Carbon nanotubes in drug delivery: focus on infectious diseases

Rosen, Yitzhak; Elman, Noel M.

doi:10.1517/17425240902865579

Cited by 61 publications

(24 citation statements)

References 107 publications

(266 reference statements)

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“…Carbon nanotubes (CNTs) are new carbon materials and have found many applications in a wide areas such as adsorption, separation, catalysis, sensors, biomedicine and electronic devices [9][10][11][12][13][14]. Due to their large specific surface area, small pore size, hollow and layered structures, carbon nanotubes have been proven to possess a great potential as superior adsorbents for removing many kinds of organic and inorganic contaminants from aqueous solution [15].…”

Section: Introductionmentioning

confidence: 99%

Synergistic and competitive adsorption of organic dyes on multiwalled carbon nanotubes

Wang

et al. 2012

Chemical Engineering Journal

213

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h i g h l i g h t s" Adsorption of methylene blue and acid red 183 on a MWCNT in single and binary dye systems was investigated. " MWCNT shows higher adsorption capacity to methylene blue in both systems. " A synergistic effect for basic and acid dyes occurs in a binary dye system. t r a c tA multiwalled carbon nanotube (MWCNT) was used as an adsorbent for removal of a cationic dye (methylene blue, MB) and acid dye (acid red 183, AR183) from aqueous solution in single and binary dye systems. Characterization of the MWCNT and MWCNT-dye systems were performed using several techniques such as Fourier transform infrared spectroscopy (FTIR), thermogravimetric-differential thermal analysis (TG-DTA), zeta potential and elemental analysis. Adsorption tests showed that the MWCNT presented higher adsorption of MB than AR183 in single and binary dye systems, revealing that p-p stacking is the main driving force responsible for the dye-MWCNT interaction. In single dye systems, the MWCNT presented the maximum adsorption capacities of MB and AR183 at 59.7 and 45.2 mg/g, respectively. In a binary dye system, a synergistic effect due to electronic attraction between MB and AR183 was found at low AR183 concentration (10 mg/L), which promotes the adsorption of both dyes on the MWCNT. However, MB adsorption could be reduced at higher AR183 concentration (>20 mg/L) due to a strong electrostatic attraction between MWCNT-AR183.

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Section: Introductionmentioning

confidence: 99%

Synergistic and competitive adsorption of organic dyes on multiwalled carbon nanotubes

Wang

et al. 2012

Chemical Engineering Journal

213

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“…Nanotubes in combination with nerve growth factors help in enabling specific cells to differentiate into neurons and thus treat neurological disorders. [82]…”

Section: Nanotubes In Brain Targetingmentioning

confidence: 99%

Advancement in carbon nanotubes: basics, biomedical applications and toxicity

Beg

Rizwan

Sheikh

et al. 2011

Journal of Pharmacy and Pharmacology

277

145

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Objectives Carbon nanotubes (CNTs) have attracted much attention by researchers worldwide in recent years for their small dimensions and unique architecture, and for having immense potential in nanomedicine as biocompatible and supportive substrates, as a novel tool for the delivery of therapeutic molecules including peptides, RNA and DNA, and also as sensors, actuators and composites. Key findings CNTs have been employed in the development of molecular electronic, composite materials and others due to their unique atomic structure, high surface area-tovolume ratio and excellent electronic, mechanical and thermal properties. Recently they have been exploited as novel nanocarriers in drug delivery systems and biomedical applications. Their larger inner volume as compared with the dimensions of the tube and easy immobilization of their outer surface with biocompatible materials make CNTs a superior nanomaterial for drug delivery. Literature reveals that CNTs are versatile carriers for controlled and targeted drug delivery, especially for cancer cells, because of their cell membrane penetrability. Summary This review enlightens the biomedical application of CNTs with special emphasis on utilization in controlled and targeted drug delivery, as a diagnostics tool and other possible uses in therapeutic systems. The review also focuses on the toxicity aspects of CNTs, and revealed that genotoxic potential, mutagenic and carcinogenic effects of different types of CNTs must be explored and overcome by formulating safe biomaterial for drug delivery. The review also describes the regulatory aspects and clinical and market status of CNTs.

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“…Modification of the SWCNT can generate sites for the attachment of bioactive molecules. Carbon nanotubes have the potential to address the challenges of combating infectious agents by both minimizing toxicity by dose reduction of standard therapeutics and allowing a multiple payload capacity to achieve both targeted activity and combating infectious strains, resistant strains, in particular [41]. One of their unique characteristics is the network of carbon atoms in the nanometer scale, allowing the creation of nanochannels via cellular membranes.…”

Section: Carbon Nanotube-based Antimicrobial Therapeuticsmentioning

confidence: 99%

Advances in use of functionalized carbon nanotubes for drug design and discovery

Jain¹

2012

Expert Opinion on Drug Discovery

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Carbon nanotubes combine more properties relevant to drug development and delivery than any other nanomaterial. Although a tremendous amount of basic research has been done on CNTs during the past decade, little of this is nearing translation into human applications. No CNT-based medicine has reached clinical trials. Nevertheless, CNT conjugation with other molecules has extended the horizons for their potential therapeutic applications. The most promising of these is PEGylation, which extends the survival of CNTs in circulation. Potential future applications of CNTs include combination of diagnostics and therapeutic drug delivery as well as a component of multimodal therapies for tissue regeneration.

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Carbon nanotubes in drug delivery: focus on infectious diseases

Cited by 61 publications

References 107 publications

Synergistic and competitive adsorption of organic dyes on multiwalled carbon nanotubes

Synergistic and competitive adsorption of organic dyes on multiwalled carbon nanotubes

Advancement in carbon nanotubes: basics, biomedical applications and toxicity

Advances in use of functionalized carbon nanotubes for drug design and discovery

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