Carboxyl graphene modified PEDOT:PSS organic electrochemical transistor for in situ detection of cancer cell morphology

Song, Qingyuan; Liu, Hongni; Wang, Weiyi; Chen, Chaohui; Cao, Yiping; Chen, Bolei; Cai, Bo; He, Rongxiang

doi:10.1039/d3nr06190f

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…Furthermore, the sensor has high selectivity and anti-interference capability, and highlighted its potential utilization for future clinical cancer diagnostics. Song et al [ 301 ] developed an organic electrochemical biosensor for in situ detection of cancer cells in blood. This sensor was fabricated by carboxyl graphene mixed with PEDOT:PSS.…”

Section: Electrochemical Sensing Of Biomoleculesmentioning

confidence: 99%

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors to biomolecules, requiring adept conversion and amplification of interactions into various signal modalities like electrical, optical, gravimetric, and electrochemical outputs. Overcoming challenges associated with sensitivity, detection limits, response time, reproducibility, and stability is essential for efficient biosensor creation. The central aspect of the fabrication of any biosensor is focused towards forming an effective interface between the analyte electrode which significantly influences the overall biosensor quality. Polymers and macromolecular systems are favored for their distinct properties and versatile applications. Enhancing the properties and conductivity of these systems can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing a unique combination of attributes like advanced sensitivity, selectivity, thermal stability, mechanical flexibility, biocompatibility, and tunable electrical properties, emerge as promising candidates for biosensor applications. In addition, this approach enhances the electrochemical response, signal amplification, and stability of fabricated biosensors, contributing to their effectiveness. This review predominantly explores recent advancements in utilizing macrocyclic and macromolecular conjugated systems, such as phthalocyanines, porphyrins, polymers, etc. and their hybrids, with a specific focus on signal amplification in biosensors. It comprehensively covers synthetic strategies, properties, working mechanisms, and the potential of these systems for detecting biomolecules like glucose, hydrogen peroxide, uric acid, ascorbic acid, dopamine, cholesterol, amino acids, and cancer cells. Furthermore, this review delves into the progress made, elucidating the mechanisms responsible for signal amplification. The Conclusion addresses the challenges and future directions of macromolecule-based hybrids in biosensor applications, providing a concise overview of this evolving field. The narrative emphasizes the importance of biosensor technology advancement, illustrating the role of smart design and material enhancement in improving performance across various domains.

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Section: Electrochemical Sensing Of Biomoleculesmentioning

confidence: 99%

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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Recent Progress in Organic Electrochemical Transistor-Structured Biosensors

Hu,

Huang

et al. 2024

Biosensors

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The continued advancement of organic electronic technology will establish organic electrochemical transistors as pivotal instruments in the field of biological detection. Here, we present a comprehensive review of the state-of-the-art technology and advancements in the use of organic electrochemical transistors as biosensors. This review provides an in-depth analysis of the diverse modification materials, methods, and mechanisms utilized in organic electrochemical transistor-structured biosensors (OETBs) for the selective detection of a wide range of target analyte encompassing electroactive species, electro-inactive species, and cancer cells. Recent advances in OETBs for use in sensing systems and wearable and implantable applications are also briefly introduced. Finally, challenges and opportunities in the field are discussed.

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A Preliminary Analysis of Circulating Tumor Microemboli from Breast Cancer Patients during Follow-Up Visits

Lai,

Huang,

Hao

et al. 2024

Current Oncology

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Background: Most breast cancer-related deaths are caused by distant metastases and drug resistance. It is important to find appropriate biomarkers to monitor the disease and to predict patient responses after treatment early and accurately. Many studies have found that clustered circulating tumor cells, with more correlations with metastatic cancer and poor survival of patients than individual ones, are promising biomarkers. Methods: Eighty samples from eleven patients with breast cancer during follow-up visits were examined. By using a microfluidic chip and imaging system, the number of circulating tumor cells and microemboli (CTC/CTM) were counted to assess the distribution in stratified patients and the potential in predicting the disease condition of patients after treatments during follow-up visits. Specific components and subtypes of CTM were also preliminarily investigated. Results: Compared to CTC, CTM displayed a distinguishable distribution in stratified patients, having a better AUC value, in predicting the disease progression of breast cancer patients during follow-up visits in this study. Four subtypes were categorized from the identified CTM by considering different components. In combination with CEA and CA153, enumerated CTC and CTM from individual patients were applied to monitor the disease condition and patient response to the therapy during follow-up visits. Conclusions: The CTM and its subtypes are promising biomarkers and valuable tools for studying cancer metastasis and longitudinally monitoring cancer patients during follow-up visits.

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Carboxyl graphene modified PEDOT:PSS organic electrochemical transistor for in situ detection of cancer cell morphology

Abstract: Circulating tumor cells in human peripheral blood plays an important role in cancer metastatic. In addition to the size-based and antibody-based cancer cells capture and separation, the electric characterization of...

Cited by 3 publications

References 53 publications

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Recent Progress in Organic Electrochemical Transistor-Structured Biosensors

A Preliminary Analysis of Circulating Tumor Microemboli from Breast Cancer Patients during Follow-Up Visits

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