Carboxymethylcellulose coated on visceral face of polypropylene mesh prevents adhesion without impairing wound healing in incisional hernia model in rats

Abstract

Adhesions between viscera and mesh may result in intestinal obstruction and fistulae formation. Fewer adhesions with sodium carboxymethylcellulose (SCMC)-coated polypropylene mesh (PM) has been reported, but impaired wound healing was the major concern. We investigated the adhesion-prevention effect of SCMC in different concentrations, as coating only on visceral face of PM and its effects on wound healing. A full-thickness abdominal wall defect was created in 28 rats, which were then divided into three groups. In Group I (control), the defect was repaired with PM only; in Group II and Group III, the defects were repaired with 1% and 1.6% SCMC-coated-PM, respectively. All animals were sacrificed at day 30, and histological evaluation and adhesion scoring were done. Animals in the group in which 1.6% SCMC-coated PM was used developed significantly fewer adhesions compared with other animals (P=0.04). Histological evaluation using a semiquantitative scoring system showed no difference between the groups in fibrosis and inflammation scores (P=0.9 and P=0.3, respectively), and thickness of fibrosis on mesh was also similar (P=0.5). SCMC in 1.6% concentration as coating only on the visceral face of PM reduced the incidence and severity of adhesions without impairing wound healing.

A Novel Hydrogel-Coated Polyester Mesh Prevents Postsurgical Adhesions in a Rat Model

“…However, most of the published work has involved the use of resorbable coating materials, such as cellulose, collagen, and omega-3 fatty acids [30][31][32]. These have been shown to be effective in the short-term, but the protective effects are lost in the long-term as a result of coating breakdown through phagocytosis [33].…”

Investigation into the optimal prosthetic material for wound healing of abdominal wall defects

“…The use of both H-CMC PTFE mesh and PET mesh and were found to be equally effective in incisional hernia repair while decreasing intra-abdominal adhesions. It is also presented that wound healing may be affected with the use of prosthetic materials and anti-adhesive agents (15,16). In order to reduce intra-abdominal adhesions and increase the abdominal tissue support, various prosthetic materials were used.…”

New polymer for intra‐abdominal meshes—PVDF copolymer

“…In several animal studies the advantage of different absorbable barriers could be demonstrated, though no material so far seems to be able to prevent adhesion formation completely. [17][18][19][20] Furthermore the combination of two or more different materials and/or structures changes the textile and biological properties. Certainly, this results in an increase of foreign material and most often lead to a reduction of mesh elasticity.…”