration in chronic wounds like diabetes corresponds to high oxidative stress, poor angiogenesis and insufficient collagen hyperplasia. Therefore, a multifaceted strategy for treatment is required to address critical...

Cited by 36 publications

References 42 publications

Biomimetic Hydrogels to Promote Wound Healing

Biomimetic Hydrogels to Promote Wound Healing

Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds

Membranous Extracellular Matrix-Based Scaffolds for Skin Wound Healing

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