Carcinocythemia: A rare entity becoming more common? A 3‐year, single institution series of seven cases and literature review

Ronen, Shira; Kroft, Steven H.; Olteanu, Horatiu; Hosking, Paul; Harrington, Alexandra M.

doi:10.1111/ijlh.12924

Cited by 10 publications

(17 citation statements)

References 34 publications

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“…A diagnosis of carcinocythemia (carcinoma cell leukemia) 1,2 due to disseminated prostate cancer was rendered. The patient was treated with a combination of radiation therapy, systemic anti‐androgen therapy, and had remarkable improvement in his clinical symptoms, anemia, and pancytopenia.…”

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confidence: 99%

Carcinocythemia—Cancer cell leukemia

Jain

Wang

2020

American J Hematol

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A 60-year-old man presented with a one-week history of fatigue and bilateral lower extremity pain. Physical examination was normal. Work up revealed anemia (hemoglobin 8.4 g/dL), WBC 4.2 K/uL, platelets 55 K/uL, MCV 83 fL and PSA levels 1872 ng/L. Peripheral blood smear showed normocytic, normochromic anemia and thrombocytopenia. Atypical cells with irregular nuclear contour were also noted (A) and blasts or dysplasia was absent. MRI spine showed severe lumbar spinal canal narrowing and compression of the cauda equina nerve roots. CT scan showed pelvic/retroperitoneal lymphadenopathy and pleural effusions. Tc 99 m-labeled bone scan confirmed diffuse bone metastases. Bone marrow (BM) touch preparation demonstrated clusters of atypical cells with hyperchromatic nuclei (B). BM was replaced by atypical cells (C). The large atypical cells were positive for pancytokeratin and PSA (D-E). Immunophenotyping did not show any aberrant B or T cells.A diagnosis of carcinocythemia (carcinoma cell leukemia) 1,2 due to disseminated prostate cancer was rendered. The patient was treated with a combination of radiation therapy, systemic anti-androgen therapy, and had remarkable improvement in his clinical symptoms, anemia, and pancytopenia. Dissemination of prostate cancer in

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Carcinocythemia—Cancer cell leukemia

Jain

Wang

2020

American J Hematol

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“…In 1976, the term carcinocythaemia was proposed for the finding of carcinoma cells circulating in peripheral blood (Carey et al) 1 . Since then, a small number of patients suffering from different types of solid malignancies showing carcinoma cells circulating in blood have been described associated with advanced stages of the disease 2,3 . Carcinocythaemia differs from tumour cells circulating in blood, which can only be detected after enrichment and isolation by immunophenotypic and genotypic analyses 3 .…”

Section: Hospitalization Day Neutrophils Nv: 20‐70 × 109/l Rbcs mentioning

confidence: 99%

“…1 Since then, a small number of patients suffering from different types of solid malignancies showing carcinoma cells circulating in blood have been described associated with advanced stages of the disease. 2,3 Carcinocythaemia differs from tumour cells circulating in blood, which can only be detected after enrichment and isolation by immunophenotypic and genotypic analyses. 3 Recently, we reported carcinocythaemia finding in a patient diagnosed with breast carcinoma.…”

Section: Signet Ring Cell Carcinocythaemia In An Advanced Gastric Carcinomamentioning

confidence: 99%

“…7 The term of carcinocythaemia, also known as carcinoma cell leukaemia, was originally described as the presence of circulating carcinomatous cells, which can mimic leukaemia. 1 The small number of cases of carcinocythaemia (about 39) reported previously [1][2][3][4] includes metastatic solid malignancies such as small cell lung cancer, rhabdomyosarcoma, colonic signet ring cell carcinoma and cases of breast carcinoma. To the best of our knowledge, carcinocythaemia in signet ring cell gastric carcinoma has not been previously reported.…”

Section: Signet Ring Cell Carcinocythaemia In An Advanced Gastric Carcinomamentioning

confidence: 99%

“…FM Pérez reviewed and validated the stainings. A. Merino identified the patient, designed the study and reviewed the paper.Natalia Rakislova1,2…”

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