Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats

Lynch, Dennis W.; Lewis, Trent R.; Moorman, William J.; Burg, JeAnne R.; Groth, David H.; Khan, Amir; Ackerman, Larry J.; Cockrell, Beverly Y.

doi:10.1016/0041-008x(84)90030-9

Cited by 206 publications

(59 citation statements)

References 15 publications

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“…These types of tumour did not occur in the control group. In addition, adrenal phaeochromocytomas were significantly increased, although not in a concentration-dependent manner (8/78, 25/78, 22/80), while peritoneal mesotheliomas were not significantly increased (3/78, 8/78, 9/78) (Lynch et al 1984).…”

Section: Long-term Studiesmentioning

confidence: 92%

1,2‐Epoxypropane [MAK Value Documentation, 2013]

2015

The MAK‐Collection for Occupational Health and Safety

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The article contains sections titled: Toxic Effects and Mode of Action Mechanism of Action Toxicokinetics and Metabolism Absorption, distribution, elimination Metabolism Effects in Humans Single exposures Repeated exposure Local effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Animal experiments and in vitro studies Acute toxicity Subacute, subchronic and chronic toxicity Local effects on skin and mucous membranes Allergenic effects Reproductive and developmental toxicity Genotoxicity Carcinogenicity Manifesto (MAK value/classification)

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Section: Long-term Studiesmentioning

confidence: 92%

1,2‐Epoxypropane [MAK Value Documentation, 2013]

2015

The MAK‐Collection for Occupational Health and Safety

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“…Si bien a nivel experimental diversas publicaciones atribuyen algunos tipos de neoplasia al óxido de etileno 26,28 , los estudios epidemiológicos observacionales realizados en poblaciones humanas proporcionan resultados muy contradictorios. Así Hogsted y col.…”

Section: Efectos Mutagénicos Cancerígenos Teratogénicos Y De La Fununclassified

Aspectos toxicológicos de la exposición al óxido de etileno

Marín

Gallén

1987

Rev. Saúde Pública

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PRAT-MARÍN, A. & SANZ-GALLÉN, P. Aspectos toxicológicos de la exposición al óxido de etileno. Rev. Saúde públ., S. Paulo, 21:523-8, 1987. RESUMEN:En este trabajo se revisan los principales riesgos de la utilización del óxido de etileno como agente esterilizante del material médico-quirúrgico. Resaltando los efectos tóxicos, mutagénicos, teratogénicos y cancerígenos como los más importantes, enfatizando en la necesidad de adoptar medidas de prevención para controlar dichos riesgos. DESCRIPTORES:Óxido de etileno, toxicidad. Esterilización. Riesgo.* Departamento de Salud Pública y Legislación Sanitaria da Universidad de Barcelona -Avda. Diagonal, s/n. -08028 -Barcelona, España. INTRODUCCIÓNEl empleo de diferentes substancias con una finalidad industrial o sanitaria, puede comportar riesgos de diversa naturaleza que interesa conocer adecuadamente. El óxido de etileno es un gas que, a temperatura y presión normales, tiene una densidad superior a la del aire y es soluble en agua. Por su estructura química (Figura) pertenece al grupo de los epoxy compuestos. Este oxileno o enlace epoxy es extremadamente reactivo con todo tipo de material que entra en contacto con él. El óxido de etileno actúa combinándose con los grupos carboxilo, amino, sulfhidrilo e hidroxilo de las proteínas bacterianas. Para evitar hipoté-ticas inflamaciones se utiliza generalmente mezclado con gases inertes; cuando se le comparan sus propiedades esterilizantes con las de otros agentes químicos (óxido de propileno, formalina, glicoles, etilenimina, halóge-nos, glutaraldehido, etc.), es el mas efectivo y el menos peligroso de todos ellos. Actualmente es una de las 25 substancias químicas mas utilizadas mundialmente 37,43 .Sin embargo, en los últimos años se ha cuestionado su uso, como resultado de diversas investigaciones, en las que, se le imputan unos posibles efectos mutagénicos, teratogénicos y cancerígenos 13,20,43 .Debido a su amplia utilización en el medio hospitalario como agente esterilizante del material médico-quirúrgico (Tabla 1), efectuamos una revisión y puesta al día de esta incipiente temática.

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“…The increased mortality was possibly due to a chemically induced destruction of the mucociliary apparatus in the upper airway, which may have contributed to fatal lower respiratory infections. A chronic inhalation bioassay of propylene oxide revealed dose-dependent nasal epithelial proliferative lesions and two nasal adenomas in rats with intercurrent MRM (23). The significance of the proliferative nasal lesions, which appeared to be treatment related, was difficult to interpret, since their development may have been influenced by intercurrent infectious inflammatory disease.…”

Section: The Pathogenesis Of Natural and Experimentalmentioning

confidence: 99%

Infectious Diseases of the Upper Respiratory Tract: Implications for Toxicology Studies

Everitt¹,

Richter²

1990

Environmental Health Perspectives

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The consequences of adventitious infectious agents upon the interpretation of toxicology studies performed in rats and mice are incompletely understood. Several prevalent murine pathogens cause alterations of the respiratory system that can confuse the assessment of chemically induced airway ixjury. In some instances the pathogenesis ofinfection with these agents has been relatively well studied in the lower respiratory tract. However, there are few well-controlled studies that have examined the upper respiratory region, which result in interpretive problems for toxicologic pathologists. The conduct and interpretation ofboth short-term and chronic rodent bioassays can be compromised by both the clinical and subclinical manifestations of infectious diseases. This paper reviews several important infectious diseases of the upper airway of rats and mice and discusses the potential influence of these conditions on the results of toxicology studies.

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Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats

Cited by 206 publications

References 15 publications

1,2‐Epoxypropane [MAK Value Documentation, 2013]

1,2‐Epoxypropane [MAK Value Documentation, 2013]

Aspectos toxicológicos de la exposición al óxido de etileno

Infectious Diseases of the Upper Respiratory Tract: Implications for Toxicology Studies

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