Carbon nanotubes among diesel exhaust particles: real samples or contaminants?

Jung, Heejung; Miller, Art; Park, Kihong; Kittelson, David B.

doi:10.1080/10962247.2013.812048

Cited by 39 publications

(16 citation statements)

References 30 publications

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“…3,4 For example, both fullerenes and carbon nanotubes are becoming good performances in the field of drug delivery. 8 Since human lung is easily accessible for CNPs, the increasing exposure of CNPs is putting human lungs at high risk. 6,7 Besides industrial production, most CNPs originate from incomplete combustion of fossil fuels and are thus abundant in the environment.…”

Section: Introductionmentioning

confidence: 99%

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Yue

et al. 2016

Phys. Chem. Chem. Phys.

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Increasing evidence indicates that carbon nanoparticles (CNPs), which mainly originate from incomplete combustion of fossil fuels, have an adverse impact on the respiratory system. Recent in vivo experiments have shown that the pulmonary toxicity of CNPs is attributed to their aggregation in pulmonary surfactant monolayers (PSMs) while the underlying mechanism of aggregation remains unclear. Here, by performing coarse grained molecular dynamics simulations, we demonstrate for the first time that the aggregation of carbon nanospheres (CNSs) in PSMs is in fact size-dependent and mediated by lipid extractions. Upon CNS deposition, neighbouring lipid molecules are extracted from PSMs to cover CNSs from the top side. The extracted lipids induce clustering of CNSs to maximize the CNS-lipid interaction, by forming inverse micelles to wrap the aggregated CNSs cooperatively. The formed CNS clusters perturb the molecule structure of the PSM and thus affect its biofunction on respiration. Our simulations show that during the expiration process, CNSs form clusters that perturb the mechanical properties of the PSM in a manner depending on the CNS size. With deep inspiration, a high concentration of large CNSs may induce PSM rupture and thus have a potential impact on its biophysical properties.

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Section: Introductionmentioning

confidence: 99%

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Yue

et al. 2016

Phys. Chem. Chem. Phys.

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“…commercialization of the ESPnano, this nanoparticle sampler has become an important tool for industrial hygienists and air quality researchers. This technology fills a unique gap in air quality monitoring, and its worldwide use is evidenced by many citations of the original work as well as published references to its application for the characterization of hazardous airborne particulate matter [Barone et al 2012;Jung et al 2013] and in occupational exposure studies [Miller et al 2010b;Bugarski et al 2016]. This device will be an important component in future work aimed at methods for characterizing and assessing nanoaerosols and other airborne hazards in the workplace.…”

Section: For More Informationmentioning

confidence: 99%

Technology News 562 - ESPnano characterizes hazardous airborne particles in the workplace.

2020

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“…In the study, BALF was obtained from bronchoscopies of asthmatic children, and CNT-like structures were observed inside lung cells. This was intriguing since CNTs can be generated from high-temperature diesel exhaust engines in a laboratory setting [78]. However, no direct evidence was given in the study with asthmatic children that defined the source of the CNT-like structures in inflammatory cells and therefore this study lacked a definitive link between exposure and disease outcome.…”

Section: Human Evidence For Enm-induced Asthmamentioning

confidence: 99%

The Toxicology of Engineered Nanomaterials in Asthma

Ihrie

Bonner

2018

Curr Envir Health Rpt

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Recent studies highlight the ability of metal nanoparticles (NPs) and carbon nanotubes (CNTs) to not only exacerbate pre-existing asthma in animal models but also initiate allergic airway disease directly. CNTs alone are shown to cause airway mucus production, elevated serum IgE levels, and increased T2 cytokine levels, all key indicators of asthma. The ability of ENMs to modulate the immune response in asthma varies depending on their physicochemical properties and exposure timing. CNTs consistently exacerbate asthma, as do Ni and TiO NPs, whereas some NPs like Au attenuate asthma. Evidence is strong that ENMs can contribute to allergic airway disease; however, more work is required to determine their mechanisms, and more epidemiological studies are needed to validate results from animal models.

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Carbon nanotubes among diesel exhaust particles: real samples or contaminants?

Cited by 39 publications

References 30 publications

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Technology News 562 - ESPnano characterizes hazardous airborne particles in the workplace.

The Toxicology of Engineered Nanomaterials in Asthma

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