Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans

Photoaged Nanopolystyrene Affects Neurotransmission to Induce Transgenerational Neurotoxicity in Caenorhabditis elegans

“…22 Similarly, abnormal neurotransmission has been associated with the neurotoxicity resulting from the exposure of nematodes to carboxyl-modified MPs. 23 In a previous study from our group, exposure to MPs has been shown to cause neurobehavioral defects associated with alterations in neurotransmission in C. elegans. 24 In the present study, the exposure concentration of NPS was set at 0.1−100 μg/L based on the concentration ranges of NPS in the environment.…”

“…Exposure to microplastics (MPs) results in neurological abnormalities, which ultimately lead to neurotoxicity. , A recent study has shown that exposure to photoaged MPs results in behavioral deficits in nematodes by influencing serotonin, dopamine, and glutamate neurotransmission . Similarly, abnormal neurotransmission has been associated with the neurotoxicity resulting from the exposure of nematodes to carboxyl-modified MPs . In a previous study from our group, exposure to MPs has been shown to cause neurobehavioral defects associated with alterations in neurotransmission in C.…”

“…21 A previous study from our group demonstrated that UV-aged MPs induce neurotoxicity and damage dopaminergic, glutamatergic, and serotonergic neurons in C. elegans; 24 these neuronal damages could possibly play a role in behavioral deficits in nematodes exposed to carboxyl-modified MPs. 23 Another study suggested that the arsenic-induced transgenerational effects on behavior could be associated with damage to dopaminergic neurons in C. elegans. 44 Thus, parental exposure to P-NPS results in neuronal damage-mediated transgenerational neurotoxicity in subsequent generations of nematodes.…”

“…45 Moreover, neurobehavioral defects induced by MPs are likely due to disruptions in the dopamine, glutamate, and serotonin pathways. 23,24 A recent study reported that exposure to photoaged MPs decreased levels of these neurotransmitters and the expression of neurotransmission-related genes (e.g., dat-1, eat-4, and tph-1) in C. elegans. 22 Notably, parental exposure to nonylphenol ethoxylate significantly decreased the expression of dat-1 and eat-4 in the F1 generation, demonstrating transgenerational toxicity through alterations in glutamate and dopamine pathways in C. elegans.…”

Direct Quantification of Nanoplastics Neurotoxicity by Single‐Vesicle Electrochemistry

“…[12][13][14][15] Given that nanoplastics can directly penetrate the blood-brain barrier (BBB) and accumulate in the central nervous system (CNS), [16][17] great concerns about their potential effects on neuronal activities and brain functions and possible link to neurodegenerative diseases as well are therefore rapidly growing. [18][19] Recent studies suggest that nanoplastics could affect the basal levels of neurotransmitters in vivo [20][21] and learning/memory abilities of mice. [22] Vesicles are the smallest organelles executing neurotransmission functions by fusing with presynaptic membranes and releasing neurotransmitters into the synaptic cleft to elicit postsynaptic depolarization and action potential propagation.…”