Carboxymethylated ?-glucans from mushroom sclerotium of Pleurotus tuber-regium as novel water-soluble anti-tumor agent

Mei, Zhang; Cheung, Peter C.K.; Zhang, Lina; Chiu, Chi-Ming; Ooi, Vincent E.C.

doi:10.1016/j.carbpol.2004.05.008

Cited by 73 publications

(29 citation statements)

References 23 publications

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“…In addition, since both mushrooms contained similar total amino acid contents (Table 2), the RSA of these two oyster mushrooms might have a strong correlation with the phenolic content rather than their amino acid contents, although some amino acids were known to have antioxidant activity 31 . In addition, the antioxidant capacity of these oyster mushroom species could also be contributed to from watersoluble dietary fibre 5,22 (nonstarch polysaccharides). Therefore, a higher antioxidant activity of P. ostreatus than that of P. sajor-caju could contribute to its higher (p < 0.05) dietary fibre content ( Table 1).…”

Section: Radical Scavenging Activity On Dpphmentioning

confidence: 99%

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Chirinang¹,

Intarapichet²

2009

ScienceAsia

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ABSTRACT:The objective of this study was to investigate the amino acid composition and antioxidant properties of two oyster mushroom species, Pleurotus ostreatus and Pleurotus sajor-caju, commercially cultivated in NE Thailand. Proximate composition and dietary fibre of dried mushrooms were determined. Amino acid composition of fresh mushrooms was analysed by HPLC. Water and ethanol extracts were obtained from dried mushrooms and determined for total phenolic contents (TPC) by the Folin-Ciocalteu method, free radical scavenging efficacy by the DPPH method, and reducing power by the ferric reducing-antioxidant power method. Except for protein, proximate compositions of dried mushrooms were significantly different. Similar amino acid profiles in both mushrooms were obtained, with glutamic acid, aspartic acid, and arginine being the three most abundant. Water extracts contained higher TPC and possessed better antioxidant activities than did ethanol extracts for both mushrooms. Overall, P. ostreatus possessed more antioxidant than P. sajor-caju. The EC50 of P. ostreatus and P. sajor-caju water extracts were 11.56 and 13.38 mg/ml, respectively, while those of the ethanol extracts were 31.75 and 58.44 mg/ml, respectively.

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Section: Radical Scavenging Activity On Dpphmentioning

confidence: 99%

“…From a nutritional point of view, mushrooms contain high protein and low fat. In addition, high dietary fibre of mushrooms was reported to function as an antitumour and antiviral agent 4,5 . Moreover, mushrooms are recognized as a good source of amino acids which play an important role in their flavours 6 .…”

Section: Introductionmentioning

confidence: 99%

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Chirinang¹,

Intarapichet²

2009

ScienceAsia

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“…Therefore, mushrooms have been considered as a functional food due to their medicinal properties attributable to β‐glucans. Furthermore, mushroom β‐glucans have been chemically modified by sulfation and carboxymethylation to improve their functional properties 3, 4. Thus, most studies on mushroom β‐glucans have placed primary focus on their physiological and biological activities and suggested their potential use as nutraceuticals or functional materials for pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

(1-3)(1-6)-β-Glucan-enriched materials from Lentinus edodes mushroom as a high-fibre and low-calorie flour substitute for baked foods

Kim

Lee

Bae

et al. 2011

J. Sci. Food Agric.

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“…β-(1,3)-glucan has stronger immunostimulatory activity than β-(1,4)-glucan and β-(1,6)-glucan. Modification of insoluble β-glucan by carboxymethylation or sulfonation or physical methods such as ultrasonic depolymerization and mechanical activation can increase the solubility of β-glucan and thereby enhance its biological activity [97][98][99]. Shi et al [100] mechanically modified Saccharomyces cerevisiae β-glucan to increase the dissolution rate from 11% to 37%, and the β-glucan thus prepared had higher immunological activity.…”

Section: Immunomodulation and Anti-tumor Activitymentioning

confidence: 99%

Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan—A Critical Review

Yuan

Lan

et al. 2019

Molecules

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β-Glucan exhibits many biological activities and functions such as stimulation of the immune system and anti-inflammatory, anti-microbial, anti-infective, anti-viral, anti-tumor, anti-oxidant, anti-coagulant, cholesterol-lowering, radio protective, and wound healing effects. It has a wide variety of uses in pharmaceutical, cosmetic, and chemical industries as well as in food processing units. However, due to its dense triple helix structure, formed by the interaction of polyhydroxy groups in the β-d-glucan molecule, it features poor solubility, which not only constrains its applications, but also inhibits its physiological function in vivo. One aim is to expand the applications for modified β-glucan with potential to prevent disease, various therapeutic purposes and as health-improving ingredients in functional foods and cosmetics. This review introduces the major modification methods required to understand the bioactivity of β-glucan and critically provides a literature survey on the structural features of this molecule and reported biological activity. We also discuss a new method to create novel opportunities to exploit maximally various properties of β-glucan, namely ultrasound-assisted enzymatic modification.

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Carboxymethylated ?-glucans from mushroom sclerotium of Pleurotus tuber-regium as novel water-soluble anti-tumor agent

Cited by 73 publications

References 23 publications

Untitled

Untitled

(1-3)(1-6)-β-Glucan-enriched materials from Lentinus edodes mushroom as a high-fibre and low-calorie flour substitute for baked foods

Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan—A Critical Review

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