Carcinoembryonic antigen in intraepithelial neoplasia of the uterine cervix

Nagell, J.R. van; Meeker, William R.; Parker, Joseph C.; Kashmiri, Rafiah; McCollum, Viola

doi:10.1016/0002-9378(76)90473-7

Cited by 13 publications

(2 citation statements)

References 17 publications

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“…Raised serum CEA levels have been shown to be associated with a variety of malignant gynaecological tumours (van Nagell et al 1975, Seppala, Pihko & Ruoslahti 1975, Rutanen et nl. 1978 and in specific studies of squamous carcinomas of the female genital tract, raised plasma levels have been found with both invasive (Kjorstad & Orjaseter 1978, Ito, Kurihara & Nishimura 1978 and pre-invasive (van Nagell et al 1976, Di Saia et al 1977 carcinoma.…”

Section: Discussionmentioning

confidence: 96%

“…However, in in-situ carcinoma of cervix, although raised plasma CEA levels have been found (Di Saia 1974, van Nagell et al 1976, Di Saia et ul. 1977, immunohistochemical methods either failed to demonstrate CEA in cervical pre-malignant lesions (Goldenberg et al 1976) or demonstrated CEA in a lower frequency (Lindgren,Wahlstroni & Seppala I979), than in our series.…”

Section: Discussionmentioning

confidence: 99%

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The immunohistological demonstration of carcinoembryonic antigen in intra‐epithelial and invasive squamous carcinoma of the cervix

McDicken

Rainey

1983

Histopathology

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Using the sensitive peroxidase, anti-peroxidase immunohistological technique, carcinoembryonic antigen (CEA) was studied in formalin-fixed, paraffin-embedded cervical specimens from 225 patients. CEA was demonstrated in 33% of moderate dysplasia, 78.5% of severe dysplasia, 79% of in-situ carcinoma and 78% of invasive carcinoma. CEA was not demonstrated in normal squamous epithelium, squamous metaplasia, reserve cell hyperplasia nor in mild dysplasia.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The immunohistological demonstration of carcinoembryonic antigen in intra‐epithelial and invasive squamous carcinoma of the cervix

McDicken

Rainey

1983

Histopathology

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The use and abuse of cea test in clinical practice

Meeker

1978

Cancer

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Charts of 437 patients having plasma carcinoembryonic antigen determinations during the period January 1, 1976 through April 30, 1976 were reviewed to determine whether CEA results led to clinical decisions altering management patterns. Data analysis disclosed that CEA test results did not result in any change in management in 167 patients with non‐neoplastic disease. Most had single determinations. In 270 patients with neoplastic disease, CEA results led to changes in management in one patient with lung cancer and two patients with colon cancer, which may have altered prognosis. In a fourth patient, CEA results led to discovery of unresectable pancreatic cancer at laparotomy. Cost benefit analysis indicated a CEA test cost of $5,047 0.50 per patient benefitted in 299 patients eligible for analysis. We conclude that maximal benefit to the patient results from serial CEA test use in follow‐up of colon cancer patients after curative therapy.

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Influence of specialty affiliation on physicians' pattern of use of CEA test

Meeker

1978

Cancer

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several different patterns of CEA test use which appeared to be related to the specialty affiliations of attending physicians. A majority of patients having nonneoplastic disease diagnoses (69%) were from general medicine and medical specialty services. Also, most patients with benign disease diagnoses (95%) had single CEA determinations which were performed for diagnosis. No change in patient management resulted from CEA test use in patients with nonneoplastic disease. In contrast, a majority (82%) of patients having neoplastic disease diagnoses were on the gynecologic and general surgical services and two-thirds of patients with neoplastic disease diagnoses had multiple determinations. Since patients with neoplastic disease from the gynecologic service were included in ongoing studies conducted by that service in which clinical decisions were not made on the basis of CEA test results, they were excluded from further analysis. In the remaining patients with malignancy, the CEA test was mostly used for purposes of follow-up. In this group, three patients from the surgery services and one from the medicine services had alterations in patient management resulting from CEA test use. Prognosis was altered as a result of CEA test results leading to diagnosis and therapy in one patient with lung cancer and re-exploration of two patients during follow-up of previously resected colon cancer. Maximal cost effectiveness of CEA test appeared to result from the pattern of use most commonly employed by the general surgical services, i.e., follow-up of patients following curative resection of colon cancer.

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Carcinoembryonic antigen in intraepithelial neoplasia of the uterine cervix

Cited by 13 publications

References 17 publications

The immunohistological demonstration of carcinoembryonic antigen in intra‐epithelial and invasive squamous carcinoma of the cervix

The immunohistological demonstration of carcinoembryonic antigen in intra‐epithelial and invasive squamous carcinoma of the cervix

The use and abuse of cea test in clinical practice

Influence of specialty affiliation on physicians' pattern of use of CEA test

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