Carboxyterfenadine antacid interaction monitoring by UV spectrophotometry and RP-HPLC techniques

Shehnaz, Hina; Haider, Amir; Arayne, M. Saeed; Sultana, Najma

doi:10.1016/j.arabjc.2013.01.011

Arabian Journal of Chemistry

2014

DOI: 10.1016/j.arabjc.2013.01.011

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Carboxyterfenadine antacid interaction monitoring by UV spectrophotometry and RP-HPLC techniques

Hina Shehnaz

Amir Haider

M. Saeed Arayne

et al.

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Cited by 2 publications

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“…Antacids were found to cause the accelerated excretion of acidic drugs like salicylate and, per contra, might cause the retention of basic drugs like quinidine or amphetamine by elevating the urine pH (6). In addition, antacid fexofenadine interaction has been shown and revealed significant affinity to form charge transfer complexes as determined by both ultraviolet (UV) spectrophotometry and high-performance liquid chromatography (HPLC) (7).…”

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confidence: 99%

Mebeverine HCl and Aluminium/Magnesium Antacid Interactions: A Potential Impact on Electrolyte Replacement Therapy

Aleanizy¹,

Tahir²,

Alqahtani³

et al. 2018

Dissolution Technol.

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When antacids are administered with other drugs, they can alter the absorption, bioavailability, and/or excretion of concomitantly administered drugs. This study aims to characterize the in vitro interaction between different formulations of mebeverine HCl and magnesium trisilicate antacids and salts used for electrolyte-replacement therapy. The dissolution profiles of different formulations of mebeverine alone and in the presence of aluminium/magnesiumcontaining antacids and salts were studied. The release profiles of the drugs and the model and mechanisms of drug release were determined using differential scanning calorimetry and infrared techniques. The loss of mebeverine HCl in each case appeared to be caused by absorption. The calorimetry and infrared results suggest that mebeverine HCl interacts with the antacids and with Movicol. These results should be added to the in vitro drug-drug interaction chart. It is advisable to administer other drugs at least 0.5-1.0 h before antacid ingestion to ensure consistent absorption and effect and to avoid potential interactions.

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mentioning

confidence: 99%

Mebeverine HCl and Aluminium/Magnesium Antacid Interactions: A Potential Impact on Electrolyte Replacement Therapy

Aleanizy¹,

Tahir²,

Alqahtani³

et al. 2018

Dissolution Technol.

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Development of a facile one-pot synthesis method for an ingestible pH sensitive actuator

Keller

Panhuis

2020

MRS Advances

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Edible devices are an emergent technology and in this paper the simplicity and efficacy that poly(acrylic acid)/calcium hydroxide possess in creating a pH sensitive ingestible actuator which responds to acidic environments such as gastric fluid is demonstrated. It was found that poly(acrylic acid)/calcium hydroxide hydrogels exhibit reversible actuation upon submerging in 0.1 M sodium citrate for 2 hours. Our results show that these hydrogels can restore their compressive stress to 0.19 ± 0.06 MPa, swelling ratio to 26 ± 2 and volume to 56% ± 3% of its original volume. This work offers new possibilities for developments in a variety of fields such as drug delivery, 4D printed materials, soft robotics and edible devices.

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Carboxyterfenadine antacid interaction monitoring by UV spectrophotometry and RP-HPLC techniques

Cited by 2 publications

References 15 publications

Mebeverine HCl and Aluminium/Magnesium Antacid Interactions: A Potential Impact on Electrolyte Replacement Therapy

Mebeverine HCl and Aluminium/Magnesium Antacid Interactions: A Potential Impact on Electrolyte Replacement Therapy

Development of a facile one-pot synthesis method for an ingestible pH sensitive actuator

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