Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking

Abstract

pH-responsive capsule particles show promise for various applications, such as self-healing materials, micro/nanoreactors, and drug delivery systems. Herein, carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were...

Development of Drug-Loaded PCL@MOF Film Enclosed in a Photo Polymeric Container for Sustained Release

“…Among the various external parameters, pH is considered a significant factor due to variable pH conditions in the physiological system, which can facilitate drug release. Several pH-sensitive polymeric hydrogels with pH labile functional groups (e.g., hydrazone/amine/carboxylic/sulfonyl) have been prepared as oral dosage forms for drug release in the gastrointestinal tract. ,,− Acidic polyelectrolytes such as polymethyl acrylic ethylene glycol, cationic polymers such as aminoalkyl methacrylate copolymer (Eudragit E), and polyvinylacetal diethylaminoacetate (AEA) are sensitive to acidic pH; anionic polyelectrolytes such as poly(methacrylic acid–methyl methacrylate) (e.g., Eudragit L, S, and F) respond favorably to a basic medium. , These excipients also perform a taste-masking function in drug formulations. ,− …”

pH-Responsive Capsules Fabricated by Interfacial Photo-Cross-Linking Utilizing the Photoreactivity and pH-Responsiveness of Thymine

“…The interfacial photoreaction led to shell-selective cross-linking of the polymer particles, and removing the non-cross-linked core polymers yielded hollow polymer particles. The polymer shell thickness of the hollow polymer particles could be regulated by changing the photoirradiation time and intensity. , Furthermore, capsule polymer particles were successfully prepared from hollow polymer particles by a posteriori encapsulation of various molecules. − To date, several photoreactive groups, such as cinnamate and coumarin, have been applied to interfacial photo-cross-linking. , Using interfacial photo-cross-linking, pH-responsive capsules have been successfully prepared by copolymerizing additional pH-responsive monomers with photoreactive monomers. , …”

“…33−35 To date, several photoreactive groups, such as cinnamate and coumarin, have been applied to interfacial photo-cross-linking. 36,37 Using interfacial photocross-linking, pH-responsive capsules have been successfully prepared by copolymerizing additional pH-responsive monomers with photoreactive monomers. 34,35 Nucleobases such as thymine and uracil possess a photoreactive alkene group.…”