Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease

Zhang, Shangwen; Kang, Li; Hu, Sheng; Hu, Jie; Fù, Yànpíng; Hu, Yan; Yang, Xinzhou

doi:10.1016/j.ijbiomac.2020.11.117

Cited by 82 publications

(43 citation statements)

References 71 publications

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“…H&E staining can reflect the inflammatory injury of colon tissues. 47 The inner layer of colonic mucosa in the control group was composed of intestinal crypts (Figure 8A). The colon tissue of the UC group showed obvious edema, a large number of central granulocyte infiltration, and extensive necrosis of the intestinal crypt.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 99%

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Wang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Although magnolol (Mag), an anti-inflammatory natural compound, has been demonstrated to play protective effects on ulcerative colitis (UC), its application as an alternative therapeutic reagent for UC treatment is still greatly impeded due to its poor stability in the gastrointestinal tract and insufficient accumulation in the inflamed colon lesion. Nano-/microsized drug delivery systems can potentially overcome some challenges regarding the oral administration of phytochemicals, which still confront premature early drug release, degradation of NPs, or the sustained drug release of MPs. In this study, we primarily loaded Mag into the core–shell zein-based nanoparticles with chondroitin sulfate coating (Mag@CS-Zein NPs) with an average size of 142.27 ± 5.11 nm, showing significant macrophage-targeting and enhanced colon epithelial cellular uptake capacity. Then, we embedded Mag@CS-Zein NPs into hydrogel microspheres via an electrospraying technology. The Mag@CS-Zein NPsinMPs presented a uniform-sized sphere with an average size of 164.36 ± 6.29 μm and sustained drug-release profiles. Compared to CS-Zein NPs, the developed CS-Zein NPsinMPs exhibited prolonged colon retention on the inflammatory surface, as seen from ex vivo and in vivo imaging fluorescence adhesion experiments. Based on the advantage of the combination of hybrid nanoparticles-in-microparticles, oral administration of Mag@CS-Zein NPsinMPs significantly alleviated colitis symptoms in DSS-treated mice by regulating the expression levels of proinflammatory cytokines (TNF-α, IL-6, and IL-1β) and anti-inflammatory cytokines (IL-10) and factor accelerated colonic mucosal barrier repair via upregulating the expression of ZO-1 and occludin. This study provides great insights into the oral drug delivery of natural compounds for UC therapy.

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Section: Acs Applied Materials and Interfacesmentioning

confidence: 99%

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Wang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…However, it is worth mentioning that all of our animal models were administered enemas. Although a large number of biological agents are administered by enema, which has the advantages of maintaining the specific distribution of drugs [ 74 ] and facilitating tissue adhesion [ 75 ], it is associated with problems including poor tolerance [ 76 ], embarrassment, and reluctance of patients [ 77 ]. Therefore, we will continue to design and optimize the oral administration of GelNB in future works to broaden its clinical applications.…”

Section: Resultsmentioning

confidence: 99%

GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease

Mao

Pan

Zhang

et al. 2023

Bioactive Materials

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“…176,177 For example, using hyaluronic acid to modify the surface of curcumin nanoparticles can maintain a high level of curcumin in the colon tissue, reduce the proinflammatory factors and reduce the inflammatory response in the colon, which is conducive to the treatment of ulcerative colitis. 178,179 In some inflammatory diseases with superficial disease sites, such as psoriasis and arthritis, nano-emulsion and nanogel can enhance the penetration and accumulation of curcumin in the skin through local administration, which can be used as a direction of preparation research. 57,180 There are many related preparations with varying quality, which will not be described in detail in this paper.…”

Section: Pharmaceutical Strategiesmentioning

confidence: 99%

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Peng¹,

Ao²,

BaoHua³

et al. 2021

DDDT

362

157

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Carboxymethyl chitosan microspheres loaded hyaluronic acid/gelatin hydrogels for controlled drug delivery and the treatment of inflammatory bowel disease

Cited by 82 publications

References 71 publications

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

Oral Core–Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy

GelNB molecular coating as a biophysical barrier to isolate intestinal irritating metabolites and regulate intestinal microbial homeostasis in the treatment of inflammatory bowel disease

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

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