Carbon nanotubes for in vivo cancer nanotechnology

Zhang, Shuai; Yang, Kai; Liu, Zhuang

doi:10.1007/s11426-010-4115-8

Cited by 20 publications

(6 citation statements)

References 65 publications

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“…As stated above, rapid functionalization using fluorescein derivatives was used to secure the traceability of the constructs in cells. This protocol was chosen because proximal hydroxyl functions in the b-D-glucan can be functionalized by derivatization with boronic acids, [74][75][76] which form boronic esters with 1,2-or 1,3-diols. [77][78][79][80][81] In addition, boronic acids derivatized with biotin have been shown in our earlier works to retain their saccharide-binding potential upon streptavidin conjugation to microspheres 78 and gold surfaces.…”

Section: Cellular Behavior Of the Fluorescent Supramolecular Carbon Nmentioning

confidence: 99%

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Riss

Mirabello

et al. 2017

Chem

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Pascu and colleagues have designed a general, non-covalent directed selfassembly procedure to obtain radioactive and/or luminescent biocompatible carbon-based nanohybrids. They were able to fill carbon-nanocapsule-based tubular structures with the radionuclide of choice in water. Nanoproducts were investigated by UV-vis, fluorescence, Raman, NMR, and EDX spectroscopy; SEM, TEM, AFM, and confocal and two-photon fluorescence microscopy; and cytotoxicity assays. Furthermore, in vivo microPET imaging in Wistar rats showed localization in the lung and kidney.

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Section: Cellular Behavior Of the Fluorescent Supramolecular Carbon Nmentioning

confidence: 99%

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

Riss

Mirabello

et al. 2017

Chem

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“…As with liposomes and dendrimers, a biocompatible coating such as PEGlyation can remarkably reduce in vivo toxicity of CNTs. 36 …”

Section: Currently Available Drug Delivery Systemsmentioning

confidence: 99%

“…34 However, the insolubility of CNTs can pose health complications. [33][34][35][36] For example, CNTs without functionalisation can accumulate in the lungs, which leads to pulmonary toxicity and inflammation. 35 This perniciousness is highly dependent on material preparation and administration route of CNTs.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Silica-based mesoporous nanoparticles for controlled drug delivery

et al. 2013

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Drug molecules with lack of specificity and solubility lead patients to take high doses of the drug to achieve sufficient therapeutic effects. This is a leading cause of adverse drug reactions, particularly for drugs with narrow therapeutic window or cytotoxic chemotherapeutics. To address these problems, there are various functional biocompatible drug carriers available in the market, which can deliver therapeutic agents to the target site in a controlled manner. Among the carriers developed thus far, mesoporous materials emerged as a promising candidate that can deliver a variety of drug molecules in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles are widely used as a delivery reagent because silica possesses favourable chemical properties, thermal stability and biocompatibility. Currently, sol-gel-derived mesoporous silica nanoparticles in soft conditions are of main interest due to simplicity in production and modification and the capacity to maintain function of bioactive agents. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release. The properties of mesopores, including pore size and porosity as well as the surface properties, can be altered depending on additives used to fabricate mesoporous silica nanoparticles. Active surface enables functionalisation to modify surface properties and link therapeutic molecules. The tuneable mesopore structure and modifiable surface of mesoporous silica nanoparticle allow incorporation of various classes of drug molecules and controlled delivery to the target sites. This review aims to present the state of knowledge of currently available drug delivery system and identify properties of an ideal drug carrier for specific application, focusing on mesoporous silica nanoparticles.

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“…[44][45][46][47] Most inorganic nanomaterials were known to usually suffer from their defects of poor biodegradability and heavy metal leakage, and therefore this hinders their comprehensive application. [48][49][50][51] In contrast, organic phototherapy reagents were found to show prominent biodegradability and low toxicity in phototherapy. [52][53][54][55][56][57][58] Many papers about organic phototherapy reagents have reported to enhance nonradiative decay pathways.…”

Section: Introductionmentioning

confidence: 99%