Carbopol®-crospovidone interpolymer complex for pH-dependent desloratadine release

Szakonyi, Gergely; Zelkó, Romána

doi:10.1016/j.jpba.2016.02.012

Cited by 10 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some less intense bands at 1113.37 and 1051.36 cm −1 (due to O-H deformations) have been observed. [39][40][41] 13 C NMR spectra of CP and CP-cl-poly(NVP) polymer are presented in Figure 4. In case of CPan intense splitted peak at 183.49, 179.90 ppm [due to carbon ofcarbonyl groups] and another intense but broad peak at 42.57 ppm [due to methylene (-CH 2 -CH-) and methine (-CH 2 -CH-) groups of acrylic chains] has been observed.…”

Section: Characterizationmentioning

confidence: 99%

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh

Dhiman

2019

J Pharm Biopharm Res

View full text Add to dashboard Cite

In the present work an attempt has been made to design the antibiotic drug loaded carbopolpoly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13 CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31g/g of polymer film. The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models. Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm −2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.

show abstract

Section: Characterizationmentioning

confidence: 99%

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh

Dhiman

2019

J Pharm Biopharm Res

View full text Add to dashboard Cite

show abstract

“…Clearly, POZ and C971 dispersed uniformly in the intact tablet prior to hydration, as reflected by the presence of their characteristic peaks with high intensities in the spectrum of PM, such as the peak of the carboxyl stretching band of C971 (1704 cm -1 ) and a "shoulder" of amide I of POZ (1633 cm -1 ). According to above discussed mechanism of IPCs formation and also the literature data (Takayama and Nagai, 1987;Satoh et al, 1989;Ozeki et al, 1998aOzeki et al, , 1998bTan et al, 2001;Zhang et al, 2016aZhang et al, , 2016bYusif et al, 2016;Szakonyi andZelko, 2016, Nguyen et al, 2016), the passage of the tablets through pH 1.2 media facilitates strong interaction between the polymers. However, the spectral and thermal analysis results did not provide any evidence for the complexation under these conditions: the band corresponding to the self-associated carboxylic groups (COOH) located at 1704 cm -1 showed a very minor shift to 1707 cm -1 and the presence of amide I stretching was observed at 1622 cm -1 ; Tg values at 51.7±0.9 o C and 131.9±0.8 o C observed are assigned to the pure POZ 50 kDa and C971, respectively.…”

Section: (Table 1 Is Here)mentioning

confidence: 82%

“…Despite that diffusion of POZ 500 kDa from non-hydrated core to the gel layer may be slower due to its high molecular weight, compared to PM made from POZ 50 kDa, drug release process may proceed differently. It is known that hydrogen bonds in IPC matrices help increasing the gel strength to improve the release-retarding capacity of polymer matrix (Tan et al, 2001;Zhang et al, 2015Zhang et al, , 2016Yusif et al, 2016;Szakonyi andZelko, 2016, Nguyen et al, 2016).…”

Section: Drug Release Studiesmentioning

confidence: 99%

Interpolymer complexes of carbopol® 971 and poly(2-ethyl-2-oxazoline): Physicochemical studies of complexation and formulations for oral drug delivery

Moustafine

Viktorova

Khutoryanskiy

2019

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Frequency shift from 3446 cm -1 (in ATR-FTIR belonging to crospovidone) to lower frequency at 3437 cm -1 in ATR-FTIR belonging to co-processed crospovidone indicated hydrogen bonding between them [15][16][17][18].…”

Section: Figure 1 Atr-ftir Of Dried Hydrogelmentioning

confidence: 96%

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Hardikar¹,

Patil²

2022

Int J Pharm Phytopharmacol Res

View full text Add to dashboard Cite

Established disintegrating agents possess the disintegrating ability only and they rarely assist in the compactibility of powder blend except for starch. Many of the reported binders are proven to retard the release rate of the active drug from the dosage forms. Therefore the present work was aimed at developing a coprocessed binder-disintegrant to overcome these functional drawbacks of the binders and disintegrating agents. The novel binder-disintegrant was prepared by co-processing crospovidone and the gel obtained from the husk of Plantago Ovata seeds. To confirm the functionality of the novel co-processed binder-disintegrant under investigation; paracetamol was selected as a model drug. The absence of chemical interaction between the co-processed materials and the formation of hydrogen bonding between them was confirmed by the analytical technique of ATR-FTIR. The functionality of the co-processed material as a granulation binder was confirmed by the Heckel treatment. The linear relationship between ln (1/1-D) and compression pressure applied on the paracetamol tablets, confirmed the functionality of co-processed material as a granulation binder. These tablets were prepared by adding the novel co-processed granulation binder-disintegrant intragranularly at 5%. The functionality of novel co-processed material as a disintegrating agent was confirmed by analyzing the results of disintegration and dissolution studies of the paracetamol tablets. Paracetamol tablets exhibited faster disintegration when crospovidone was added extra granularly; than when a novel co-processed binder disintegrant was added. Thus, the functionality of the novel binder disintegrant was investigated by assessing the performance of the formulation of immediate-release tablets of paracetamol.

show abstract

Carbopol®-crospovidone interpolymer complex for pH-dependent desloratadine release

Cited by 10 publications

References 15 publications

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Interpolymer complexes of carbopol® 971 and poly(2-ethyl-2-oxazoline): Physicochemical studies of complexation and formulations for oral drug delivery

Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant

Contact Info

Product

Resources

About