2006
DOI: 10.1158/1535-7163.mct-06-0089
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Carboplatin nanocapsules: a highly cytotoxic, phospholipid-based formulation of carboplatin

Abstract: Platinum-based drugs are widely used in cancer chemotherapy. However, their clinical use is limited by systemic toxicity, rapid blood clearance, and the occurrence of resistance. Our research is aimed at increasing the therapeutic index of these drugs by encapsulation in a lipid formulation. Previously, we developed a method for efficient encapsulation of cisplatin in a lipid formulation, yielding cisplatin nanocapsules. Here, we show that carboplatin, a cisplatin-derived anticancer drug with different chemica… Show more

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Cited by 48 publications
(34 citation statements)
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“…The encapsulation in nanocapsules strongly improves the cytotoxicity of carboplatin towards ovarian, renal and non-small-cell lung carcinoma cells in vitro [56]. The improved cytotoxicity of the carboplatin nanocapsules was found to be due to an increase in cellular accumulation of the drug after treatment with the nanocapsules as compared with the accumulation in cells treated with free carboplatin [56].…”
Section: Review -Hamelers and De Kroonmentioning
confidence: 95%
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“…The encapsulation in nanocapsules strongly improves the cytotoxicity of carboplatin towards ovarian, renal and non-small-cell lung carcinoma cells in vitro [56]. The improved cytotoxicity of the carboplatin nanocapsules was found to be due to an increase in cellular accumulation of the drug after treatment with the nanocapsules as compared with the accumulation in cells treated with free carboplatin [56].…”
Section: Review -Hamelers and De Kroonmentioning
confidence: 95%
“…The improved cytotoxicity of the carboplatin nanocapsules was found to be due to an increase in cellular accumulation of the drug after treatment with the nanocapsules as compared with the accumulation in cells treated with free carboplatin [56]. Like the formation of cisplatin nanocapsules, the formation of carboplatin nanocapsules strictly depends on the freeze-thaw steps and the presence of negatively charged lipids [56]. However, there are also some obvious differences in the nanocapsule formulations of cisplatin and carboplatin: the drug-to-lipid molar ratio of the carboplatin nanocapsules is much lower (0.72:1; [56]) than that of the cisplatin nanocapsules (11:1; [52]).…”
Section: Review -Hamelers and De Kroonmentioning
confidence: 97%
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