Carboxypeptidase M in apoptosis, adipogenesis and cancer

Denis, Catherine J.; Deiteren, Kathleen; Hendriks, Dirk; Proost, Paul; Lambeir, Anne‐Marie

doi:10.1016/j.cca.2012.11.012

Cited by 14 publications

(8 citation statements)

References 104 publications

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“…The top one significant SNP for C14:0 is within the carboxypeptidase M ( CPM ) gene. Up-regulation of CPM in macrophages (MAs) is associated with increased lipid uptake [41] and the highest expression of CPM was detected in human adipocyte cell [42] . The SNP associated with C18:1n9c, SFA, UFA and SFA/UFA is 0.77 Mbp away from the oxysterol binding protein-like 8 ( OSBPL8 ) gene which encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors.…”

Section: Discussionmentioning

confidence: 99%

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

et al. 2014

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Detecting genes associated with milk fat composition could provide valuable insights into the complex genetic networks of genes underling variation in fatty acids synthesis and point towards opportunities for changing milk fat composition via selective breeding. In this study, we conducted a genome-wide association study (GWAS) for 22 milk fatty acids in 784 Chinese Holstein cows with the PLINK software. Genotypes were obtained with the Illumina BovineSNP50 Bead chip and a total of 40,604 informative, high-quality single nucleotide polymorphisms (SNPs) were used. Totally, 83 genome-wide significant SNPs and 314 suggestive significant SNPs associated with 18 milk fatty acid traits were detected. Chromosome regions that affect milk fatty acid traits were mainly observed on BTA1, 2, 5, 6, 7, 9, 13, 14, 18, 19, 20, 21, 23, 26 and 27. Of these, 146 SNPs were associated with more than one milk fatty acid trait; most of studied fatty acid traits were significant associated with multiple SNPs, especially C18:0 (105 SNPs), C18 index (93 SNPs), and C14 index (84 SNPs); Several SNPs are close to or within the DGAT1, SCD1 and FASN genes which are well-known to affect milk composition traits of dairy cattle. Combined with the previously reported QTL regions and the biological functions of the genes, 20 novel promising candidates for C10:0, C12:0, C14:0, C14:1, C14 index, C18:0, C18:1n9c, C18 index, SFA, UFA and SFA/UFA were found, which composed of HTR1B, CPM, PRKG1, MINPP1, LIPJ, LIPK, EHHADH, MOGAT1, ECHS1, STAT1, SORBS1, NFKB2, AGPAT3, CHUK, OSBPL8, PRLR, IGF1R, ACSL3, GHR and OXCT1. Our findings provide a groundwork for unraveling the key genes and causal mutations affecting milk fatty acid traits in dairy cattle.

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Section: Discussionmentioning

confidence: 99%

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

et al. 2014

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“…The amino acid transport pathway showed two DEGs overexpressed in the ME group (CPM and ASB11) compared to the PE group. Gene CPM codes for protein carboxypeptidase M, a protein involved in different roles namely hematopoietic cell differentiation, neuronal development with particularly high levels during adipogenesis [69]. Gene ASB11 codes for protein ankyrin repeat and SOCS box containing 11.…”

Section: Major Pathways Affected In Both Feed Restricted Groupsmentioning

confidence: 99%

Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach

et al. 2020

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Background Seasonal weight loss (SWL) is a very important limitation to the production of ruminants in the Mediterranean and Tropical regions. In these areas, long dry seasons lead to poor pastures with low nutritional value. During the dry season, ruminants, particularly those raised in extensive production systems, lose around 30% of their body weight. Seasonal weight loss has important consequences on animal productive performance and health. In this study, RNA sequencing was used to characterize feed restriction effects in dairy goat of 2 breeds with different SWL tolerance: Majorera (tolerant) and Palmera (susceptible). Nine Majorera and ten Palmera goats were randomly distributed in a control and a restricted group: Majorera Control (adequately fed; MC; n = 4), Palmera Control (adequately fed; PC; n = 6), Majorera Restricted (feed restricted; ME; n = 5) and Palmera Restricted (feed restricted; PE; n = 4). On day 22 of the trial, mammary gland biopsies were collected for transcriptomics analysis. Results From these samples, 24,260 unique transcripts were identified. From those, 82 transcripts were differentially expressed between MC and ME, 99 between PC and PE, twelve between both control groups and twenty-nine between both restricted groups. Conclusions Feed restriction affected several biochemical pathways in both breeds such as: carbohydrate and lipid transport; intracellular trafficking, RNA processing and signal transduction. This research also highlights the importance or involvement of the genes in tolerance (ENPP1, S-LZ, MT2A and GPNB) and susceptibility (GPD1, CTPS1, ELOVL6 and NR4A1) to SWL with respectively higher expression in the Majorera restriced group and the Palmera restricted group in comparison to the control groups. In addition, results from the study may be extrapolated to other dairy ruminant species.

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“…3A). CPM is an extracellular peptidase attached to the outer membrane by a glycosyl-phosphatidylinositol (GPI) anchor (15). CPM is highly expressed in the lung, especially on the plasma membrane of alveolar type I cells (16), and the activity of which was much higher in the lung than that found in other tissues (17).…”

Section: Discussionmentioning

confidence: 99%

A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese

Chu¹,

Chen

et al. 2014

Human Molecular Genetics

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Pneumoconiosis is the most serious occupational disease in China and its leading cause is occupational silica exposure. Pneumoconiosis takes several years to develop depending on the exposure level of silica. However, individual variation in the susceptibility to pneumoconiosis has been observed among the subjects with similar exposure. We conducted a genome-wide screening with 710,999 single nucleotide polymorphisms (SNPs) in a cohort of 400 coal workers (202 cases and 198 exposed controls) for pneumoconiosis susceptible loci. Seven promising variants were evaluated in an independent cohort of 568 coal workers (323 cases and 245 exposed controls), followed by a second replication on 463 iron ore workers (167 cases and 296 exposed controls). By pooling all of the genome-wide association studies and replication stages together, we found a genome-wide significant (P < 5.0 × 10(-8)) association for rs73329476 (P = 1.74 × 10(-8), OR = 2.17, 95% CI = 1.66-2.85) and two additional replicated associations for rs4320486 (P < 0.05) and rs117626015 (P < 0.05) with combined P-values of 4.29 × 10(-6) and 5.05 × 10(-6), respectively. In addition, the risk allele T of rs73329476 was significantly associated with lower mRNA expression levels of carboxypeptidase M (CPM) in total cellular RNA from whole blood of 156 healthy individuals (P = 0.0252). The identified pneumoconiosis susceptibility loci may provide new insights into the pathogenesis of pneumoconiosis, and may also have some clinical utility for risk prediction for pneumoconiosis and high-risk population screening for workers with occupational silica exposure.

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Carboxypeptidase M in apoptosis, adipogenesis and cancer

Cited by 14 publications

References 104 publications

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

Genome Wide Association Study Identifies 20 Novel Promising Genes Associated with Milk Fatty Acid Traits in Chinese Holstein

Understanding seasonal weight loss tolerance in dairy goats: a transcriptomics approach

A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese

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