This experiment was accompanied to determine the use of yeast and garlic extract mixture in broiler diets on growth performance, nutrient absorption, excreta microbiota, blood profiles, and meat quality. A total of 792 male Ross 308 broilers [1-day-old, body weight, 41 ± 0.5 g, and 5 weeks trial] were randomly allocated. Birds were arbitrarily assigned to one of four nutritive treatments (11 replicates, 18 birds/ replicate). A basal diet (CON) was supplemented with 0.1, 0.2, and 0.3% yeast-garlic mixture (YGM). Body weight gain (BWG) linearly increased during the overall period and tended to increase from day 21 to day 35, while feed intake (FI) showed a tendency to increment during the overall period by YGM inclusion. However, Salmonella counts linearly decreased, but Lactobacillus and E. coli counts remained unaffected. Excreta CO2 emissions were linearly reduced; nevertheless, other noxious gas emissions were not affected. Furthermore, YGM supplementation elicited a tendency for improved lymphocytes and linearly increased IgG. However, feed conversion ratio (FCR), mortality, nutrient utilization and meat quality were not influenced. YGM addition (0.3%) improved broiler growth performance, by decreasing microbiota, and gas emission and increasing blood parameters.