CARBON NANOTUBE-<i>GRAFT</i>-POLY(CITRIC ACID) NANOCOMPOSITES

Adeli, Mohsen; Bahari, Ali; Hekmatara, Hoda

doi:10.1142/s1793292008000824

Cited by 52 publications

(37 citation statements)

References 2 publications

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“…MWNT-g-PCA was synthesized according to procedures reported in the literature. 26,27 Briefly, 1 g of MWNTs was mixed with 20 mL of concentrated HNO 3 and H 2 SO 4 (1:3 ratio), and the mixture was sonicated for 30 minutes and refluxed for 24 hours at 100°C. The resulting black mixture was then diluted with 1 L of distilled water, filtered, and washed with deionized water to adjust the pH to 6.…”

Section: Functionalization Of Mwnts With Poly Citric Acidmentioning

confidence: 99%

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Sobhani¹,

Dinarvand²,

Atyabi³

et al. 2011

IJN

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Potential applications of carbon nanotubes have attracted many researchers in the field of drug delivery systems. In this study, multiwalled carbon nanotubes (MWNTs) were first functionalized using hyperbranched poly citric acid (PCA) to improve their hydrophilicity and functionality. Then, paclitaxel (PTX), a potent anticancer agent, was conjugated to the carboxyl functional groups of poly citric acid via a cleavable ester bond to obtain a MWNT- g -PCA-PTX conjugate. Drug content of the conjugate was about 38% (w/w). The particle size of MWNT- g -PCA and MWNT- g -PCA-PTX was approximately 125 and 200 nm, respectively. Atomic force microscopy and transmission electron microscopy images showed a curved shape for MWNT- g -PCA and MWNT- g -PCA-PTX, which was in contrast with the straight or linear conformation expected from carbon nanotubes. It seems that the high hydrophilicity of poly citric acid and high hydrophobicity of MWNTs led to conformational changes from a linear state to a curved state. Paclitaxel can be released from the MWNT- g -PCA-PTX conjugates faster at pH 6.8 and 5.0 than at pH 7.4, which was suitable for the release of the drug in tumor tissues and tumor cells. In vitro cytotoxicity studies were evaluated in the A549 and SKOV3 cell lines. MWNT- g -PCA had an insignificant cytotoxic effect on both cell lines. MWNT- g -PCA-PTX had more of a cytotoxic effect than the free drug over a shorter incubation time (eg, 24 hours versus 48 hours), which suggests improved cell penetration of MWNT- g -PCA-PTX. Therefore, paclitaxel conjugated to MWNT- g -PCA is promising for cancer therapeutics.

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Section: Functionalization Of Mwnts With Poly Citric Acidmentioning

confidence: 99%

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Sobhani¹,

Dinarvand²,

Atyabi³

et al. 2011

IJN

Self Cite

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“…Several water-soluble polymers have been covalently and non-covalently attached onto the surface of CNTs to produce modified water-soluble CNT-polymer (Table 1). Depending on the type of conjugated polymer, modified CNTs can be soluble in aqueous or organic solvents, for example, conjugation of polylactide or polycaprolactone onto the surface of CNTs tends to solubilization of CNTs in organic solvents such as chloroform [102,103]. It has been proved that polymers not only raise the functionality, biocompatibility and water solubility of CNT but also are able to change the CNTs conformations dramatically [102][103][104].…”

Section: Functionalization Of Cntsmentioning

confidence: 99%

“…Depending on the type of conjugated polymer, modified CNTs can be soluble in aqueous or organic solvents, for example, conjugation of polylactide or polycaprolactone onto the surface of CNTs tends to solubilization of CNTs in organic solvents such as chloroform [102,103]. It has been proved that polymers not only raise the functionality, biocompatibility and water solubility of CNT but also are able to change the CNTs conformations dramatically [102][103][104]. According to CNTs' polymeric and cationic innate abilities, soluble functionalized carbon nanotubes seem to represent an innovative drug delivery system, since they are capable to penetrate into the cell without altering their morphology [105,106].…”

Section: Functionalization Of Cntsmentioning

confidence: 99%

Modification of Carbon Nanotubes as an Effective Solution for Cancer Therapy

Tavakolifard¹,

Biazar²

2016

Nano BioMed ENG

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Carbon nanotubes (CNT) as a new class of nano-materials hold great potential for various biomedical applications. Owing to their unusual properties, carbon nanotubes have been extensively employed in electronics, nanotechnology and optics, among others. In spite of the great potential of carbon nanotubes in various domains of biomedicine, ineffcient dispersion in aqueous solutions and biological activities in vivo are still disputable. One important and feasible route in a struggle to overcome these obstacles is modification of CNTs with organic compounds and polymers, which have been widely studied and play a crucial role in biological and biomedical fields, particularly in the cancer therapy. This review focuses on the breakthrough of the recently used methods to functionalize onto the surface of carbon nanotubes with multiple chemical species in order to produce anticancer drug delivery systems for biomedical applications.

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“…CA has been mainly used as an acidifier, flavoring, and for microbial fermentations for a long time. Besides, CA has been employed as chelating agent for removing heavy metals in soils due to its carboxylic groups [10][11][12]. NPs with high surface to volume ratio and numerous -OH functional groups on their surfaces have a great tendency to aggregate.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of novel poly(vinyl chloride) nanocomposite films with zinc oxide immobilized with biocompatible citric acid

Mallakpour

Javadpour

2015

Colloid Polym Sci

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Herein, first ZnO nanoparticles (NPs) were modified with citric acid (CA) to prevent agglomeration and achieve good dispersion of NPs in poly(vinyl chloride) (PVC) matrix along with controlling the size. Different concentrations of modified ZnO-CA NPs were used to fabricate PVC/ZnO-CA nanocomposite films, and the obtained materials were characterized by several techniques such as Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, and transmission electron microscopy. Mechanical test and thermal analysis were also carried out on PVC/ZnO-CA nanocomposite films. The ultrasonic irradiation-which is an environmentally safe procedure-was applied for all cases.

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CARBON NANOTUBE-GRAFT-POLY(CITRIC ACID) NANOCOMPOSITES

Cited by 52 publications

References 2 publications

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Increased paclitaxel cytotoxicity against cancer cell lines using a novel functionalized carbon nanotube

Modification of Carbon Nanotubes as an Effective Solution for Cancer Therapy

Design and characterization of novel poly(vinyl chloride) nanocomposite films with zinc oxide immobilized with biocompatible citric acid

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