Carbon Nanotube-Based Scaffolds for Cardiac Tissue Engineering—Systematic Review and Narrative Synthesis

Scott, Louie; Jurewicz, Izabela; Jeevaratnam, Kamalan; Lewis, Rebecca

doi:10.3390/bioengineering8060080

Cited by 18 publications

(5 citation statements)

References 112 publications

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“…The field of cardiovascular tissue engineering has made significant contributions to the management of heart diseases. It has played a crucial role in the development of transplant materials and the creation of biological models for preclinical pharmacological testing [46]. Additionally, it has proven to be essential in the structural repair of tissues with limited self-regeneration capabilities, such as tendons, ligaments, cartilage, and meniscus.…”

Section: Scaffolds In Fabric Engineeringmentioning

confidence: 99%

Recent Biotechnological Applications of Polyhydroxyalkanoates (PHA) in the Biomedical Sector—A Review

Diniz,

Mourão,

Xavier

et al. 2023

Polymers

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Petroleum-derived plastics are materials of great importance for the contemporary lifestyle, and are widely used commercially because they are low cost, resistant, malleable, and weightless, in addition to their hydrophobic character. However, some factors that confer the qualities of these materials also cause problems, mainly environmental, associated with their use. The COVID-19 pandemic aggravated these impacts due to the high demand for personal protective equipment and the packaging sector. In this scenario, bioplastics are environmentally positive alternatives to these plastics due to their applicability in several areas ranging from packaging, to biomedicine, to agriculture. Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers usually produced by microorganisms as an energy reserve. Their structural variability provides a wide range of applications, making them a viable option to replace polluting materials. PHAs can be applied in various biotechnology sectors, such as producing drug carriers and scaffolds for tissue engineering. This review aimed to survey works published in the last five years on the study and biotechnological application of PHAs in the biomedical sector, exploring the versatility and advantages of their use and helping to understand how to enhance their application.

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Section: Scaffolds In Fabric Engineeringmentioning

confidence: 99%

Recent Biotechnological Applications of Polyhydroxyalkanoates (PHA) in the Biomedical Sector—A Review

Diniz,

Mourão,

Xavier

et al. 2023

Polymers

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“…116 Carbon nanofibers (CNFs) and carbon nanotubes (CNTs) are cylindrical nanostructures made of graphene layers wrapped in plates (CNF) or hollow cylinders (CNT). 117 Graphene is a plate of carbon atoms to the thickness of an atom. 118 These structures exhibit unique physicochemical characteristics such as high electrical and thermal conductivity along with remarkable mechanical strength.…”

Section: Carbon-based Nanomaterials Scaffolds For Ctementioning

confidence: 99%

“…Carbon nanofibers (CNFs) and carbon nanotubes (CNTs) are cylindrical nanostructures made of graphene layers wrapped in plates (CNF) or hollow cylinders (CNT) 117 . Graphene is a plate of carbon atoms to the thickness of an atom 118 .…”

Section: Conductive Scaffoldsmentioning

confidence: 99%

Biodegradable functional macromolecules as promising scaffolds for cardiac tissue engineering

Saghebasl

Akbarzadeh

Gorabi

et al. 2022

Polymers for Advanced Techs

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Cardiovascular diseases, the major international health problem and the leading cause of death worldwide have been increasing in recent years due to population aging and lifestyle changes. Loss of cardiac muscle function after myocardial damage is one of the most critical challenges in cardiovascular medicine that has not yet been overcome. Tissue engineering (TE) has emerged as a promising therapeutic approach in modern medicine, targeting the substitution of damaged tissue with functional tissue grown inside an artificial scaffold. Great efforts have been made toward the construction of tissue engineering scaffolds that paved the way for extracellular matrix (ECM)-like biomaterial. In cardiac tissue engineering, key parameters must be determined to select the ideal biomaterial, such as biocompatibility, conductivity, mechanical features, degradation and swelling rate, surface properties, and cell viability, growth and proliferation. Among different scaffolding materials, a wide range of natural biological macromolecules and synthetic macromolecules have been utilized to produce scaffolds with multifunctionality for cardiac tissue engineering (CTE). In this review, we have focused on recent achievements in the field of synthetic biodegradable macromolecules (such as aliphatic polyesters, polyurethane, poly (glycerol sebacate)) and the significant strategies to construct electrically conductive scaffolds to regenerate the function of native cardiac tissue. These biodegradable macromolecules have several attractive properties, including biocompatibility, elasticity, good mechanical properties, compatibility with native cardiac tissue, and proper surface biochemistry to increase cardiac cell adhesion, making them appropriate candidates for CTE. Recently, a growing trend in the use of conductive scaffolds for cardiac regeneration has been witnessed. Different materials ranging from metals, ceramics, and polymers have been used as parts of conductive scaffolds for CTE, possessing conductivity assortments from a range of semiconductive to conductive. Moreover, this review paper also focuses on the main strategies to create electroconductive scaffolds for in vitro cardiac muscle regeneration.

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“…Neural, cardiac, muscle, and bone tissue engineering are four areas of research where CNT-based scaffolds have emerged as promising tools. In relation to neurites, cardiomyocytes, and myocytes, electrical conductivity in a scaffold promotes action potentials and intracellular communication ( Dong et al, 2020 ; Kunisaki et al, 2021 ; Scott et al, 2021 ). Concerning osteocytes, CNT promotes protein adsorption and improves scaffold rigidity to match the native bone environment better ( Patel et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

Shar,

Joung

2023

Front. Bioeng. Biotechnol.

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Carbon nanotube (CNT) nanocomposite scaffolds have emerged as highly promising frameworks for tissue engineering research. By leveraging their intrinsic electrical conductivity and valuable mechanical properties, CNTs are commonly dispersed into polymers to create robust, electrically conductive scaffolds that facilitate tissue regeneration and remodeling. This article explores the latest progress and challenges related to CNT dispersion, functionalization, and scaffold printing techniques, including electrospinning and 3D printing. Notably, these CNT scaffolds have demonstrated remarkable positive effects across various cell culture systems, stimulating neuronal growth, promoting cardiomyocyte maturation, and facilitating osteocyte differentiation. These encouraging results have sparked significant interest within the regenerative medicine field, including neural, cardiac, muscle, and bone regenerations. However, addressing the concern of CNT cytotoxicity in these scaffolds remains critical. Consequently, substantial efforts are focused on exploring strategies to minimize cytotoxicity associated with CNT-based scaffolds. Moreover, researchers have also explored the intriguing possibility of utilizing the natural cytotoxic properties of CNTs to selectively target cancer cells, opening up promising avenues for cancer therapy. More research should be conducted on cutting-edge applications of CNT-based scaffolds through phototherapy and electrothermal ablation. Unlike drug delivery systems, these novel methodologies can combine 3D additive manufacturing with the innate physical properties of CNT in response to electromagnetic stimuli to efficiently target localized tumors. Taken together, the unique properties of CNT-based nanocomposite scaffolds position them as promising candidates for revolutionary breakthroughs in both regenerative medicine and cancer treatment. Continued research and innovation in this area hold significant promise for improving healthcare outcomes.

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Carbon Nanotube-Based Scaffolds for Cardiac Tissue Engineering—Systematic Review and Narrative Synthesis

Cited by 18 publications

References 112 publications

Recent Biotechnological Applications of Polyhydroxyalkanoates (PHA) in the Biomedical Sector—A Review

Recent Biotechnological Applications of Polyhydroxyalkanoates (PHA) in the Biomedical Sector—A Review

Biodegradable functional macromolecules as promising scaffolds for cardiac tissue engineering

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

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