Carcinoid metastasis to extraocular muscles: case reports and review of the literature

Couch, D.A.; O'Halloran, Henry S.; Hainsworth, K.M.; Cowen, David; Baker, Robert S.

doi:10.1076/orbi.19.4.263.2656

Cited by 19 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seventy‐five percent of those treated reported symptomatic improvement in our pooled data which matches the literature for orbital metastases . The growing role of radiotherapy in orbital tumours has been described by Finger and Kim et al ., and this is particularly applicable to EOM metastases where some primary tumours, such as carcinoid, are very radiosensitive . Ophthalmic side effects of radiation include optic neuropathy, corneal scarring and radiation‐induced retinopathy .…”

Section: Discussionsupporting

confidence: 83%

“…The search methodology identified 135 articles. Of these, 43 articles were included, five articles of potential interest could not be accessed and seven articles of potential interest were published in languages other than English with no translation available …”

Section: Literature Reviewmentioning

confidence: 99%

“…68 The growing role of radiotherapy in orbital tumours has been described by Finger 76 and Kim et al, 77 and this is particularly applicable to EOM metastases where some primary tumours, such as carcinoid, are very radiosensitive. 12 Ophthalmic side effects of radiation include optic neuropathy, corneal scarring and radiation-induced retinopathy. 16 Consequently, lowdose palliative radiotherapy of up to 30G is recommended for symptomatic relief.…”

Section: Treatment and Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

Metastasis to the extraocular muscles: a case report, literature review and pooled data analysis

Leung

Wei

Roberts

2018

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

Metastasis to the extraocular muscles (EOM) is rare. The existing literature comprises only of isolated case reports therefore a summative description of these lesions is lacking. This study presents a case of bilateral rectus muscle metastasis from malignant melanoma. Furthermore a literature review and pooled data analysis is undertaken with 43 articles encompassing 77 patients and 101 eyes. Mean age was 53 years, 54% were male, 66% had unilateral involvement and 34% had bilateral involvement. The primary malignancies were melanoma (n = 17, 22%), breast (n = 15, 15%) and carcinoid (n = 11, 14%). A single muscle was involved in 56 eyes (67%) and multiple muscles in 27 eyes (33%). Lateral rectus was most commonly affected (n = 44, 53%). Presenting symptoms included restricted eye movements (n = 48, 62%), proptosis (n = 45, 58%), diplopia (n = 27, 35%) and pain (n = 18, 23%). Scattered case reports have previously made it difficult to characterise this phenomenon thus a pooled data analysis is presented.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Literature Reviewmentioning

confidence: 99%

Section: Treatment and Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Metastasis to the extraocular muscles: a case report, literature review and pooled data analysis

Leung

Wei

Roberts

2018

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“…To our knowledge, there have only been two cases reported in the literature where metastasis has occurred in subcutaneous tissue, as the first clinical manifestation of ileal carcinoid 8,9 . There have also been a few case reports of carcinoid metastases to orbital structures including the choroid, uvea and extraocular muscles, suggesting a relative predilection for carcinoid metastases to these sites 10−13 . Excepting these cases, to our knowledge there has been no previous report of carcinoid tumour metastasizing to skeletal muscle.…”

Section: Discussionmentioning

confidence: 85%

Soft tissue metastasis of carcinoid tumour: a rare manifestation

Quan¹,

Pitman²,

Slavin³

et al. 2004

ANZ Journal of Surgery

View full text Add to dashboard Cite

“…The most common manifestation is a solitary, unilateral tumour, although metastases may rarely be multiple and bilateral. Orbital metastases generally involve the choroid rather than orbital structures (8), the most likely explanation being the high blood flow of the choroids (9). For unknown reasons, the majority of uveal metastases originates in a primary bronchial carcinoid, whereas the majority of extraocular orbital metastases arises from primary tumours of the ileum (6).…”

Section: Discussionmentioning

confidence: 99%

Carcinoid tumour metastatic to the orbit with infiltration to the extraocular orbital muscle

Casar‐Borota¹,

Kloster

Lindal³

2005

APMIS

View full text Add to dashboard Cite

Ninety-three percent of symptomatic patients with small intestinal carcinoid tumours have metastases. The most common sites of metastases are lymph nodes and liver. Orbital metastases have rarely been described and the majority of them involve the choroid rather than extraocular orbital structures. We report a patient who developed proptosis, impairment of vision and reduced ocular motility on the left side, eighteen months after operation for primary intestinal carcinoid tumour with hepatic metastases. CT and MR studies revealed the tumour mass infiltrating the inferior rectus muscle. Biopsy examined by imprint and frozen section showed tumour consistent with metastatic carcinoid. The tumour was removed. HE and staining for cytokeratin, chromogranin, NSE, serotonin, somatostatin and gastrin showed that the tumour tissue corresponded to that of the primary intestinal carcinoid tumour. Intramuscular orbital metastasis from a carcinoid tumour is a rare occurrence. Diagnosis may be difficult, especially where no evidence of primary carcinoid tumour is present. Metastatic orbital carcinoid should be suspected in patients with a clinical history of carcinoid tumour and who develop ocular complaints and mass lesion in the orbit. Complete surgical removal of the tumour is important for optimal restitution of vision and eye movements.

show abstract

Carcinoid metastasis to extraocular muscles: case reports and review of the literature

Cited by 19 publications

References 25 publications

Metastasis to the extraocular muscles: a case report, literature review and pooled data analysis

Metastasis to the extraocular muscles: a case report, literature review and pooled data analysis

Soft tissue metastasis of carcinoid tumour: a rare manifestation

Carcinoid tumour metastatic to the orbit with infiltration to the extraocular orbital muscle

Contact Info

Product

Resources

About