Carcinogenic potential of formaldehyde in occupational settings: a critical assessment and possible impact on occupational exposure levels

Duhayon, Sophie; Hoet, Peter; Maele-Fabry, Geneviève Van; Lison, Dominique

doi:10.1007/s00420-007-0241-9

Cited by 39 publications

(32 citation statements)

References 32 publications

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“…Formaldehyde is considered to be a carcinogenic compound in humans, even if the evidence of an association between occupational formaldehyde exposure and nasopharyngeal cancer is still under debate [9,10]. On the basis of a thorough analysis of existing epidemiological studies and the plausibility of biological mechanisms resulting from experimental studies, formaldehyde has been considered as a carcinogenic compound in humans [6].…”

Section: Health Effectsmentioning

confidence: 99%

Development of French Indoor Air Quality Guidelines

Mandin

Bonvallot

Kirchner

et al. 2009

CLEAN Soil Air Water

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Indoor air quality guidelines (IAQGs) provide safe levels of indoor pollutant concentrations below which adverse health effects are not expected to occur in the general population, including susceptible subgroups. The French Agency for Environmental and Occupational Health Safety and the French Scientific and Technical Centre for Building have been leading a national working group to develop IAQGs based on health criteria. Firstly, a list of substances of concern was established for which IAQGs should be provided, and priority substances were identified. For each substance, toxicological and epidemiological data was reported and discussed. A critical effect and, if possible, a mode of action explaining the toxicity was described. Existing health based IAQGs already established and recommended by international groups or by some countries are collected, together with available toxicity reference values from the US Environmental Protection Agency, the Agency for Toxic Substances and Disease Registry, the California Office of Environmental Health Hazard Assessment, Health Canada and the Dutch Agency for Environmental Health. After an in‐depth analysis of these values, IAQGs are proposed. The production of an IAQG for a threshold pollutant (formaldehyde) and for a non‐threshold carcinogenic compound (benzene) are presented as examples.

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Section: Health Effectsmentioning

confidence: 99%

Development of French Indoor Air Quality Guidelines

Mandin

Bonvallot

Kirchner

et al. 2009

CLEAN Soil Air Water

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“…Further more, there are cohort and case-control studies investigating the association between occupational exposure to formaldehyde and Nasopharyngeal Cancer (NPC) and reporting estimates of formaldehyde exposure as well as the most recent meta-analyses [53] . Results of the cohort studies reviewed by Duhayon reported that mortality from NPC was elevated compared with that of the US general population [54] . However, internal comparison analysis using alternative categorization revealed that none of the relative risk for NPC was statistically significantly increased in any category of exposure.…”

Section: Health Effect To Humanmentioning

confidence: 99%

“…For cancer effect studies, formaldehyde was long considered as a potential human carcinogen (Group 2A chemical) based on experimental animal studies and limited evidence of human carcinogenicity. However, formaldehyde was reclassified as a human carcinogen (Group 1) by the International Agency for Research on Cancer (IARC) in June 2004 based on "sufficient epidemiological evidence that formaldehyde causes nasopharyngeal cancer in humans" [53,54] . Further more, there are cohort and case-control studies investigating the association between occupational exposure to formaldehyde and Nasopharyngeal Cancer (NPC) and reporting estimates of formaldehyde exposure as well as the most recent meta-analyses [53] .…”

Section: Health Effect To Humanmentioning

confidence: 99%

The Health Risk of Formaldehyde to Human Beings

Norliana¹,

Abdulamir²,

Bakar³

et al. 2009

American J. of Pharmacology and Toxicology

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Problem statement: Formaldehyde was classified as a potential human carcinogen, identified by the US Environmental Protection Agency and International Agency for Research on Cancer as a Class 2A carcinogen. It also can cause irritation to human. However, formaldehyde present in biological fluids or tissues and environment as a result of natural processes or from man-made sources and can be emitted slowly into the air. Formaldehyde was used in many industries, hospitals and research as a sterilizing and preserving agent. The utmost concern of this study was about the present of formaldehyde in seafood product. Approach: A review was done on the health effect adverse by formaldehyde, formaldehyde toxicity to human, formaldehyde in seafood and methods to control formaldehyde in food and seafood. Google, Pubmed, Science Direct and Scopus were used in preparation of this review. Results: This review clarified that one of the formaldehyde source to human was seafood. Previous study showed that seafood contained high amount of formaldehyde because of natural production by postmortem enzymatic reaction besides the used of formaldehyde as preservative. Based on prior studies, exposure to formaldehyde can cause irritation and genotoxicity effect. For cancer effect studies, formaldehyde was long considered as a potential human carcinogen based on experimental animal studies and limited evidence of human carcinogenicity. Conclusion: Several mefinding of many health effect of formaldehyde, suggests that the investigation of level of formaldehyde in seafthods have been suggested to reduce formaldehyde in food such as cooking and washing. The ood should be done and also the level of formaldehyde natural production.

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“…Several recent studies have shown an increased risk of major fetal malformations in pregnant women who work with organic solvents occupationally (Khattak et al, 1999;Till et al, 2001;Bedino, 2002;Laslo-Baker, 2004, Chevrier et al, 2006; et al, , Garlantezec et al, 2009. While much of the recent research specifically on formaldehyde has dealt with its possible relationship to nasopharyngeal, sinonasal, and oral cancers (Coggon et al, 2003;Arts et al, 2006;Bosetti et al, 2008;Duhayon et al, 2008; National Toxicology Program, 2010), and lymphohematopoietic malignancies Hauptmann et al, 2009), there are several studies, which have focused on its potential reproductive effects. Formaldehyde has been indicted as a reproductive hazard to those who work with it at high concentration, such as wood industry workers, cosmetologists, and embalmers (John et al, 1994;Taskinen et al, 1999;Bedino, 2002).…”

mentioning

confidence: 98%

Pregnant students in the gross anatomy laboratory: Policies and practices at chiropractic colleges

Duray

Mekow

2011

Anatomical Sciences Ed

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Chiropractic and medical colleges have experienced a significant increase in the number of female applicants in recent years, a percentage of whom are pregnant or become pregnant following admission. It is therefore important to ask the question: How do institutions that educate future health care providers address the issue of pregnancy and the gross anatomy laboratory? A survey instrument was developed and pretested. IRB approval was obtained. The administrators charged with overseeing the policies and practices for the gross anatomy laboratory at each of the 16 chiropractic colleges in the USA were identified and contacted. An email containing a link to the Web based survey was sent to each, using SurveyMonkey. The survey response rate was 100%. A majority of colleges (69%) have a written policy regarding pregnancy and the gross laboratory. Of these, 36% allow pregnant students to take the laboratory if a waiver is signed, 18% do not allow them to take the laboratory, 18% allow them to take it without a waiver, and 27% have other policies. In cases where students do not take the gross laboratory while pregnant, 64% of colleges require them to take the laboratory after completion of their pregnancy, 27% require them to complete an alternative (dry) laboratory, and 9% have other policies. Considerable diversity exists in the way colleges address this issue. It is at present unknown whether pregnant students or their fetuses are at any risk from laboratory chemicals. Risk assessment research is needed before consistent policies can be developed.

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Carcinogenic potential of formaldehyde in occupational settings: a critical assessment and possible impact on occupational exposure levels

Abstract: Current occupational exposure levels to formaldehyde, set to protect against local irritation, should not be adapted.

Cited by 39 publications

References 32 publications

Development of French Indoor Air Quality Guidelines

Development of French Indoor Air Quality Guidelines

The Health Risk of Formaldehyde to Human Beings

Pregnant students in the gross anatomy laboratory: Policies and practices at chiropractic colleges

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