Carboxylated or Aminated Polyaniline—Multiwalled Carbon Nanotubes Nanohybrids for Immobilization of Cellobiose Dehydrogenase on Gold Electrodes

Tanne, Johannes; Kracher, Daniel; Dietzel, Birgit; Schulz, Burkhard; Ludwig, Roland; Lisdat, Fred; Scheller, Frieder W.; Bier, Frank F.

doi:10.3390/bios4040370

Cited by 9 publications

(7 citation statements)

References 62 publications

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“…Another lactose-specific enzyme, cellobiose dehydrogenase, was utilized to construct an amperometric sensor for lactose . Here, the enzyme was immobilized onto a nanohybrid of poly(3-amino-4-methoxybenzoic acid- co -aniline) and MWCNTs followed by the deposition of the nanohybrid on the surface of a gold electrode.…”

Section: Electrochemical Analysis Of Small Moleculesmentioning

confidence: 99%

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Sargent²,

2016

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Rapid progress in identifying biomarkers that are hallmarks of disease has increased demand for high-performance detection technologies. Implementation of electrochemical methods in clinical analysis may provide an effective answer to the growing need for rapid, specific, inexpensive, and fully automated means of biomarker analysis. This Review summarizes advances from the past 5 years in the development of electrochemical sensors for clinically relevant biomolecules, including small molecules, nucleic acids, and proteins. Various sensing strategies are assessed according to their potential for reaching relevant limits of sensitivity, specificity, and degrees of multiplexing. Furthermore, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms into point-of-care solutions.

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Section: Electrochemical Analysis Of Small Moleculesmentioning

confidence: 99%

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Sargent²,

2016

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“…From the stretching region of carbonyl, the peak at 1685 and 1287 cm −1 is attributed to the ν(CO) stretch from the carboxylic group and CO stretching derived from carboxylic groups . The four peaks of CC from 1450 to 1610 cm −1 are resulted from benzene rings . The peak at 1364 cm −1 corresponds to the CH bending vibration δ (CH) .…”

Section: Resultsmentioning

confidence: 65%

Enhanced Photovoltaic Performance of CdS Quantum Dot‐Sensitized Solar Cells Using 4‐Tertbutylbenzoic Acid as Self‐Assembled Monolayer on ZnO Photoanode

Sun

Chen

Deng³

et al. 2017

Physica Status Solidi (a)

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A 4‐tertbutylbenzoic acid (BBA) self‐assembled monolayers (SAMs) layer derived from benzoic acid is fabricated on the surface of photoanodes with different spin‐coating cycles. The effects of BBA on the photovoltaic property of the device are investigated. The conversion efficiency of the photovoltaic property with BBA/ZnO photoanodes exhibits a 56% enhancement in comparison with solar cells with pure ZnO photoanodes. The enhancement of the conversion efficiency is attributed to two aspects. The first one is that BBA SAMs in CdS quantum dots‐sensitized solar cells can suppress recombination process of electron‐hole because BBA decreased the defects on ZnO surface. The second one is that energy barrier formed by BBA efficiently prevent electrons transfer to CdS quantum dots. Ultimately, the photovoltaic performance of solar cells increased after deposition of BBA SAMs layer. Our experimental method provides an effective method for increasing the conversion efficiency of new generation solar cell device.

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“…This sensor led to a linear detection for lactose concentrations and had 1.1 mM as LOD. The other lactose-specific enzyme, i.e., cellobiose dehydrogenase, was used to develop an amperometric-based lactose sensor [ 64 ]. The enzyme was made to attach with MWCNTs and poly(3-amino-4-methoxybenzoic acid-co-aniline) nanohybrid followed by its deposition on a gold electrode surface.…”

Section: Nanomaterial-based Biosensors For Metabolites Detectionmentioning

confidence: 99%

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

et al. 2022

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Metabolites are the intermediatory products of metabolic processes catalyzed by numerous enzymes found inside the cells. Detecting clinically relevant metabolites is important to understand their physiological and biological functions along with the evolving medical diagnostics. Rapid advances in detecting the tiny metabolites such as biomarkers that signify disease hallmarks have an immense need for high-performance identifying techniques. Low concentrations are found in biological fluids because the metabolites are difficult to dissolve in an aqueous medium. Therefore, the selective and sensitive study of metabolites as biomarkers in biological fluids is problematic. The different non-electrochemical and conventional methods need a long time of analysis, long sampling, high maintenance costs, and costly instrumentation. Hence, employing electrochemical techniques in clinical examination could efficiently meet the requirements of fully automated, inexpensive, specific, and quick means of biomarker detection. The electrochemical methods are broadly utilized in several emerging and established technologies, and electrochemical biosensors are employed to detect different metabolites. This review describes the advancement in electrochemical sensors developed for clinically associated human metabolites, including glucose, lactose, uric acid, urea, cholesterol, etc., and gut metabolites such as TMAO, TMA, and indole derivatives. Different sensing techniques are evaluated for their potential to achieve relevant degrees of multiplexing, specificity, and sensitivity limits. Moreover, we have also focused on the opportunities and remaining challenges for integrating the electrochemical sensor into the point-of-care (POC) devices.

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Carboxylated or Aminated Polyaniline—Multiwalled Carbon Nanotubes Nanohybrids for Immobilization of Cellobiose Dehydrogenase on Gold Electrodes

Cited by 9 publications

References 62 publications

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules

Enhanced Photovoltaic Performance of CdS Quantum Dot‐Sensitized Solar Cells Using 4‐Tertbutylbenzoic Acid as Self‐Assembled Monolayer on ZnO Photoanode

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

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