Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy

Tang, Fengxiang; Gao, Fang; Xie, Wei; Li, Sicong; Zheng, Biyuan; Ke, Mei‐Rong; Huang, Jian‐Dong

doi:10.1016/j.carbpol.2020.115949

Cited by 33 publications

(14 citation statements)

References 32 publications

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“…A number of efforts have been devoted to enhance the water solubility of CS derivatives via the reactions with NH 2 and OH functional groups of CS. As result quaternized CS (QCS), 56 carboxymethyl CS, 57 N ‐gluconic acid CS, 58 and CS‐catechol conjugate 59 were obtained, and on reaction with acetic anhydride resulted N‐acetylated CS 60,61 . Table 1 illustrates some of the reports carried out in this field.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Shahzadi

Jamal

Hajivand

et al. 2021

J of Applied Polymer Sci

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In present work, an efficient method for the preparation of water‐soluble chitosan (CS) is reported. It is based on simple synthetic method, which is easy to handle and delivered good water solubility. This article describes the effect of various factors such as the concentration of reactants and the amount of solvents on the reactions' outcome as well as cytocompatibility of the resulting water‐soluble CS derivatives. CS derivatives with different ratios of polyethyleneimine (PEI) (80:20 (CP1), 90:20 (CP2), 95:5 (CP3), 99:1 (CP4), and 99.6:0.4 [CP5]), at optimized conditions (50 g of CS, 1 L of 0.5 M acetic acid solution at 80°C for 24 h) were synthesized. It was noted that the amount of PEI was critical for the cytocompatibility, decreasing the amount of PEI led to increasing the cytocompatibility of the obtained water soluble CS derivatives. To show the biomedical and drug delivery applications of the newly synthesized CS derivative, this was used to prepare membranes by freeze‐drying and was loaded with thyroxine, respectively. The angiogenic potential of the thyroxine loaded membranes was tested in chorio allantoic membrane assay, which showed good level of neovascularization. For wound healing studies full thickness wounds rat model was used and thyroxine loaded hydrogels showed complete wound healing at day 23.

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Section: Resultsmentioning

confidence: 99%

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Shahzadi

Jamal

Hajivand

et al. 2021

J of Applied Polymer Sci

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“…This technique improved the physicochemical and photo-destructive properties of mTHPP for C. albicans through the use of the thermal and penetration properties of the therapeutic region of the electromagnetic spectrum, and consequently reduced the resistance of the colonies, favouring their elimination. Tang et al [25] obtained similar excellent results by combining chitosan with 1-[4-(2-aminoethyl) phenoxy] zinc (II) phthalocyanine (ZnPcN) and quaternising the mixture. This mixture was highly effective for the mitochondria of C. albicans.…”

Section: Niculescu Et Al [15]mentioning

confidence: 90%

New Applications of Photodynamic Therapy in the Management of Candidiasis

Rodríguez-Cerdeira

Martínez‐Herrera

Fabbrocini

et al. 2021

JoF

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The most important aetiological agent of opportunistic mycoses worldwide is Candida spp. These yeasts can cause severe infections in the host, which may be fatal. Isolates of Candida albicans occur with greater frequency and variable resistance patterns. Photodynamic therapy (PDT) has been recognised as an alternative treatment to kill pathogenic microorganisms. PDT utilises a photosensitizer, which is activated at a specific wavelength and oxygen concentration. Their reaction yields reactive oxygen species that kill the infectious microorganism. A systematic review of new applications of PDT in the management of candidiasis was performed. Of the 222 studies selected for in-depth screening, 84 were included in this study. All the studies reported the antifungal effectiveness, toxicity and dosimetry of treatment with antimicrobial PDT (aPDT) with different photosensitizers against Candida spp. The manuscripts that are discussed reveal the breadth of the new applications of aPDT against Candida spp., which are resistant to common antifungals. aPDT has superior performance compared to conventional antifungal therapies. With further studies, aPDT should prove valuable in daily clinical practice.

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“…Therefore, the 49 turned out to better promote photodynamic inactivation of pathogens than the anionic one [243]. Tang et al prepared four conjugates with various contents of pc, and their derivatives with different quaternization degrees to test their antifungal acitivity on C. albicans [244]. To improve the water solubility of the PS and therefore the therapeutic efficacy of PACT, two carboxymethyl chitosans (CMC) of the molecular weight 1.50 kDa and 170 kDa were conjugated with zinc(II) 1-[(aminoeth´2-yl) phen´4-yloxy] phthalocyanine (51, Figure 11) and further quaternized to obtain eight novel conjugates.…”

Section: Porphyrazines and Phthalocyaninesmentioning

confidence: 99%

“…This conjugate exhibited the highest photocytotoxicity with an IC 90 value down to 0.72 µM, whereas further quaternization led to the reduction of the photodynamic antifungal activity. Interestingly, both the unquaternized and quaternized conjugates revealed special affinity to the mitochondria of C. albicans [244]. Ozturk et al studied the antifungal photodynamic potential of five Pc derivatives: 52, 53, 54, 55, and 56 and materials 53-TiO 2 , 54-TiO 2 towards C. albicans [245].…”

Section: Porphyrazines and Phthalocyaninesmentioning

confidence: 99%

Photosensitizers Mediated Photodynamic Inactivation against Fungi

Ziental

Mlynarczyk

Czarczyńska-Goślińska

et al. 2021

Nanomaterials

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Superficial and systemic fungal infections are essential problems for the modern health care system. One of the challenges is the growing resistance of fungi to classic antifungals and the constantly increasing cost of therapy. These factors force the scientific world to intensify the search for alternative and more effective methods of treatment. This paper presents an overview of new fungal inactivation methods using Photodynamic Antimicrobial Chemotherapy (PACT). The results of research on compounds from the groups of phenothiazines, xanthanes, porphyrins, chlorins, porphyrazines, and phthalocyanines are presented. An intensive search for a photosensitizer with excellent properties is currently underway. The formulation based on the existing ones is also developed by combining them with nanoparticles and common antifungal therapy. Numerous studies indicate that fungi do not form any specific defense mechanism against PACT, which deems it a promising therapeutic alternative.

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Carboxymethyl chitosan-zinc(II) phthalocyanine conjugates: Synthesis, characterization and photodynamic antifungal therapy

Cited by 33 publications

References 32 publications

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

New Applications of Photodynamic Therapy in the Management of Candidiasis

Photosensitizers Mediated Photodynamic Inactivation against Fungi

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