Carbon Nanotubes for Delivery of Quercetin as Anticancer Drug: Theoretical Study

Daneshmehr, Shahla

doi:10.1016/j.mspro.2015.11.128

Cited by 16 publications

(5 citation statements)

References 25 publications

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“…The study showed pH-dependent drug release potential and anti-cancer activity of CNTs loaded with curcumin. Apart from curcumin, there is a range of studies demonstrating that anticancer herbal compounds can be effectively combined with CNTs: paclitaxel [80,81], docetaxel [82], vinca alkaloids [83], camptothecin [84,85], podophyllotoxin [86], quercetin [87], oridonin [88], etc.…”

Section: Carbon Nanotubes In Cancer Treatmentmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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Section: Carbon Nanotubes In Cancer Treatmentmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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“…However, no biological assays were performed. In 2015, a theoretical study was published on the feasibility of using SWCNTs for the delivery of quercetin, a plant flavonoid [ 49 ], and in 2022, SW- and MWCNTs were examined in vitro as nanocarriers for the delivery of 7-hydroxy flavone (7-HF), which belongs to the flavone subgroup of flavonoids and is a potent anti-inflammatory agent. In the latter study, the authors measured the cytotoxicity of pristine SW- and MWCNTs and -COOH-functionalized SWCNTs against several normal and cancer cell lines, but not CNTs functionalized with 7-HF [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidized-Multiwalled Carbon Nanotubes as Non-Toxic Nanocarriers for Hydroxytyrosol Delivery in Cells

et al. 2023

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Carbon nanotubes (CNTs) possess excellent physicochemical and structural properties alongside their nano dimensions, constituting a medical platform for the delivery of different therapeutic molecules and drug systems. Hydroxytyrosol (HT) is a molecule with potent antioxidant properties that, however, is rapidly metabolized in the organism. HT immobilized on functionalized CNTs could improve its oral absorption and protect it against rapid degradation and elimination. This study investigated the effects of cellular oxidized multiwall carbon nanotubes (oxMWCNTs) as biocompatible carriers of HT. The oxidation of MWCNTs via H2SO4 and HNO3 has a double effect since it leads to increased hydrophilicity, while the introduced oxygen functionalities can contribute to the delivery of the drug. The in vitro effects of HT, oxMWCNTS, and oxMWCNTS functionalized with HT (oxMWCNTS_HT) were studied against two different cell lines (NIH/3T3 and Tg/Tg). We evaluated the toxicity (MTT and clonogenic assay), cell cycle arrest, and reactive oxygen species (ROS) formation. Both cell lines coped with oxMWCNTs even at high doses. oxMWCNTS_HT acted as pro-oxidants in Tg/Tg cells and as antioxidants in NIH/3T3 cells. These findings suggest that oxMWCNTs could evolve into a promising nanocarrier suitable for targeted drug delivery in the future.

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“…Existen estudios acerca de la síntesis de nanopartículas unidas a QUE (Baksi et al, 2018) (Curcio et al, 2012). Daneshmehr (2015) ha calculado de forma teórica DFT (density functional theory) de la interacción de NTC de pared simple con quercetina, obteniendo un buen nanoportador. De igual manera, se han realizado estudios experimentales del nanocompuesto Q-PMAA-NTC (quercetina-ácido metrácrilico, nanotubos de carbono de pared múltiple), en donde encontraron que la formación de este nanocompuesto incrementa la estabilidad de la QUE, y ser utilizado en terapia de cáncer (Cirillo et al, 2013).…”

Section: Modelado De Nanovectores Para El Tratamiento Del Cáncerunclassified

Modelado de nanovectores para el tratamiento del cáncer

Cruz-Luis,

Hernández Huerta,

Romero Díaz

et al. 2023

ICBI

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La conjugación de nanoestructuras con moléculas bioactivas se emplea en el diagnósticos y tratamiento del cáncer. La quercetina (QUE) es un flavonoide con efecto antioxidante que inhibe el estrés oxidativo y la viabilidad de células cancerosas. Phaseolus lunatus (PHA) es una lectina con afinidad a estructuras de N-acetil-D-galactosamina (GalNAc) por lo cual aglutina eritrocitos del grupo sanguíneo A. El objetivo de este trabajo fue modelar la interacción entre QUE, PHA con nanotubos de carbono de pared múltiple carboxilados (NTCPM-co) mediante docking y dinámica molecular, utilizando HEX6.3 y AMBER22. Se identificaron seis sitios de interacción entre QUE y PHA (F12-V114-N129-D217-D218-W219), mientras que los NTCPM-co no interfieren con los sitios de reconocimiento a GalNAc de la lectina. En conclusión, la implementación de nanovectores acoplados a QUE y PHA podría mejorar el efecto citotóxico sobre células cancerígenas.

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Carbon Nanotubes for Delivery of Quercetin as Anticancer Drug: Theoretical Study

Cited by 16 publications

References 25 publications

The Advances in Biomedical Applications of Carbon Nanotubes

The Advances in Biomedical Applications of Carbon Nanotubes

Oxidized-Multiwalled Carbon Nanotubes as Non-Toxic Nanocarriers for Hydroxytyrosol Delivery in Cells

Modelado de nanovectores para el tratamiento del cáncer

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