Carbosilane Metallodendrimers with Titanocene Dichloride End Groups

Abstract

Carbosilane metallodendrimers containing substituted titanocene dichloride end groups were prepared using hydrosilylation as the capping reaction. Two complementary pathways were followed: hydrosilylation of ω-alkenyl-substituted titanocene dichloride complexes with Si–H bond terminated dendrimers and hydrosilylation of vinyl terminated dendritic materials with 3-(dimethylsilyl)propyl-substituted titanocene dichloride. The former procedure provided dendrimers of the first generation with four end units and of the second generation with eight end units. The latter method gave dendrititic wedges and dendrimers up to the second generation with 16 peripheral titanocene dichloride units and molecular weight 7070 Da. Dendritic materials were purified by GPC and characterized by MALDI-TOF mass spectrometry and ESI-TOF mass spectrometry (metallodendrimers) and also by multinuclear NMR.

Structure–activity relationship study of cationic carbosilane dendritic systems as antibacterial agents

“…The synthesis of the new compounds was started using carbosilane dendrimers decorated with vinyl moieties G n SiV m . 43 In a first step, these compounds were modified by thiol-ene reactions employing 2- chain formed. Furthermore, 1 H, 13 C and 15 N NMR spectroscopy of compounds 7S-9S also revealed the outermost S(CH 2 ) 2 NMe 3 + chain.…”

“…The synthesis of the new compounds was started using carbosilane dendrimers decorated with vinyl moieties G n SiV m . 43 In a rst step, these compounds were modied by thiol-ene reactions employing 2-dimethylaminoethanethiol hydrochloride, HS(CH 2 ) 2 NMe 2 $HCl,…”

“…Compounds, HS(CH 2 ) 2 NH 2 $HCl (Acros), HS(CH 2 ) 2 -NMe 2 $HCl (Acros), 2,2 0 -dimethoxy-2-phenylacetophenone (DMPA) (Aldrich), MeI (Aldrich), K 2 CO 3 (Panreac) were obtained from commercial sources. Compounds G n SiV m , 43 39 BrG n V m , 59 XGn(NMe 2 $HCl) m (X ¼ N 3 , HOC 6 H 4 O, Pht), 59 [NH 2 G n (S-NMe 3 ) m ] m+1 (31S-33S), 45 and [G 0 Si(S-NH 3 ) 4 ] 2+ (10S) 44 were synthesized as published.…”

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

“…Sulfuric acid was purchased from Hanssell (Madrid, Spain). Vinyl-decorated dendrimer Si-G1V 8 ( D1 ) and dendrons N 3 -G3V 8 ( D2 ) and HO-G3V 8 ( D3 ) were synthesized as previously reported [ 20 , 21 ].…”

Synthesis and characterization of carbosilane dendrimer–sodium montmorillonite clay nanocomposites. Experimental and theoretical studies

“…Dendrimers Dm1 with four and Dm2 with eight cationic groups on their periphery were prepared by synthetic modication of substrates which we previously used as a scaffold for titanium complexes. 19,20 For investigation of interaction of dendrimers with montmorillonite we used a variety of relevant experimental approaches. We found considerable differences between Dm1 and Dm2 dendrimers during intercalation process into the inorganic layers.…”