Carbon nanomaterials: Types, synthesis strategies and their application as drug delivery system for cancer therapy

Brindhadevi, Kathirvel; Garalleh, Hakim Al; Alalawi, Amr; Al-Sarayreh, Ebtisam

doi:10.1016/j.bej.2023.108828

Cited by 29 publications

(12 citation statements)

References 149 publications

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“…In contrast, GO is highly biocompatible and can be easily functionalized with targeting ligands. [99] Nanophotonics has witnessed recent progress that has resulted in the development of biosensing systems based on nanomaterials, which can detect diseasespecific biomarkers such as lncRNA. [100] A nanophotonic approach has been devised to efficiently and precisely capture lncRNAs via oligonucleotide-conjugated graphene quantumdot-nanoconjugates.…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

“…CNTs, which are cylinders composed of graphene sheets that have been coiled up, are amenable to lncRNA‐targeting compounds and are readily internalized by cancer cells. In contrast, GO is highly biocompatible and can be easily functionalized with targeting ligands [99] . Nanophotonics has witnessed recent progress that has resulted in the development of biosensing systems based on nanomaterials, which can detect disease‐specific biomarkers such as lncRNA [100] .…”

Section: Targeting Lncrnas For Therapeutic Applications; Nanocarriers...mentioning

confidence: 99%

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Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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This review article spotlights the burgeoning potential of using nanotherapeutic strategies to target long non‐coding RNAs (lncRNAs) in cancer cells. This updated discourse underlines the prominent role of lncRNAs in instigating cancer, facilitating its progression, and metastasis, validating lncRNAs' potential for being effective diagnostic biomarkers and therapeutic targets. The manuscript offers an in‐depth examination of different strategies presently employed to modulate lncRNA expression and function for therapeutic purposes. Among these strategies, Antisense Oligonucleotides (ASOs), RNA interference (RNAi) technologies, and the innovative CRISPR‐based gene editing tools garner noteworthy mention. A significant section of the review is dedicated to nanocarriers and their crucial role in drug delivery. These nanocarriers' efficiency in targeting lncRNAs in varied types of cancers is elaborated upon, validating the importance of targeted therapy. The manuscript culminates by reaffirming the promising prospects of targeting lncRNAs to enhance the accuracy of cancer diagnosis and improve treatment efficacy. Consequently, new paths are opened to more research and innovation in employing nanotherapeutic approaches against lncRNAs in cancer cells. Thus, this comprehensive manuscript serves as a valuable resource that underscores the vital role of lncRNAs and the various nano‐strategies for targeting them in cancer treatment.

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Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

Section: Targeting Lncrnas For Therapeutic Applications; Nanocarriers...mentioning

confidence: 99%

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Davodabadi,

Farasati Far,

Sargazi

et al. 2024

ChemMedChem

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“…One such strategy is the incorporation of chemotherapeutic drugs into DDSs. DDSs offer several advantages over classical chemotherapy treatment [115,116,139,140]:…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

et al. 2023

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With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

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“…Over the past two decades, many new drug delivery systems have been developed to enhance the aqueous solubility of drugs, increase their circulation time in the bloodstream, and thereby increase their therapeutic efficacy [1,2]. Various drug delivery systems have been developed with different designs, including polymeric micelles, metal nanoparticles, dendrimers, liposomes, and carbon nanotubes [3][4][5][6][7]. Among different nanocarriers used for controlled drug delivery, polymeric micelles (e.g., amphiphilic block copolymer micelles, unimolecular micelles, and cross-linked micelles) with tunable properties have shown great potential due to their excellent characteristics that brought them to the front line in the development of drug delivery systems [8,9].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Core Branching Density on Drug Release from Arborescent Poly(γ-benzyl L-glutamate) End-Grafted with Poly(ethylene oxide)

Alsehli,

Gauthier

2023

IJTM

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Amphiphilic dendritic copolymers of arborescent poly(γ-benzyl L-glutamate) (PBG) of generations G1 and G2, grafted at their chain ends with poly(ethylene oxide) (PEO) segments (PBG-eg-PEO) were synthesized, characterized, and evaluated as nanocarriers for doxorubicin (DOX). The copolymers were designed with hydrophobic PBG cores having three different branching densities and were characterized by proton nuclear magnetic resonance (1H NMR) spectroscopy, size exclusion chromatography (SEC), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Dynamic light scattering (DLS) measurements revealed that these amphiphilic molecules behaved like unimolecular micelles without significant aggregation in aqueous media such as phosphate-buffered saline (PBS), with diameters in the 13–29 nm range depending on the generation number and the core structure. Efficient encapsulation of DOX by these unimolecular micelles was demonstrated with drug loading capacities of up to 11.2 wt%, drug loading efficiencies of up to 67%, and pH-responsive sustained drug release, as determined by UV spectroscopy. The generation number of the copolymers and the branching density of the dendritic PBG core were found to have influenced the encapsulation and release properties of the micelles. Given the tailorable characteristics, good water dispersibility, and biocompatibility of the components used to synthesize the amphiphilic arborescent copolymers, these systems should be useful as robust nanocarriers for a broad range of therapeutic and diagnostic agents.

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Carbon nanomaterials: Types, synthesis strategies and their application as drug delivery system for cancer therapy

Cited by 29 publications

References 149 publications

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Nanomaterials‐Based Targeting of Long Non‐Coding RNAs in Cancer: A Cutting‐Edge Review of Current Trends

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Influence of the Core Branching Density on Drug Release from Arborescent Poly(γ-benzyl L-glutamate) End-Grafted with Poly(ethylene oxide)

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