Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings

Li, Chengpeng; Luo, Xiaoyan; Li, Lefan; Cai, Ying; Li, Puwang

doi:10.1016/j.ijbiomac.2022.04.025

Cited by 38 publications

(22 citation statements)

References 48 publications

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“…The synthesized nanofiber could be effective for fibroblast cell proliferation. 99 Carboxymethyl CS−polycaprolactone-based electrospun nanofibers were developed and employed to enhance osteoinductivity. The developed scaffold showed favorable properties for human mesenchymal stem cell (hMSC) proliferation, which demonstrated its potency in the field of tissue and bone engineering.…”

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

“…They offer excellent targeting ability, higher drug loading, increased surface area, better stability, and suitable mechanical properties for pharmaceutical applications . Among the various chitosan derivatives, carboxymethyl chitosan and quaternized chitosan derivatives are widely employed in nanofiber synthesis. Nanofibers are mostly synthesized through electrospinning techniques, though other techniques are also employed, including phase separation, self-assembly, and nanofiber drawing methods .…”

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

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Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past few decades, chitosan (CS) has gained the attention of researchers investigating newer biomaterial-based carriers for drugs in pharmaceutical and biomedical research. Combined with its nontoxic behavior, biodegradability, and biocompatibility, chitosan has found widespread applications in the fields of drug delivery, tissue engineering, and cosmetics. As a novel drug carrier, chitosan is regarded as one of the promising biomaterials in the pharmaceutical industry. The extensive use of this cationic biopolysaccharide in the delivery of therapeutic agents has brought a few limitations of chitosan into the limelight. Various chemical modifications of chitosan can minimize these limitations and improve the efficacy of chitosan as a drug carrier. The effectiveness of several chemically modified chitosan derivatives, including trimethyl chitosan, thiolated chitosan, PEGylated chitosan, and other chitosan derivatives, has been investigated by many researchers for the controlled and target specific delivery of therapeutics. The chemically modified chitosan derivatives exhibited greater importance in the current scenario on drug delivery due to their solubility in wide range of media along with their interaction with pharmaceutically active ingredients. Chitosan derivatives have also attracted attention in several biomedical fields, including wound healing, hyperthermia therapy, tissue engineering, and bioadhesives. The present review narrates the sources and common physicochemical properties of chitosan, including several important synthetic modifications to obtain chemically modified chitosans and their applications in targetspecific drug delivery, along with several biomedical applications.

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Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

Section: Chitosan Derivative-based Nanocarriersmentioning

confidence: 99%

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Manna

Seth

Gupta

et al. 2023

ACS Biomater. Sci. Eng.

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“…The controlled enzymatic hydrolysis of starch forms β-cyclodextrin (β-CD), which has a truncated cone-shaped structure. [29,30] It could form non-covalent host-guest inclusion complexes with a variety of lipophilic molecules such as fatty oils due to its hydrophobic interior hole.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the use of inorganic particles such as silica, clay, and titanium dioxide as Pickering emulsifiers, some studies have modified cellulose, protein, and starch to increase biocompatibility. The controlled enzymatic hydrolysis of starch forms β‐cyclodextrin (β‐CD), which has a truncated cone‐shaped structure [29, 30] . It could form non‐covalent host‐guest inclusion complexes with a variety of lipophilic molecules such as fatty oils due to its hydrophobic interior hole.…”

Section: Introductionmentioning

confidence: 99%

Production and Characterization of Bio‐based Sponges Reinforced with Hypericum perforatum oil (St. John′s Wort Oil) via Pickering Emulsions for Wound Healing Applications

Parın

Deveci

2023

ChemistrySelect

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Hypericum perforatum oil (HPO) was known as Saint John's wort oil which has antibacterial properties for medicinal applications. (topically to heal wounds). In this study, Pickering sponges containing HPO have been stabilized using β-cyclodextrin (β-CD) natural substance while Polyvinyl alcohol/sodium carboxymethyl cellulose (PVA/CMC) polymer matrices. The β-CD/HPO inclusion complexes were added to the PVA/CMC sponges in various ratios (1 : 1, 1 : 4, and 1 : 8) and morphological, thermal and physical properties of sponges were investigated based on the ratios. SEM images revealed all Pickering PVA/CMC/HPO sponges has good porosity and PVA/CMC sponges containing (1 : 8 w/v) of β-CD/HPO indicated the highest porosity. Furthermore, existence of HPO in the sponges were confirmed by FT-IR analysis. Similarly, thermal stability is increased as the β-CD/HPO increased. Contact angle value rise from 12.7°to 89.9°as HPO concentration increased, and this value is the ideal hydrophobicity for the skin. Antibacterial efficiency showed good antibacterial activities of Pickering sponges containing the highest amount of HPO (1 : 8 w/v of β-CD/HPO) against Gram (À ) (Escherichia coli), and Gram (+) (Staphylococcus aureus, P. aeruginosa) bacteria with 13-17 mm zone inhibition diameter. All samples showed biocompatibility, and the material with the lowest amount of HPO (1 : 1 w/v of β-CD/HPO) having the best biocompatibility. The increase in the HPO amount in Pickering sponges caused a decrease in mechanical properties. As a result, the resulting PVA/CMC/HPO Pickering sponges can be utilized in wound dressing applications owing to their imroved antibacterial activity results.

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“…[9][10][11][12][13][14][15][16] On the one hand, the fibrous structure acts as a topographical cue able to assist cell spreading, guide cell migration, and enhance cell proliferation. [17][18][19][20][21][22][23] On the other hand, the randomly accumulated nanofibers inherently possess high porosity and specific surface area, favorable to vapor exchange and exudate absorption. [24][25][26][27][28][29] In addition, the process suitability of electrospinning allows functional components such as nanoparticles or small-molecule drugs to be uniformly distributed in fibers, [30][31][32] enabling the controlled release of these functional ingredients.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nano‐CaO₂/Polycaprolactone/Gelatin Nanofibers and Their Wound Healing Application through In Situ Supplying H₂O₂

Lin

Huang

Liu

et al. 2022

Macro Materials & Eng

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Skin is highly susceptible to foreign pathogens when damaged. Infections usually lead to serious damage to wounds and hinder wound healing, which results in nonhealing and inflammation of the wounds. Herein, a kind of fibrous membrane incorporated with calcium peroxide nanoparticles (n‐CaO2) is fabricated by electrospinning the polymer blend solution of polycaprolactone and gelatin. The obtained membranes show a randomly distributed nanofibrous structure with n‐CaO2 particles embedded in each fiber. Such a structure endows the membranes with medium hydrophilicity and improves blood clotting in comparison with the commonly used gauze, while the loading of n‐CaO2 achieves the in situ generation and rapid release of hydrogen peroxide (H2O2), enabling FM‐10 to display a robust bacteria inhibition of over 90% elimination to E. coli. The in vitro cytocompatibility experiment on the fibrous membranes demonstrates low cytotoxicity to L929 fibroblasts. The in vivo assessment indicates that the fibrous membranes can distinctly accelerate the wound healing, of which FM‐5 exhibits the highest wound closure rate (>95%) after 14 days. This study provides a versatile approach, simply by varying the loading dosage of n‐CaO2 into fiber matrix, to fulfill different functions to meet the multiple needs of wound care.

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Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings

Cited by 38 publications

References 48 publications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Production and Characterization of Bio‐based Sponges Reinforced with Hypericum perforatum oil (St. John′s Wort Oil) via Pickering Emulsions for Wound Healing Applications

Electrospun Nano‐CaO₂/Polycaprolactone/Gelatin Nanofibers and Their Wound Healing Application through In Situ Supplying H₂O₂

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Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings

Cited by 38 publications

References 48 publications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Chitosan Derivatives as Carriers for Drug Delivery and Biomedical Applications

Production and Characterization of Bio‐based Sponges Reinforced with Hypericum perforatum oil (St. John′s Wort Oil) via Pickering Emulsions for Wound Healing Applications

Electrospun Nano‐CaO2/Polycaprolactone/Gelatin Nanofibers and Their Wound Healing Application through In Situ Supplying H2O2

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Product

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Electrospun Nano‐CaO₂/Polycaprolactone/Gelatin Nanofibers and Their Wound Healing Application through In Situ Supplying H₂O₂