Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

Hong, Guosong; Diao, Shuo; Antaris, Alexander L.; Dai, Hongjie

doi:10.1021/acs.chemrev.5b00008

Cited by 1,246 publications

(1,040 citation statements)

References 780 publications

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“…Numerous studies have documented the promise of carbon nanotubes as biological imaging agents. [36] Inspired by some of these works, we initially investigated the use of surfactant Pluronic F108 to solubilize the unfunctionalized nanohoops in aqueous media for biological studies-a strategy that has been successful for CNTs. [37] Although the solubility of the nanohoop increased in the presence of surfactant, cell imaging experiments were plagued by low signal response and aggregation (See Supplementary Information Figure 7 and Figure 8).…”

Section: Introductionmentioning

confidence: 99%

“…Related studies for other graphitic nanomaterials are often plagued by the inherent heterogeneity of those materials, again highlighting the advantage of the bottom-up synthetic approach for the nanohoops. [36] Finally, using epifluorescence microscopy, we next aimed to determine whether 1 is cell permeable and whether the fluorescence of the nanohoop is sufficient to generate bright images in live cells. HeLa cells were treated with a 10 µM solution of 1 in FBS free DMEM with 0.5% DMSO and the nuclear stain NucRedÒ 647 for 1 hour (Figure 3c, E-H).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells

White¹,

Yu²,

Kawashima³

et al. 2018

Preprint

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Abstract:The design and optimization of fluorescent molecules has driven the ability to interrogate complex biological events in real time. Notably, most advances in bioimaging fluorophores are based on optimization of core structures that have been known for over a century. Recently, new synthetic methods have resulted in an explosion of non-planar conjugated macrocyclic molecules with unique optical properties yet to be harnessed in a biological context. Herein we report the synthesis of the first aqueous-soluble carbon nanohoop (i.e. a macrocyclic slice of a carbon nanotube prepared via organic synthesis) and demonstrate its bioimaging capabilities in live cells. This work establishes the nanohoops as an exciting new class of macrocyclic fluorophores poised for further development as novel bioimaging tools.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells

White¹,

Yu²,

Kawashima³

et al. 2018

Preprint

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“…In the case of DNA, decoupling of DNA excitation frequency (UV) from the sensor and pump frequencies (NIR and visible) enables spectroscopic studies of DNA ionization under a range of experimental conditions. For example, one could employ the method for studying autoionization in self-assembled DNA-SWNT complexes, stable at ambient conditions in water solution and capable of penetrating live cells [12]. Our calculations indicate that DNA-to-SWNT AI is a dominant process that makes SWNTs ideal reporters in which the problems of previous sensor systems, for example, due to intra- DNA and DNA-to-solvent charge transport, have been minimized.…”

Section: Discussionmentioning

confidence: 92%

“…In this work, we explore the AI of single-stranded DNA (ssDNA) wrapped around single-wall carbon nanotubes (SWNT) which constitute an elementary nanomaterial with a great promise for such biotechnology applications as nanotherapeutics, nanopharmacology [12,13], and optical imaging. SWNTs are inexpensive and robust in synthesis, chemically inert, mechanically stable, and biocompatible [14,15].…”

Section: Swnt Ssdnamentioning

confidence: 99%

Two-color spectroscopy of UV excited ssDNA complex with a single-wall nanotube photoluminescence probe: Fast relaxation by nucleobase autoionization mechanism

et al. 2016

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SWNT ssDNADNA is capable to recover after absorbing ultraviolet (UV) radiation, for example, by autoionization (AI). Singlewall carbon nanotube (SWNT) two-color photoluminescence spectroscopy was combined with quantum mechanical calculations to explain the AI in self-assembled complexes of DNA wrapped around SWNT. DNA autoionization is a fundamental process wherein UV-photoexcited nucleobases dissipate energy by charge transfer to the environment without undergoing chemical damage. Here, single-wall carbon nanotubes (SWNT) are explored as a photoluminescent reporter for studying the mechanism and rates of DNA autoionization. Two-color photoluminescence spectroscopy allows separate photoexcitation of the DNA and the SWNTs in the UV and visible range, respectively. A strong SWNT photoluminescence quenching is observed when the UV pump is resonant with the DNA absorption, consistent with charge transfer from the excited states of the DNA to the SWNT. Semiempirical calculations of the DNA-SWNT electronic structure, combined with a Green's function theory for charge transfer, show a 20 fs autoionization rate, dominated by the hole transfer. Rate-equation analysis of the spectroscopy data confirms that the quenching rate is limited by the thermalization of the free charge carriers transferred to the nanotube reservoir. The developed approach has a great potential for monitoring DNA excitation, autoionization, and chemical damage both in vivo and in vitro arXiv:1512.00710v1 [cond-mat.mes-hall] 2 Dec 2015 2

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“…[4][5][6][7][8][9][10][11][12][13][14] Various bioactive molecules, such as anticancer drugs and small interfering RNAs, can be bound to the surface of SWNTs and thereby delivered to, and even inside, target cells. A major motivation for the latter would be the ability of SWNTs to absorb near-infrared (NIR) light efficiently.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Action of Single-Walled Carbon Nanotubes

Murakami

2017

Chem. Pharm. Bull.

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Photodynamic therapy is achieved by the combination of photosensitizers, harmless visible or nearinfrared (NIR) light, and molecular oxygen (O 2 ). Photosensitizers transfer their absorbed light energy to O 2 to generate a major active species in photodynamic therapy, singlet oxygen. In this review, I will discuss the possibility of single-walled carbon nanotubes as NIR photosensitizers, while explaining the general photophysics and photochemistry underlying photodynamic therapy as well as summarizing recent advances in the purification technologies for single-walled carbon nanotubes to reduce their toxicity concerns.

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Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

Cited by 1,246 publications

References 780 publications

Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells

Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells

Two-color spectroscopy of UV excited ssDNA complex with a single-wall nanotube photoluminescence probe: Fast relaxation by nucleobase autoionization mechanism

Photodynamic Action of Single-Walled Carbon Nanotubes

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