2007
DOI: 10.1016/j.jbiotec.2006.08.007
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Carcinoembryonic antigen (CEA) mimicry by an anti-idiotypic scFv isolated from anti-Id 6.C4 hybridoma

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Cited by 15 publications
(8 citation statements)
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“…The remarkable ability of anti‐Id antibodies to mimic the original antigen has been shown in several models. ( 15–28 ) Anti‐Id antibodies might induce a specific immune response against tumor‐associated antigens, such as the carcinoembryonic antigen ( 29,51 ) and the human high molecular weight melanoma‐associated antigen ( 52 ) among others. ( 22–27 ) In addition, two anti‐idiotype R24 antibodies (BEC2 and BEC3) have been previously isolated.…”
Section: Discussionmentioning
confidence: 99%
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“…The remarkable ability of anti‐Id antibodies to mimic the original antigen has been shown in several models. ( 15–28 ) Anti‐Id antibodies might induce a specific immune response against tumor‐associated antigens, such as the carcinoembryonic antigen ( 29,51 ) and the human high molecular weight melanoma‐associated antigen ( 52 ) among others. ( 22–27 ) In addition, two anti‐idiotype R24 antibodies (BEC2 and BEC3) have been previously isolated.…”
Section: Discussionmentioning
confidence: 99%
“…We have also previously described an anti‐Id monoclonal antibody that was able to mimic glycoprotein carcinoembryonic antigen (CEA) and elicit an anti‐anti‐Id mAb that recognized the antigen in vitro and in vivo . ( 28–30 ) In the present study, we immunized BALB/c mice with the mAb R24 with the expectation of obtaining anti‐Id antibodies bearing the internal image of GD3. Animals were shown to produce anti‐Id and anti‐anti‐Id antibodies of IgM and IgG classes.…”
mentioning
confidence: 99%
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“…In those trials, most patients developed both anti-anti-Id polyclonal antibodies and cellular immune responses specific for both the anti-Id used for treatment and the actual CEA expressed by the tumor of the patients. In this respect, it is not clear whether the use of an anti-Id single-chain fragment variable, rather than the whole Ig (Pignatari et al, 2006), or that of CpG motifs as immune adjuvants might prove in any way advantageous. Similarly, further clinical trials are warranted to assess the therapeutic potential of anti-Id mAbs mimicking CD55, which have also recently entered the clinical arena with intriguing immunologic results (Ullenhag et al, 2006).…”
Section: Colorectal Cancermentioning
confidence: 99%
“…Also, scFv has been employed in several therapeutic models [20]–[23]. Dendritic cells (DCs) strongly upregulate the expression of costimulatory molecules and production of cytokines, and thus, they constitute the most potent antigen presenting cells (APCs), which are capable of stimulating naïve antigen-specific T cells and inducing a primary immune reaction.…”
Section: Introductionmentioning
confidence: 99%