Carcinogen Classification Systems: Similarities and Differences

T25: A Simplified Carcinogenic Potency Index: Description of the System and Study of Correlations between Carcinogenic Potency and Species/Site Specificity and Mutagenicity

“…In a recent survey of classficiation systems on carcinogens in OECD countries (Sanner et al 1996) only 2 (Norway and Sweden) out of 21 countries had incorporated potency considerations in their classification schemes. The present T25 carcinogenic potency index was developed as a proposal of inclusion of potency considerations in setting specific concentration limits for carcinogens according to the European Union (EU) regulation (European Union 1967& 1988.…”

“…It is therefore somewhat surprising that most current regulatory classification schemes do not take carcinogenic potency into account (Sanner et al 1996). On the other hand, both classification for acute toxicity as well as corrosivityhrritation incorporate potency considerations.…”

“…Carcinogenic potency, as characterized by the magnitude with respect to dose of the carcinogenic activity of a chemical, varies more than 10 millionfold between individual carcinogens . It is therefore somewhat surprising that most current regulatory classification schemes do not take carcinogenic potency into account (Sanner et al 1996). On the other hand, both classification for acute toxicity as well as corrosivityhrritation incorporate potency considerations.…”

Defining lethal chemicals in industrial facilities

“…In Norway and Sweden, the high potency classification is based on dose-response relationships as well as on mechanistic considerations. 23 This potency assessment can be an aid in identifying the carcinogens that should be included in the 'lethal service chemicals'. The existing classification schemes do not differ in the mechanics of carcinogenesis.…”

The selective cleanup of complex matrices and simultaneous separation of benzo[a]pyrene by solid-phase extraction with MgO microspheres as sorbents

“…Polycyclic aromatic hydrocarbons (PAHs) have been classified as cancer-causing agents by the International Agency for Research on Cancer (IARC) and the United States Environmental Protection Agency (US EPA), on the basis of evidences derived from studies in humans, experimental animals and other relevant data [1][2][3]. According to the carcinogenicity classification of 16 PAHs by the US EPA, benzo [a]pyrene (BaP) is the most dangerous chemical among them.…”