Carcinogenicity of fibers and films: A theory

Archer, Victor E.; Dixon, Willard C.

doi:10.1016/0306-9877(79)90008-2

Cited by 31 publications

(11 citation statements)

References 20 publications

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“…However, the molecular mechanism by which asbestos may augment the release of oxygen metabolites from phagocytic cells is unclear. One hypothesis is that oxidant release occurs nonspecifically during "frustrated" phagocytosis by alveolar macrophages and polymorphonuclear leukocytes that are unable to ingest long asbestos fibers completely (33). However, our findings do not support this hypothesis, because the time-dependent pattern (sigmoid type) and increase of ability to induce CL were similar for each sample except wollastonite (Figures 1,2).…”

Section: Discussioncontrasting

confidence: 57%

Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.

Ohyama

Otake

Morinaga

2001

Environ Health Perspect

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Fiber size is an important factor in the tumorigenicity of various mineral fibers and asbestos fibers in animal experiments. We examined the time course of the ability to induce lucigenin-dependent chemiluminescence (CL) from human monocyte-derived macrophages exposed to Japan Fibrous Material standard reference samples (glass wool, rock wool, micro glass fiber, two types of refractory ceramic fiber, refractory mullite fiber, potassium titanium whisker, silicon carbide whisker, titanium oxide whisker, and wollastonite). We determined how fiber length or width might modify the response of cells. We found that the patterns of time-dependent increase of CL (sigmoid type) were similar for each sample except wollastonite. We observed a strong correlation between geometric-mean length and ability to induce CL in seven samples > 6 microm in length over the time course (largest r(2) = 0.9760). Although we also observed a close positive correlation between geometric-mean width and the ability to induce CL in eight samples < 1.8 microm in width at 15 min (r(2) = 0.8760), a sample of 2.4 microm in width had a low ability to induce CL. Moreover, the relationship between width and the rate of increase in ability to induce CL had a negative correlation at 30-60 min (largest r(2) = 0.7473). Our findings suggest that the release of superoxide from macrophages occurs nonspecifically for various types of mineral fibers depending on fiber length.

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Section: Discussioncontrasting

confidence: 57%

Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.

Ohyama

Otake

Morinaga

2001

Environ Health Perspect

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“…A possible explanation for the toxicity of long fibers to alveolar macrophages is associated with frustrated phagocytosis. Frustrated phagocytosis has been proposed when alveolar macrophages are unable to completely engulf fibers; subsequently, oxidants and enzymes leak from the alveolar macrophages and cause cell damage (Archer, 1979). The mechanism of impaired cytoskeletal function due to fTiO 2 is still not elucidated.…”

Section: Discussionmentioning

confidence: 99%

Differences in the Effects of Fibrous and Particulate Titanium Dioxide on Alveolar Macrophages of Fischer 344 Rats

Watanabe

Okada

Kudo

et al. 2002

Journal of Toxicology and Environmental Health, Part A

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Alveolar macrophages are considered to play a major role in the pathophysiology of lung diseases caused by exposure to various kinds of pathogens and particles. In this study, the cytotoxic effect of different shapes of titanium dioxide (TiO(2)) was evaluated on macrophages using a unique magnetometry method and was compared with conventional methods of lactate dehydrogenase (LDH) release, apoptosis measurement, and morphological observations. Alveolar macrophages obtained from Fischer rats (F344) by bronchoalveolar lavage were incubated in vitro for 18 h with Fe(3)O(4) as a magnetometric indicator and fibrous and particulate forms of TiO(2) as test materials. In the control and particulate exposed group, rapid attenuation of the residual magnetic field, so-called "relaxation," was observed immediately after cessation of the external magnetic field. In comparison, a delay of relaxation was observed in alveolar macrophages exposed to fibrous TiO(2). LDH released into serum-free medium induced by exposure to TiO(2) increased significantly in a concentration-dependent manner in macrophages exposed to fibrous TiO(2), while negligible LDH release was observed in macrophages exposed to particulate TiO(2). The DNA ladder detection method and morphological examination detected no apoptosis in macrophages exposed to 60 micro g/ml of fibrous or particulate TiO(2). Electron microscopic examination revealed vacuolar changes and cell surface damage in macrophages exposed to fibrous TiO(2), but no significant changes in macrophages exposed to particulate TiO(2). The results of magnetometry, LDH release, and electron microscopy suggest that cytotoxicity of TiO(2) depends on the shape of the material.

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“…In iron-catalyzed reactions these metabolites can be converted to hydroxyl radicals. Incomplete internalization of long asbestos fibers, so-called frustrated phagocytosis (112), or the specific stimulation of oxidant-producing enzymes such as reduced nicotinamide adenine dinucleotide phosphate oxidase (113) (120). A number of studies evaluating the role of iron and the production of ROS in asbestos toxicity utilize the potent iron chelator desferrioxamine.…”

Section: Introductionmentioning

confidence: 99%

Selected new developments in asbestos immunotoxicity.

Rosenthal¹,

Corsini²,

Simeonova³

1998

Environ Health Perspect

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Research over the past three decades has shown that the mammalian immune system can be altered by the occupational exposure of asbestos. Early clinical studies generally focused on systemic observations of immune alteration such as the number and function of peripheral lymphocytes and monocytes. More recently as the regulatory influence of local immunity in health and disease becomes more defined, immunologic changes occurring in the lung, the primary target organ of asbestos, have been significant areas of investigation. This review will focus on recent studies that examine the influence of asbestos on pulmonary immunity as well as the role of host immune competence in asbestos-related disease. -Environ Health Perspect 106(Suppl 1):159-169 (1998). http://ehpnetl.niehs.nih.gov/docs/1998/Suppl-1/159-169rosenthal/abstract.html

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Carcinogenicity of fibers and films: A theory

Cited by 31 publications

References 20 publications

Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.

Effect of size of man-made and natural mineral fibers on chemiluminescent response in human monocyte-derived macrophages.

Differences in the Effects of Fibrous and Particulate Titanium Dioxide on Alveolar Macrophages of Fischer 344 Rats

Selected new developments in asbestos immunotoxicity.

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