Carcinogenic activity of benzo[a]pyrene in a 2 year oral study in Wistar rats

Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential

“…Benzo[a]pyrene, a widespread environmental carcinogen notably found in cigarette smoke, exhaust fumes and grilled meat, induces cancer in multiple organs, including liver (Wester et al, 2012), and has recently been classified as a human carcinogen from group 1 by the International Agency for Research on Cancer (IARC, 2010). Although this xenobiotic has been shown to affect the different steps of tumor development (i.e.…”

Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment

“…In mg BaP/kg-bw-day. c Forestomach tumour was the most sensitive endpoint in [117], but was excluded from this analysis as forestomach data from [116] yielded about 2-fold lower values for BMDL 10 than [117]. d Significantly different from controls (p < 0.05 by ANOVA), as tested in [116]; the information on statistical significance was unavailable from [117].…”

“…As a result, the data from only one study [12] were used for BMD modelling (Table 11). For cancer endpoints, the data were taken from [116] and [117]. The former were used previously in BaP guideline development [10,118].…”

Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice

“…Moreover, B[a]P is well documented as a potent mutagenic, carcinogenic and pro-oxidative agent in experimental animals (Wijnhoven et al, 2000;Wester et al, 2012). It is bio-transformed to reactive metabolites such as B[a]P-7,8-epoxide, BaP-7,8-dihydrodiol 9,10-epoxide and quinones which subsequently damage the DNA and generate excessive reactive oxygen (Archibong et al, 2008).…”