Carcinogenicity study of γ-oryzanol in B6C3F1 mice

Tamagawa, M.; Otaki, Yasuhiro; Takahashi, Tetsuyuki; Otaka, Tadahiko; Kimura, Shota; Miwa, T.

doi:10.1016/0278-6915(92)90136-9

Cited by 14 publications

(11 citation statements)

References 5 publications

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“…In 1992, Tamagawa et al demonstrated in vivo non-toxicity and noncancerogenicity of g-oryzanol in rats and mice. In these studies, groups of 50 males and 50 females were fed a diet containing 0 (control), 200, 600 or 2000 mg goryzanol/kg body weight/day for 78 weeks (mice) or 2 years (rats) and no significant treatment-related changes were observed in the general condition, body weight, food consumption, mortality, organ weight or haematology nor in tumour incidence (Tamagawa et al, 1992 a;1992b). Moreover, a more recent study of Yasukawa et al (1998) demonstrated that rice bran oil active components (sitosterol ferulate, 24-methylcholesterol ferulate, cycloartenol ferulate and 24-methylenecycloartanol ferulate) markedly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA) induced inflammation in mice.…”

Section: Toxicological Studies On Rice Bran Oil Main Componentsmentioning

confidence: 98%

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Cicero

Gaddi

2001

Phytotherapy Research

241

119

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Diet is the first (and sometimes the only) therapeutic approach to hyperlipoproteinaemias. Rice bran oil and its main components (unsaturated fatty acids, triterpene alcohols, phytosterols, tocotrienols, alpha-tocopherol) have demonstrated an ability to improve the plasma lipid pattern of rodents, rabbits, non-human primates and humans, reducing total plasma cholesterol and triglyceride concentration and increasing the high density lipoprotein cholesterol level. Other potential properties of rice bran oil and gamma-oryzanol, studied both in vitro and in animal models, include modulation of pituitary secretion, inhibition of gastric acid secretion, antioxidant action and inhibition of platelet aggregation. This paper reviews the available data on the pharmacology and toxicology of rice bran oil and its main components with particular attention to those studies relating to plasma lipid altering effects.

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Section: Toxicological Studies On Rice Bran Oil Main Componentsmentioning

confidence: 98%

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Cicero

Gaddi

2001

Phytotherapy Research

241

119

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“…114 The findings indicate that, under the experimental conditions described, γ-oryzanol was not carcinogenic in F344 rats and B6C3F1 mice. The inhibitory effect of cycloartenol ferulate, a component of rice, on tumor promotion in two-stage carcinogenesis in mouse skin was studied.…”

Section: A Overview Of Rice and Healthmentioning

confidence: 87%

Organic Rice Bran Oils in Health

Srikaeo

2014

Wheat and Rice in Disease Prevention and Health

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“…In the Ames test, γ-oryzanol did not exhibit any mutagenicity for Salmonella and Escherichia Coli strains under conditions with and without S9 mix [28] . With regard to in vivo studies, Tamagawa et al [29] , [30] reported that oral administration of γ-oryzanol (200–2000 mg/kg body weight/day) for 79 weeks did not promote tumorigenesis in female mice (B6C3F1). Similarly, they confirmed that oral administration of γ–oryzanol for 105 weeks had no negative effects in F344 male rats Tamagawa et al [29] , [30] .…”

Section: Discussionmentioning

confidence: 99%

“…With regard to in vivo studies, Tamagawa et al [29] , [30] reported that oral administration of γ-oryzanol (200–2000 mg/kg body weight/day) for 79 weeks did not promote tumorigenesis in female mice (B6C3F1). Similarly, they confirmed that oral administration of γ–oryzanol for 105 weeks had no negative effects in F344 male rats Tamagawa et al [29] , [30] . The administration periods and doses exceeded those used in the current study for examination of subacute toxicity and these previous studies demonstrated that γ-oryzanol does not show carcinogenicity.…”

Section: Discussionmentioning

confidence: 99%

Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats

Moon¹,

Kim²,

Shimizu

et al. 2017

Toxicology Reports

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A 90-day oral toxicity study of γ-oryzanol, a rice-derived triterpenoid ferulate, was performed by oral gavage administration to male and female Sprague-Dawley rats at doses of 0, 1000, and 2000 mg/kg body weight/day. All rats administered γ-oryzanol survived throughout the study period. Both male and female rats showed no toxicologically significant changes of the general signs, examination findings, body weight, food consumption, functional observational battery results, ophthalmological findings, urinalysis, hematology tests, clinical chemistry tests, organ weights, and necropsy findings. Moreover, there were no histopathological changes related to administration of γ-oryzanol in males and females from the 2000 mg/kg body weight/day group. In conclusion, the no observed adverse effect level (NOAEL) of γ-oryzanol exceeded 2000 mg/kg body weight/day for both male and female rats under the conditions of this study.

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Carcinogenicity study of γ-oryzanol in B6C3F1 mice

Cited by 14 publications

References 5 publications

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Rice Bran Oil and γ‐Oryzanol in the Treatment of Hyperlipoproteinaemias and Other Conditions

Organic Rice Bran Oils in Health

Ninety-day oral toxicity study of rice-derived γ-oryzanol in Sprague-Dawley rats

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