Carbon Nanotubes for Biomedical Applications

doi:10.1007/978-3-642-14802-6

Cited by 31 publications

(2 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the early 1990s, the range of possible applications of CNTs has greatly expanded, and in recent years more and more efforts are being devoted to explore the use of CNTs for biomedical purposes [1][2][3][4]. The use of CNTs as intracellular transporters [5][6][7][8][9][10][11][12] is of special interest, as both the surface and their inner cavity facilitate loading with therapeutic and/or imaging agents (for a review of the comprehensive work done in this field the reader may refer to [13][14][15][16][17]).…”

Section: Introductionmentioning

confidence: 99%

Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique

Lamprecht

Gierlinger

Heister

et al. 2012

J. Phys.: Condens. Matter

View full text Add to dashboard Cite

The uptake of carbon nanotubes (CNTs) by mammalian cells and their distribution within cells is being widely studied in recent years due to their increasing use for biomedical purposes. The two main imaging techniques used are confocal fluorescence microscopy and transmission electron microscopy (TEM). The former, however, requires labeling of the CNTs with fluorescent dyes, while the latter is a work-intensive technique that is unsuitable for in situ bio-imaging. Raman spectroscopy, on the other hand, presents a direct, straightforward and label-free alternative. Confocal Raman microscopy can be used to image the CNTs inside cells, exploiting the strong Raman signal connected to different vibrational modes of the nanotubes. In addition, cellular components, such as the endoplasmic reticulum and the nucleus, can be mapped. We first validate our method by showing that only when using the CNTs' G band for intracellular mapping accurate results can be obtained, as mapping of the radial breathing mode (RBM) only shows a small fraction of CNTs. We then take a closer look at the exact localization of the nanotubes inside cells after folate receptor-mediated endocytosis and show that, after 8-10 h incubation, the majority of CNTs are localized around the nucleus. In summary, Raman imaging has enormous potential for imaging CNTs inside cells, which is yet to be fully realized.

show abstract

Section: Introductionmentioning

confidence: 99%

Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique

Lamprecht

Gierlinger

Heister

et al. 2012

J. Phys.: Condens. Matter

View full text Add to dashboard Cite

show abstract

“…They are electrically and thermally very conductive and chemically highly reactive. To employ CNTs in large quantities, there are a few limitations, such as the inability to synthesis CNTs with a predictable architecture [61], [62]. Hydrophobic CNTs have a non-uniform dispersion in biological settings; synthesis method of the CNT surface can overcome this constraint.…”

Section: Applications Of Carbon Nanotubes In Biomedicinementioning

confidence: 99%

Carbon nanomaterials advancements for biomedical applications

2023

View full text Add to dashboard Cite

The development of new technologies has helped tremendously in delivering timely, appropriate, acceptable, and reasonably priced medical treatment. Because of developments in nanoscience, a new class of nanostructures has emerged. Nanomaterials, because of their small size, display exceptional physio-chemical capabilities such as enhanced absorption and reactivity, increased surface area, molar extinction coefficients, tunable characteristics, quantum effects, and magnetic and optical properties. Researchers are interested in carbon-based nanomaterials due to their unique chemical and physical properties, which vary in thermodynamic, biomechanical, electrical, optical, and structural aspects. Due to their inherent properties, carbon nanomaterials, including fullerenes, graphene, carbon nanotubes (CNTs), and carbon nanofibers (CNFs), have been intensively studied for biomedical applications. This article is a review of the most recent findings about the development of carbon-based nanomaterials for use in biosensing, drug delivery, and cancer therapy, among other things.

show abstract

Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

et al. 2017

View full text Add to dashboard Cite

Surface and interfacial chemistry is of fundamental importance in functional nanomaterials applied in catalysis, energy storage and conversion, medicine, and other nanotechnologies. It has been a perpetual challenge for the scientific community to get an accurate and comprehensive picture of the structures, dynamics, and interactions at interfaces. Here, some recent examples in the major disciplines of nanomaterials are selected (e.g., nanoporous materials, battery materials, nanocrystals and quantum dots, supramolecular assemblies, drug-delivery systems, ionomers, and graphite oxides) and it is shown how interfacial chemistry can be addressed through the perspective of solid-state NMR characterization techniques.

show abstract

Carbon Nanotubes for Biomedical Applications

Cited by 31 publications

References 60 publications

Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique

Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique

Carbon nanomaterials advancements for biomedical applications

Understanding Surface and Interfacial Chemistry in Functional Nanomaterials via Solid‐State NMR

Contact Info

Product

Resources

About