Carbopol-olive oil-based bigel drug delivery system of doxycycline hyclate for the treatment of acne

Soni, Kumud; Gour, Vishal; Agrawal, Poornima; Haider, Tanweer; Kanwar, Indu Lata; Bakshi, Avijit Kumar; Soni, Vandana

doi:10.1080/03639045.2021.1957916

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…The particles containing ROX and Nile red showed markedly enhanced follicular penetration behavior in both a water suspension and an organogel compared to an oily solution (Figure ). In another study, a combination hydrogel and organogel approach was implemented for the formation of bigels containing doxycycline hyclate for the treatment of acne . The studies showed that the microstructured size of the bigels was within the range of 15–50 mm, which was considered optimal for ensuring stability and uniformity in the formulation.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

“…In another study, a combination hydrogel and organogel approach was implemented for the formation of bigels containing doxycycline hyclate for the treatment of acne. 192 The studies showed that the microstructured size of the bigels was within the range of 15–50 mm, which was considered optimal for ensuring stability and uniformity in the formulation. The findings from drug release studies indicated that the bigel formulation had a greater efficacy in terms of achieving a controlled and sustained drug release pattern.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

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Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

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Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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“…Bigels have been studied in the last decade for pharmaceutical and cosmetic purposes, and several publications demonstrate the success and efficiency of these applications (Hamed et al, 2020; Maji et al, 2021; Soni et al, 2021). In recent years, they have gained traction in the food science field due to their potential use as a fat replacer and reducer.…”

Section: Oleogels and Bigels As Potential Saturated Fat Replacersmentioning

confidence: 99%

Oleogels and bigels as alternatives to saturated fats: A review on their application by the food industry

Silva

Cerqueira

Martins

et al. 2022

J Americ Oil Chem Soc

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The nutritional quality of processed foods is being increasingly questioned by consumers and the trend toward diets that promote health and well‐being has thus grown significantly. With this in mind, food science has sought to develop products replacing ingredients that can be harmful to consumers. This is not an easy task because, besides health‐ and well‐being‐related issues (e.g., nutritional and eventual nutraceutical properties), the new products must also meet consumers' expectations regarding sensory attributes (e.g., flavor, texture, color), while also complying with the legal regulations of the countries where they are supposed to be sold. These aspects are addressed in this article, with a special focus on the replacement of saturated fats by healthier options. Although saturated fats play an important role in many foods, as a consequence of their technological and organoleptic properties, consumption of saturated fats has been correlated with serious health issues. These factors highlight the need to replace saturated fats with healthier alternatives. One of the options to improve upon these problems is the use of edible structured oils that display a healthier fatty acid profile. As such, the development of oleogels and bigels has been of great interest as a solution for the replacement of saturated fat, and will be explored in‐depth in this review.

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“…The mixing of the aforesaid gelled systems leads to the formation of biphasic systems, which are structurally similar to emulsions [ 5 ]. However, unlike emulsions, bigels are semisolid in nature [ 6 ]. Depending on the distribution of the gelled systems, bigels are categorized either as oleogel-in-hydrogel or hydrogel-in-oleogel [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the distribution of the gelled systems, bigels are categorized either as oleogel-in-hydrogel or hydrogel-in-oleogel [ 2 ]. Moreover, some authors have reported the formation of bi-continuous bigel [ 2 , 6 ]. This type of bigel does not have either a clearly dispersed or continuum phase.…”

Section: Introductionmentioning

confidence: 99%

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

Shaikh

Anis

Poulose

et al. 2022

Gels

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Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.

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Carbopol-olive oil-based bigel drug delivery system of doxycycline hyclate for the treatment of acne

Cited by 13 publications

References 35 publications

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Oleogels and bigels as alternatives to saturated fats: A review on their application by the food industry

Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin

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