Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats

Rakhmatia, Yunia Dwi; Ayukawa, Yasunori; Furuhashi, Akihiro; Koyano, Kiyoshi

doi:10.3390/ma11071201

Cited by 13 publications

(11 citation statements)

References 45 publications

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“…Hydroxyapatite (Ca10(PO4)6(OH)2) can remineralize lost or damaged bone tissue without causing a rejection reaction by the body. Bioactive properties of hydroxyapatite can help bind them to bone tissue and provide specific biological responses that can stimulate osteoblast cells to produce new bone tissue so that it can help the process of bone regeneration [8,31]. Analysis with SAA showed a hydroxyapatite surface area of 0.50 m 2 /g, a pore size of 123.20 nm, and a pore volume of 31.02 mm 3 /g.…”

Section: Discussionmentioning

confidence: 99%

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Kamadjaja¹,

Tumali²,

Laksono³

et al. 2020

Recent Advances in Biology and Medicine

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Tooth extraction can cause 1.5-2 mm (vertical) and 40-50% (horizontal) alveolar bone resorption to occur for 6 months after extraction and will continue if it is not treated. Alveolar bone resorption will affect the retention, stability, and comfort in the use of dentures because adequate alveolar bone volume and structure of alveolar ridge are very important to obtain optimal function and prosthetic reconstruction. Currently, there are techniques and materials that can be used to minimize bone resorption. Preservation of alveolar ridges with crab shell-based hydroxyapatite can minimize bone resorption because it has good biocompatibility, osteoconduction, and osteoinduction. The aim of this study is to prove the effectiveness of hydroxyapatite from crab shells in increasing the area of bone trabeculae, transforming growth factor-beta 1(TGF-β1), and alkaline phosphatase (ALP). This laboratory research is an experimental laboratory work with a post-test group design. Crab shell-based hydroxyapatite gel (Portunus pelagicus) was given after the post-tooth socket extraction of the left lower central incisor of Wistar rats, observing the area of trabeculae, TGF-β1, and ALP on the 14th day and 28th day. Hydroxyapatite is made from the calcination process of crab shells using a furnace at 1000°C for 2 h followed by sifting to powder. The powder is added with carrageenan and distilled water so that it becomes a gel preparation. The results of this study were analyzed using the One-way ANOVA test with IBM SPSS version 20. The area of trabeculae, TGF-β1, and ALP between the control group and the treatment group showed p<0.05, which means there were significant differences between the groups. The study showed that hydroxyapatite from the crab shell (P. pelagicus) can increase the area of trabeculae, TGF-β1, and ALP in the post-extraction socket of Wistar rat’s teeth.

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Section: Discussionmentioning

confidence: 99%

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Kamadjaja¹,

Tumali²,

Laksono³

et al. 2020

Recent Advances in Biology and Medicine

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“…The meta-analysis research conducted by Bassir et al (2018) concluded that the preservation of alveolar bone using bone graft material effectively minimizes the reduction in the vertical and horizontal dimensions of post-extraction alveolar bone [4]. Alveolar bone preservation using bioactive ingredients is also expected to accelerate the time required for post-extraction bone healing for prosthodontic purposes [27].…”

Section: Alveolar Bone Preservationmentioning

confidence: 99%

Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin on Bone Graft Materials for Alveolar Bone Preservation

Pascawinata

Bakar

2022

Open Access Maced J Med Sci

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Alveolar bone resorption is one of post-extraction complications with a reduction in the dimensions and quality of the alveolar bone, which will make it challenging to install dental implants in the future. The resorption can be prevented by preserving the alveolar bone using bone grafts. Nanocrystalline hydroxyapatite (HA) is a widely developed material as a bone graft. However, there are still some limitations because it only has osteoconductive properties. The addition of injectable platelet-rich fibrin to HA can increase this material’s osteoinductive, antibacterial, and anti-inflammatory properties, making it suitable for use as bone graft material for the preservation of alveolar bone.

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“…In the paper by Rakhmatia et al [12], an investigation into how statins can enhance bone formation was carried out. This was executed by evaluating how readily apatite blocks made via a dissolution-reprecipitation reaction, involving preset gypsum in the presence and absence of statins, could increase bone formation in a socket healing scenario after tooth extraction.…”

Section: Synopsis Of Papers Contributed To the Special Issuementioning

confidence: 99%

Special Issue: Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates

Mucalo

2019

Materials

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Research on calcium phosphate use in the development and clinical application of biomedical materials is a diverse activity and is genuinely interdisciplinary, with much work leading to innovative solutions for improvement of health outcomes. This Special Issue aimed to summarize current advances in this area. The nine papers published cover a wide spectrum of topical areas, such as (1) remineralisation pastes for decalcified teeth, (2) use of statins to enhance bone formation, (3) how dolomitic marble and seashells can be processed into bioceramic materials, (4) relationships between the roughness of calcium phosphate surfaces and surface charge with the effect on human MRC osteogenic differentiation and maturation being investigated, (5) rheological and mechanical properties of a novel injectable bone substitute, (6) improving strength of bone cements by incorporating reinforcing chemically modified fibres, (7) using adipose stem cells to stimulate osteogenesis, osteoinduction, and angiogenesis on calcium phosphates, (8) using glow discharge treatments to remove surface contaminants from biomedical materials to enhance cell attachment and improve bone generation, and (9) a review on how classically brittle hydroxyapatite based scaffolds can be improved by making fibre-hydroxyapatite composites, with detailed analysis of ceramic crack propagation mechanisms and its prevention via fibre incorporation in the hydroxyapatite.

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Carbonate Apatite Containing Statin Enhances Bone Formation in Healing Incisal Extraction Sockets in Rats

Cited by 13 publications

References 45 publications

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Effect of Socket Preservation Using Crab Shell-Based Hydroxyapatite in Wistar Rats

Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin on Bone Graft Materials for Alveolar Bone Preservation

Special Issue: Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates

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