Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent

Abstract

Introduction: In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. Methods: First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique. Results: Performing the various analysis methods including scanning electron microscope (SEM), X-ray diffraction (XRD), EDX, Fourier transform infrared (FTIR) spectroscopy and Zeta potentials on the obtained bio-nanocomposite showed that the new modified GO has been prepared. With using common analysis methods the structure of synthesized materials was determined and confirmed and finally, their antibacterial behavior was examined based on the broth microdilution methods. Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CMC/MOF5/GO has an effective protection against stomach pH. With controlling the TC release in the gastrointestinal tract conditions, the long-time stability of drug dosing was enhanced. Furthermore, antibacterial activity tests showed that the TC-loaded CMC/MOF-5/GO has an antibacterial activity to negatively charge E. coli bacteria in contrast to TC-loaded GO.

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

“…On the other hand, none of the analyzed samples affected the growth of P. aeruginosa, reaching 3.7 ± 1.6 × 10 9 CFU mL −1 under each experimental condition (Figure 7). These results are in line with other studies aimed to unveil the antibacterial potential of CMC-based formulations, such as those containing reduced graphene oxide (rGO) [7] sodium alginate and chitosan [51], a zinc-based metal-organic framework and graphene oxide [52], or sodium alginate and pyrogallic acid [53], all of which in the form of either composite or bio-nanocomposite films. Here, a reasonable explanation for the lack of the antimicrobial activity of the composite films against the P. aeruginosa strain may rely on the higher resistance of Gram-negative bacteria as compared to Gram-positive ones, due to differences in the structure of the cell envelope.…”

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

“…The hollow structure of MOF-5 was synthesized by Lei Z et al [37], the drug-loading rate of the modified nanoparticles was 42.43%, which achieved a more ideal sustained release effect. Tetracycline was encapsulated in the Carboxymethylcellulose/MOF-5/GO bio-nanocomposite, which showed effective protection against stomach pH and enhanced the long-time stability of drug dosing [38]. Therefore, as a new drug carrier, MOF-5 has a high drug loading and excellent release properties.…”

A novel Ag/Ag3PO4‐IRMOF‐1 nanocomposite for antibacterial application in the dark and under visible light irradiation

“…The main optical absorption band is around 290 nm for IRMOF‐1 (Figure a). These optical transitions can be assigned to the interaction between Zn 4 O‐octahedra and organic linker as ligand . For Ag/Ag 3 PO 4 ‐IRMOF‐1 nanocomposite (Figure b) a wide absorption band from 400 to 500 nm was observed, which was attributed to the localized surface plasmon response (LSPR) of the Ag nanoparticles …”

“…These optical transitions can be assigned to the interaction between Zn 4 O-octahedra and organic linker as ligand. [28] For Ag/Ag 3 PO 4 -IRMOF-1 nanocomposite (Figure 4b) a wide absorption band from 400 to 500 nm was observed, which was attributed to the localized surface plasmon response (LSPR) of the Ag nanoparticles. [34] The band-gap energies (Eg) of the samples were obtained from the extrapolated intercept on the abscissa; n = 1 for the direct transition.…”