Carbon Nanotubes—Potential of Use for Deep Bioimaging

Onoda, Atsuto; Umezawa, Masakazu

doi:10.1007/978-981-15-9627-8_5

Cited by 3 publications

(1 citation statement)

References 93 publications

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“…Single-walled carbon nanotubes (SCNTs) enable in vivo deep imaging in the NIR-II region [ 60 ]. Its optical properties show unique one-dimensional aspects, such as optical transitions between van Hove singularities, large exciton effects and length-dependent plasmon absorptions [ 61 , 62 , 63 , 64 ].…”

Section: Nanoprobes For Tam Imaging and Therapymentioning

confidence: 99%

Targeting Tumor-Associated Macrophages for Imaging

2022

Pharmaceutics

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As an important component of the tumor immune microenvironment (TIME), tumor-associated macrophages (TAMs) occupy a significant niche in tumor margin aggregation and respond to changes in the TIME. Thus, targeting TAMs is important for tumor monitoring, surgical guidance and efficacy evaluation. Continuously developing nanoprobes and imaging agents paves the way toward targeting TAMs for precise imaging and diagnosis. This review summarizes the commonly used nanomaterials for TAM targeting imaging probes, including metal-based nanoprobes (iron, manganese, gold, silver), fluorine-19-based nanoprobes, radiolabeled agents, near-infrared fluorescence dyes and ultrasonic nanobubbles. Additionally, the prospects and challenges of designing nanomaterials for imaging and diagnosis (targeting efficiency, pharmacokinetics, and surgery guidance) are described in this review. Notwithstanding, TAM-targeting nanoplatforms provide great potential for imaging, diagnosis and therapy with a greater possibility of clinical transformation.

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Section: Nanoprobes For Tam Imaging and Therapymentioning

confidence: 99%

Targeting Tumor-Associated Macrophages for Imaging

2022

Pharmaceutics

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Controlling Molecular Dye Encapsulation in the Hydrophobic Core of Core–Shell Nanoparticles for In Vivo Imaging

Umezawa

Ueya²,

Ichihashi

et al. 2023

Biomedical Materials & Devices

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Polymeric nanoparticles with a hydrophobic core are valuable biomedical materials with potential applications in in vivo imaging and drug delivery. These materials are effective at protecting vulnerable molecules, enabling them to serve their functions in hydrophilic physiological environments; however, strategies that allow the chemical composition and molecular weight of polymers to be tuned, forming nanoparticles to control the functional molecules, are lacking. In this article, we review strategies for designing core–shell nanoparticles that enable the effective and stable encapsulation of functional molecules for biomedical applications. IR-1061, which changes its optical properties in response to the microenvironment are useful for in vitro screening of the in vivo stability of polymeric nanoparticles. An in vitro screening test can be performed by dispersing IR-1061-encapsulated polymer nanoparticles in water, saline, buffer solution, aqueous protein solution, etc., and measuring the absorption spectral changes. Through the screening, the effects of the polarity, molecular weight, and the chiral structure of polymers consisting of polymer nanoparticles on their stability have been revealed. Based on the findings presented here, more methodologies for the effective application of various biomolecules and macromolecules with complex high-dimensional structures are expected to be developed.

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