Carcinoembryonales Antigen (CEA) und CEA-like Aktivit�t in Ascites und Pleuraerg�ssen

Eimermacher, Hartmut; W, Tinnefeld; Preßler, H.; Schuster, Paul; Hk, Beyer

doi:10.1007/bf01491136

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…Among these, there are total protein, glucose, serum-ascites albumin gradient (S-AA), and lactate dehydrogenase (LDH), leucine amino peptidase (LAP), and gamma-glutamyl-transpeptidase (GGT) enzyme activities, as well as lipid analyses [1][2][3][4][5][6][7]. Fibronectin (FN), a glycoprotein, has been determined in only a few studies to distinguish ascites of malignant origin from ascites caused by chronic liver disease.…”

mentioning

confidence: 99%

Significance of fibronectin in cirrhotic and malignant ascites.

Salmayenli

Sıvas

1990

J. Clin. Biochem. Nutr.

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mentioning

confidence: 99%

Significance of fibronectin in cirrhotic and malignant ascites.

Salmayenli

Sıvas

1990

J. Clin. Biochem. Nutr.

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Carcinoembryonic antigen in pleural effusions. Diagnostic value in malignant mesothelioma

Faravelli

D'Amore

Nosenzo

et al. 1984

Cancer

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The usefulness of the determination of carcinoembryonic antigen (CEA) in pleural effusion was assessed as an aid to the diagnosis of malignant mesothelioma. The concentration of CEA was determined by radioimmunoassay (RIA) in pleural fluid of 213 adult patients, of which 140 had malignant pleural disease and 73 had nonmalignant pleural disease. Pleural fluid CEA (PF CEA) was lower than 12 ng/ml in all 15 mesotheliomas. The statistical probability of a mesothelioma associated with PF CEA greater than 15 ng/ml was found to be zero. The CEA assay in pleural effusion proved to be a valuable adjunct to other diagnostic procedures in differentiating the malignant mesothelioma from metastatic serosal spread. Cancer 53:1194‐1197, 1984.

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Ascitic fluid analysis for the differentiation of malignancy-related and nonmalignant ascites. Proposal of a diagnostic sequence

Gerbes¹,

Jüngst²,

Xie³

et al. 1991

Cancer

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The authors tried to differentiate malignancy-related from nonmalignant ascites with a sequence of sensitive followed by specific ascitic-fluid parameters. There were four results of this study. First, of nine parameters investigated in a first series of 48 patients, 28 with nonmalignant and 20 with malignancy-related ascites, ascitic-fluid cholesterol and fibronectin yielded the best negative predictive value of 92% each, Carcinoembryonic antigen (CEA) and cytologic examination both showed a positive predictive value of 100%. Second, combining cytologic examination (sensitivity, 70%) and CEA determination (sensitivity, 45%) increased the sensitivity to 80%. Third, cytologic findings were negative in all ascitic-fluid samples with a cholesterol concentration below the cutoff value of 45 mg/100 ml. Fourth, based on the results of the first series of 48 patients, the diagnostic sequence with cholesterol as a sensitive parameter, followed by the combination of cytologic examination and CEA determination as specific parameters, was tested in a second series of 71 patients, 37 with nonmalignant and 34 with malignancy-related ascites. Again cytologic examination was negative in all samples with cholesterol levels below 45 mg/100 ml. In the total of 119 patients, this diagnostic sequence did not identify 9% of patients with malignancy-related ascites, and 82% of samples classified as malignancy related by cholesterol levels above 45 mg/100 ml were confirmed by positive cytologic examination and/or CEA level above 2.5 ng/ml. Thus, a diagnostic sequence with ascitic-fluid cholesterol determination, followed by cytologic examination and CEA determination, in samples with cholesterol levels above 45 mg/100 ml should permit a cost-efficient routine differentiation of malignancy-related from nonmalignant ascites. Cancer 68: 1808-1814,1991. HE DIFFERENTIATION between malignancy-related T (MRA) and nonmalignant ascites (NMA) is important for further diagnostic and therapeutic procedures. Several components of ascitic fluid were tested for their

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Carcinoembryonales Antigen (CEA) und CEA-like Aktivit�t in Ascites und Pleuraerg�ssen

Cited by 9 publications

References 14 publications

Significance of fibronectin in cirrhotic and malignant ascites.

Significance of fibronectin in cirrhotic and malignant ascites.

Carcinoembryonic antigen in pleural effusions. Diagnostic value in malignant mesothelioma

Ascitic fluid analysis for the differentiation of malignancy-related and nonmalignant ascites. Proposal of a diagnostic sequence

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