Carboxylate-bridged Cu(II) coordination polymeric complex: synthesis, crystal structure, magnetic properties, DNA binding and electrochemical studies

Abstract

A novel water-soluble carboxylate-bridged copper(II) coordination polymer, Cu-BIG was formed by the reaction of Cu(ClO 4) 2 • 6H 2 O and tridentate benzimidazole-glycine conjugate ligand, 2-((1H-benzimidazol-2-yl)methylamino) acetic acid, BIGH and its structure has been determined by IR, UV, powder XRD, VSM, CV, TGA, DTA, EPR and single crystal X-ray diffraction. Crystallographic studies indicate it to be a coordination polymer with Pī Space group. The asymmetric unit of complex contains two Cu(II) ions with elongated square pyramid geometry. The axial positions of the Cu(II) atoms are occupied by the carbonyl oxygen of the carboxylate group with the bond distances Cu(1)-O(5) axial , 2.28 Å, and Cu(2)-O(2) axial , 2.26 Å. The two Cu(II) are connected through the carboxylic group present in BIGH, which provides electron mobilisation in the molecule and hence results in the soft ferromagnetic polymer. An in vitro antibacterial activity study of BIGH and Cu-BIG showed moderate activity against Bacillus subtilis. The DNA binding studies showed the interaction of Cu-BIG with CT-DNA.

A novel Mn(II) oxalato-bridged 2D coordination polymer: synthesis, crystal structure, spectroscopic, thermal and magnetic properties

“…Coordination polymers (CPs) are of rising interest because of their fascinating topologies and dimensionality associated with both structural and functional versatility. Various attempts to build high-dimensional CPs with intriguing architectures were successful through the multitude of N-donor ligands such as 1,10-phenanthroline derivatives, 1 benzidine ligand 2 and dipyridylbased ligand 3,4 as well as O-donor ligands including o-phthalic acid 5 and carboxylic acid, 6 due to their excellent coordinating ability. And among this wide variety of ligands, the oxalate ion was proven to be one of the most useful ligand, and played a prominent role by conferring electronic, 7 photochemical, 8 magnetic 9 and optical 10 properties on those materials.…”

Synthesis, characterisation, nuclease and cytotoxic activity of phosphate-free and phosphate-containing copper $$4^{\prime }$$ 4 ′ -(N-methylpyridinium)- $$2{,}2^{\prime }{:}6^{\prime }{,}2^{\prime \prime }$$ 2 , 2 ′ : 6 ′ , 2 ″ terpyridine complexes

“…17,18 To overcome these clinical problems many efforts have been made to synthesize several transition metal complexes of Cu(II), Fe(III), Ru(II), Co(III), Zn(II) and Ni(II) which could act as substitute to anti-cancer drugs with lesser side effects. [19][20][21][22][23][24] Among all these metals, the biocompatible nature of Cu(II) complexes makes them better candidates as pharmacological agents in biological systems. 25 Also, the level of copper in the serum correlates with tumor incidence, tumor volume, degree of malignancy and recurrence in various human cancers including sarcoma, leukemia, Hodgkin's lymphoma, brain tumours and cancer of the cervix, breast, liver and lung; supporting the hypothesis that copper could be used as a potential cancer-specific target.…”