Carbon nanomaterials-based electrochemical aptasensors

Wang, Zonghua; Yu, Jie‐Hui; Gui, Rijun; Jin, Hui; Xia, Yanzhi

doi:10.1016/j.bios.2015.11.093

Cited by 152 publications

(67 citation statements)

References 90 publications

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“…In addition, CNT-based chemical and biological sensors have generated considerable recent research interest, as well. This is not only due to the increase of the sensor detection efficiency when CNTs are present, but also to the numerous ways in which they can be functionalized, thus enormously widening the range of potential bio-chemical applications [18,19]. Furthermore, not only the electrochemical reactivity of several fundamental biomolecules is exceptionally increased by CNTs, but also the electron-transfer reaction of proteins [20,21].…”

Section: What Are Cnts and Why Are They Relevant For Sensingmentioning

confidence: 99%

“…Recently, Wang et al investigated the use of CNTs, and other carbon-based materials, for the fabrication of electrochemical aptasensors, i.e., sensors whose transduction is performed by aptamers [18]. Their study clearly pointed out the advantages of using CNTs for this type of sensing, which relies both on the excellent adsorption of biomolecules on the functionalized nanotubes surface and the acceleration of the electronic conversion.…”

Section: What Are Cnts and Why Are They Relevant For Sensingmentioning

confidence: 99%

“…Focusing specifically on CNTs, their poor solubility in an aqueous medium strongly impedes their use in almost all biological mediums [3,18,20]. It is precisely to overcome this issue that the surface functionalization of CNTs has attracted widespread interest in the last few years.…”

Section: What Are Cnts and Why Are They Relevant For Sensingmentioning

confidence: 99%

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Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

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Section: What Are Cnts and Why Are They Relevant For Sensingmentioning

confidence: 99%

Section: What Are Cnts and Why Are They Relevant For Sensingmentioning

confidence: 99%

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Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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“…However, from another point of view, gold is a noble metal, and thus it is more expensive than most available materials. One alternative to overcome this drawback is found in research involving new electrode materials, such as carbon‐based electrodes, magnetic materials, and nanoparticles . Another trend focuses on the development of microelectrodes in miniaturized systems, which can reduce the manufacturing cost.…”

Section: Aptamer‐based Electrochemical Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

et al. 2017

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The use of biosensors in point‐of‐care (POC) testing devices has attracted considerable attention in the past few years, mainly because of their high specificity, portability, and relatively low cost. Coupling these devices with miniaturized electrochemical transducers has shown great potential toward simple, rapid, and cost‐effective analysis that can be performed in the field, especially for healthcare, environmental monitoring, and food quality control. For this reason, the number of publications in this field has grown exponentially over the past decade, making it a trending topic in current research. Although great improvement has been achieved in the field of electrochemical biosensing, there are still some challenges to overcome, especially concerning the improvement of sensing materials and miniaturization. In this Review, we summarize some of the most recent advances achieved in POC electrochemical biosensor applications, focusing on new materials and modifiers for biorecognition developed to improve sensitivity, specificity, stability, and response time.

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“…Most advances in electrochemical aptasensors involving nanomaterials revolve around applications in the biomedical field, due to enormous interest and the market share of commercial kits and sensors in this domain. The role of nanomaterials range from providing a support for increased aptamer loading with minimized steric hindrances to facilitating simple immobilisation and new sensing strategies, connecting the aptamers to electrodes via conducting nanomaterials (e. g. carbon nanotubes) and providing a higher electroactive area . While various new materials are actively investigated, gold nanoparticles (AuNPs), carbon nanotubes and graphene remain the preferred nanomaterials in electrochemical biosensors.…”

Section: Introductionmentioning

confidence: 99%

Advantages of Carbon Nanomaterials in Electrochemical Aptasensors for Food Analysis

et al. 2017

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Electrochemical aptasensors appear as promising tools in food analysis, able to provide sensitive, fast and cost-effective analysis, with the added advantage of portability. Carbon nanomaterials and in particular carbon nanotubes and graphene are among the nanomaterials most often used to build electrochemical aptasensors due to their good electrical conductivity, large surface area and multiple functionalisation possibilities. This review aims to give an overview of the types of carbon nanomaterials and their composites which have been used to enhance the performance of electrochemical aptasensors. Examples are detailed for the biosensors which were tested with real food samples. In these aptasensors, carbon nanomaterials have played different roles, from facilitating the immobilization of high amounts of aptamer and enhancing the electroactive area of the sensors to roles as nanocarrier for signaling probes in amplification schemes or even as electroactive probes generating the output signal. The survey of recent literature shows a positive evolution towards increased aptasensor testing with food samples. However, many challenges remain related to the better characterization of nanomaterials used, clarifying the roles of specific components in multi-component nanocomposites and widening the types of food matrices and analytes tested with the aptasensors. Although we are still far from knowing when these novel tools will replace classic analytical methods in food analysis, carbon nanomaterials will certainly continue to play an important role in the design of future electrochemical aptasensors for food analysis.

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Carbon nanomaterials-based electrochemical aptasensors

Cited by 152 publications

References 90 publications

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Electrochemical Biosensors in Point‐of‐Care Devices: Recent Advances and Future Trends

Advantages of Carbon Nanomaterials in Electrochemical Aptasensors for Food Analysis

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