Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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“…( Abe et al 2012 ; Doi et al 2004 ; Kokoshima et al 2014 ; Sakai et al 2000 ; Shimoi et al 2001 ; Takaoka et al 1994 ; Weber et al 2009 )…”

Section: Thyroid Glandunclassified

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

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“…Although the thyroids showing the vacuolar change with normal growth reported to be more sensitive to carcinogens than normal thyroids (Abe et al 2012), there was no indication of increased preneoplastic and neoplastic lesions in oncogenicity studies (Weber et al 2009). These facts also support the relationship between occurrence of these lesions in our D rats and TSH stimulation.…”

Section: Discussionmentioning

confidence: 99%

Proliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats

et al. 2013

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We observed spontaneous dwarfism among Wistar Hannover GALAS rats, caused by primary hypothyroidism. The dwarf (D) rats showed markedly high serum thyroid-stimulating hormone (TSH) values. In this study, we investigated the incidence and histopathological characteristics of the proliferative lesions of the thyroid follicular cells in our D rats. Gross enlargement of thyroid and histological vacuolar change of the thyroid follicular cells with age-related progression suggesting diffuse hypertrophy/hyperplasia were seen in all the D rats. In addition, focal proliferative lesionsnamely hyperplasias, activated hyperplasias, adenomas, and adenocarcinomas-were seen in D rats aged over 50 weeks. Taken together, these results suggested that the sustained stimulation of elevated levels of serum TSH caused and enhanced diffuse hypertrophy of thyroid follicular cells and subsequent development of focal proliferative lesions.

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“…Heterozygous rats have thyroid dysplasia but are euthyroid (Weber et al, 2009). It has been reported that there was no increase in follicular cell hyperplasia or neoplasia, but the homozygous rats may be more sensitive to carcinogens (Abe et al 2012). Dwarf or stunted rats are hypothyroid with increased circulating thyroid stimulating hormone (TSH) (Doi et al 2004).…”

Section: Nomenclature Challenges From the Endocrine Inhand Owgmentioning

confidence: 99%

Proceedings of the 2014 National Toxicology Program Satellite Symposium

et al. 2014

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The 2014 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in Washington DC, in advance of the Society of Toxicologic Pathology’s 33rd annual meeting. The goal of this annual NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers’ presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included a pulmonary mucinous adenocarcinoma in a male B6C3F1 mouse; plexiform vasculopathy in Wistar Han rats; staging of the estrous cycle in rats and mice; peri-islet fibrosis, hemorrhage, lobular atrophy and inflammation in male Sprague Dawley rats; retinal dysplasia in Wistar Han rats and B6C3F1 mice; multicentric lymphoma with intravascular microemboli and tumor lysis syndrome, and two cases of myopathy and vascular anomaly in Tg.rasH2 mice; benign thymomas in Wistar Han rats; angiomatous lesions in the mesenteric lymph nodes of Wistar Han rats; an unusual foveal lesion in a cynomolgous monkey; and finally a series of nomenclatures challenges from the endocrine International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) organ working group (OWG).

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Carcinogen-induced Thyroid Proliferative Lesions in Wistar Hannover GALAS Rats with Thyroid Dysplasia

Cited by 4 publications

References 13 publications

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Proliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats

Proceedings of the 2014 National Toxicology Program Satellite Symposium

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