Carcinoembryonic antigen as a monitor of recurrent breast cancer

Lee, Yeu‐Tsu N.

doi:10.1002/jso.2930200209

Cited by 13 publications

(2 citation statements)

References 26 publications

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“…Among patients with known recurrent disease, only 48% had elevated CEA values, and among those known to be free of disease for six months or more after the test, t0% also had elevated CEAs (63). There are conflicting results in the literature regarding the value of using CEA test to monitor relapse after mastectomy.…”

Section: Sequence Of Relapses and Prognosismentioning

confidence: 99%

Patterns of metastasis and natural courses of breast carcinoma

Lee

1985

Cancer Metast Rev

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Breast carcinoma is known to metastatize to all organs. In order to understand the patterns of spread and natural courses, this review summarizes detailed studies of patients with various stages of the disease. After treatment of early breast carcinoma (stage I, II, and some III), the recurrent lesion can be classified as local, regional, distant, or combinations thereof. The sites of dissemination of patients presenting with stage IV disease and of those who had autopsy after diagnosis of breast cancer are presented for comparison. Clinicopathological factors that influence the relative incidence, specific site, subsequent event, and prognosis of recurrent and metastatic breast cancers are discussed.

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Section: Sequence Of Relapses and Prognosismentioning

confidence: 99%

Patterns of metastasis and natural courses of breast carcinoma

Lee

1985

Cancer Metast Rev

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“…5], However, the percentages of early elevated levels reported in the studies vary between 20% [6,7] and 60-80% [8,9], depending in part on the different relapse locations involved. However, seri al CEA levels are of clinical utility and persistently ele vated levels (particularly over lOng/ml) are strongly in dicative of relapse [10].…”

Section: Introductionmentioning

confidence: 98%

CA15.3, CEA and TPA Tumor Markers in the Early Diagnosis of Breast Cancer Relapse

Vizcarra

Lluch²,

Cibrián³

et al. 1994

Oncology

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To evaluate the utility of CA 15.3 in detecting breast cancer relapse before clinical evidence of metastatic disease, serial determinations of CA 15.3 serum levels were made in 444 disease-free patients after surgery, during 36 months of follow-up. The results were compared with carcinoembryonic antigen (CEA) and tissue polypeptide antigen (TPA). The study found CA 15.3 to be more sensitive as an early indicator of relapse than CEA or TPA; moreover, simultaneous determination of the other markers offers no information additional to that obtained by CA 15.3 alone.

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Biological markers for breast carcinoma

Waalkes¹,

Enterline

Shaper

et al. 1984

Cancer

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During the last decade, there has been an intense search for biological markers for breast carcinoma. Many different types of materials have been found that may be elevated in the body fluids of patients with this disease. However, no markers specific for breast cancer have been discovered and those currently available lack the sensitivity and specificity for early detection of the disease or for determining when the tumor burden is low. Problems may also occur in the interpretation of marker data due to apparent biological variations in synthesis or secretion. Plasma carcinoembryonic antigen (CEA), elevated in 60%‐70% of patients with metastases, has had the most extensive evaluation. For the latter patients with increased plasma CEA, the levels in general are proportional to tumor burden. Changes in level with therapy correlate with measurable clinical parameters of response or progression in the majority of these patients. Specific patterns of serial CEA measurements after mastectomy may be helpful for predicting those patients most likely to develop recurrent disease. More recent attention has focused on trials of combinations of markers and on tissue measurement. The search for a specific marker for breast cancer using monoclonal antibody techniques is a promising area of considerable research interest.

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Carcinoembryonic antigen as a monitor of recurrent breast cancer

Cited by 13 publications

References 26 publications

Patterns of metastasis and natural courses of breast carcinoma

Patterns of metastasis and natural courses of breast carcinoma

CA15.3, CEA and TPA Tumor Markers in the Early Diagnosis of Breast Cancer Relapse

Biological markers for breast carcinoma

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