The coexistence of biomolecules in the living being blood, and urine plays a crucial function in the biological systems. For i.e., in human organism, generally there coexist Ascorbic Acid (AA) and Dopamine (DA) in the extracellular fluid. Moreover, in the human’s blood and urine, it coexists Uric Acid (UA) and (AA). Therefore, these compounds are of great interest in biomedical function which play a essential factor in the human metabolism, central nervous, renal systems, and beyond. However, abnormal levels of these molecules can lead to a drop-off in the biological system purpose. So, that, since long time ego, as described here, there are many materials in diverse forms that have been designed and developed for both biomolecules oxidation and detection. However, it still some issues to master this concern such the materials costs, the process optimization and cost, the environmental friendliness of the suggested catalysts, and so on. Therefore, there is a higher need in the development of a new and powerful platforms for the early and facile sensing of these biomolecules with cost- effective, high selectivity, as well as best sensitivity, superior stability.